Influence of chitosan coating on the oral bioavailability of gold nanoparticles in rats

Alalaiwe, Ahmed; Carpinone, Paul L.; Alshahrani, Saad; Ansari, Mohammad Javed; Anwer, Mohammed; Alshehri, Sultan; Alshetaili, Abdullah

doi:10.1016/j.jsps.2018.09.011

Cited by 30 publications

(17 citation statements)

References 51 publications

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“…Encapsulated plant extracts acquire excellent biological properties, including cytotoxicity, bioavailability (Alalaiwe et al., 2019; Esmaile et al., 2020), antioxidant (Hertadi, Amari, & Ratnaningsih, 2020), antimicrobial (Sadhukhan et al., 2019), stability and solubility (Muhammad et al., 2020), and anti‐inflammatory and antidiabetic (Vijayakumar et al., 2019) activities with the comparison of extract alone. The above literatures pointed out that the nanotechnology could be an excellent method to improve the functional properties of antioxidants (Esmaile et al., 2020; Madhu et al., 2020), but not always.…”

Section: Functional Properties Of Nanotechnology‐based Antioxidantsmentioning

confidence: 99%

“…The oral bioavailability of chitosan‐coated AuNPs (C‐AuNPs) was about 25‐folds higher than the polyethylene glycol (PEG)‐coated AuNPs (Alalaiwe et al., 2019). Using modified apple polysaccharide to conjugate with AuNPs, the loaded insulin could induce up to 3.36‐folds decrease in blood glucose level of the rats, while the free insulin did not decrease the blood glucose level (Kumari et al., 2020).…”

Section: Functional Properties Of Nanotechnology‐based Antioxidantsmentioning

confidence: 99%

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Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Myint

Xia

et al. 2021

Journal of Food Science

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Botanic bioactive substances have issues with their solubility, stability, and oral bioavailability in the application, which could be improved by nanotechnologies. In another hands, green synthesis of nanoparticles (NPs) with plant extract is also a promising technology for preparation of NPs due to its safety advantage, yet the bioactive botanic substances that could be more than the assistant of the green synthesis of NPs. Based on the above concerns, this review summarized the preparation of botanic NPs with various plant extract, their solubility, stability, and oral bioavailability; specific attention has been paid to the botanic Ag/Au NPs, their capacity of antioxidant, bioavailability, antimicrobial, anti‐inflammatory, and anticancer.

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Section: Functional Properties Of Nanotechnology‐based Antioxidantsmentioning

confidence: 99%

Section: Functional Properties Of Nanotechnology‐based Antioxidantsmentioning

confidence: 99%

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Myint

Xia

et al. 2021

Journal of Food Science

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“…In recent advances, modern age gold nanoparticles are generally administered intravenously instead of orally due to negligible oral absorption and cellular uptake. In a study that evaluated the oral bioavailability of gold nanoparticles coated with chitosan (C-AuNPs) in rats, a natural mucoadhesive polymer, the oral bioavailability of C-AuNPs was found to be 2.46% which is approximately 25 folds higher than polyethylene glycol (PEG) coated gold nanoparticles, reported earlier [20].…”

Section: Discussionmentioning

confidence: 80%

A preliminary report on bioavailability of Ayurvedic Gold Bhasma with four different accompanying media [anupana]

Patil¹,

Wele²,

Patil³

2021

World J. Adv. Res. Rev.

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Background: Gold bhasma [Swarnabhasma] is a ancient Ayurvedic medicine used for rejuvenation and longevity. This is a preliminary attempt to study the bioavailability of this medicine. Objectives: It was aimed to estimate comparative bioavailability of gold bhasma up to five hours after oral dose with four different anupana. Materials and methods: In this in vivo study, 30 healthy human participants were allocated randomly into five groups having six individuals each. Gold bhasma in 30 mg dose was administered orally with four different anupana viz honey [2.5 gm], black pepper-ghee combination [250 mg and 2.5 gm respectively], lactose [250 mg], glucose [250 mg], and plain to participants in each group. Blood samples were collected at 0, 1, 3 and 5 hours after dose. Gold levels in blood were assessed by inductively coupled plasma mass spectrometry [ICP-MS]. Results: Gold levels in all blood samples were in traces. Average Cmax was 0.002333 microgram of gold per liter and Tmax was at 3 hours for honey anupana, showing maximum Cmax among all groups. Conclusions: Preliminary results indicate that bioavailability of gold from gold bhasma may be less than 0.01 % upto first five hours. Gold bhasma mixed with honey resulted in attainment of maximum Cmax. It is evident that accompanying media [anupana] play an important role in absorption of gold bhasma.

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“… 45 , 75 A similar delay in the peak was observed for chitosan-coated gold NPs. 79 The peptide conjugation caused a delayed elimination as witnessed by a larger t 1/2 E in cNP1, cNP2 and cNP4 and an absence of the elimination phase in cNP3. A similar observation was previously reported in which the EGFR-targeted NPs prolonged the plasma and the tumor half-lives and the MRT of lonidamine relative to the non-targeted NPs.…”

Section: Discussionmentioning

confidence: 98%

<p>Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting – Part II: In vitro and in vivo Kinetics Study</p>

Sebak

Gomaa

ElMeshad

et al. 2020

IJN

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Introduction: Nanoparticles (NPs), upon introduction to the biological systems, become wrapped by serum and cellular proteins constituting the protein corona (PC). This PC contributes largely to the NPs' interaction with the biological systems and their subsequent functions. On the one hand, PC can decrease the efficiency of targeting by directing the NPs to the reticuloendothelial system (RES) or by masking the active targeting moieties and decreasing their ability to bind to their target receptors. On the other hand, some components of PC have offered hopes for achieving endogenous targeting. Methods: In this study, we aimed at the investigation of the role of the PC in determining the behavior of cRGDyk peptide-unconjugated and-conjugated NPs (uNPs and cNPs) exhibiting different physicochemical properties and their interaction with melanoma on in vitro and in vivo levels. Mathematical modeling has been utilized to understand the kinetics of the interaction of NPs with the tumor cells and different organs, respectively. Results: Endocytosis and exocytosis were reported to occur simultaneously for the utilized NPs. The balance was largely dependent on the NPs' physicochemical properties and the role of the PC. In addition, distinct proteins present in the PC (illustrated in the results of the PC analysis in part I) have also determined the patterns of the NPs' distribution in different organs and tissues of the vascular system, the RES system and the target tumot tissue. Vitronectin (VN) was found to mediate higher accumulation in integrin receptor-expressing melanoma cells, while complement 3 protein (C3) and clusterin (CLU), as an opsonin and dysopsonin, respectively, regulated the balance between the RES uptake and blood circulation. Discussion: PC, if properly modulated by tuning NPs' physicochemical properties, can serve as a potential venue for optimum utilization of NPs in cancer therapy.

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Influence of chitosan coating on the oral bioavailability of gold nanoparticles in rats

Cited by 30 publications

References 51 publications

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

A preliminary report on bioavailability of Ayurvedic Gold Bhasma with four different accompanying media [anupana]

<p>Distinct Proteins in Protein Corona of Nanoparticles Represent a Promising Venue for Endogenous Targeting – Part II: In vitro and in vivo Kinetics Study</p>

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