Influence of chirality of V(V) Schiff base complexes on DNA, BSA binding and cleavage activity

Khan, Noor‐ul H.; Pandya, Nirali; Maity, Nabin Ch.; Kumar, Manoj; Patel, Rajesh; Kureshy, Rukhsana I.; Abdi, Sayed H. R.; Mishra, Sandhya; Das, Satyabrata; Bajaj, Hari C.

doi:10.1016/j.ejmech.2011.08.020

Cited by 58 publications

(15 citation statements)

References 74 publications

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“…It is also likely that the complexes bound to DNA via intercalation. This is exactly in accordance with observations reported for other chiral Schiff-base complexes [32]. The intrinsic binding constants (K b ) of the complexes 1-6 with DNA were obtained using the equation [33].…”

Section: Absorption Titrationmentioning

confidence: 80%

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Yan

Chang

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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Section: Absorption Titrationmentioning

confidence: 80%

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Yan

Chang

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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“…Many studies reported cleavage/damage of DNA by either vanadium salts [48][49][50][51][52] or complexes [51,[53][54][55][56][57][58][59][60][61][62]. It is known that several transition metals increase the oxidative stress in cells, which for vanadium has been mainly attributed to the generation of hydroxyl radicals by Fenton-like reactions promoted by physiological hydrogen peroxide [54,55].…”

Section: Binding To Dnamentioning

confidence: 99%

Misinterpretations in Evaluating Interactions of Vanadium Complexes with Proteins and Other Biological Targets

Pessoa

Correia

2021

Inorganics

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In aqueous media, VIV- and VV-ions and compounds undergo chemical changes such as hydrolysis, ligand exchange and redox reactions that depend on pH and concentration of the vanadium species, and on the nature of the several components present. In particular, the behaviour of vanadium compounds in biological fluids depends on their environment and on concentration of the many potential ligands present. However, when reporting the biological action of a particular complex, often the possibility of chemical changes occurring has been neglected, and the modifications of the complex added are not taken into account. In this work, we highlight that as soon as most vanadium(IV) and vanadium(V) compounds are dissolved in a biological media, they undergo several types of chemical transformations, and these changes are particularly extensive at the low concentrations normally used in biological experiments. We also emphasize that in case of a biochemical interaction or effect, to determine binding constants or the active species and/or propose mechanisms of action, it is essential to evaluate its speciation in the media where it is acting. This is because the vanadium complex no longer exists in its initial form.

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“…8B). 43 Figure 8C was recorded for each of the complexes upon titration into DNA ([Mn]/[DNA] =0.125). Both of the titration curves demonstrated a hyperchromism with a blueshift, but no significant differences were observed between the two complexes, suggesting the two Schiff base complexes interact with DNA by the naphthalene rings but not the chiral group.…”

Section: Dna Binding Properties By Uv-vis Titration Fluorescence Spementioning

confidence: 99%

Synthesis, Crystal Structure, and Biological Activities of Two Chiral Mononuclear Mn^(III) Complexes

et al. 2014

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Two new chiral mononuclear Mn((III)) complexes, [MnL((R)) Cl (C2 H5 OH)]•C2 H5 OH () and [MnL((S)) (CH3 OH)2 ]Cl•CH3 OH (), {H2 L = (R,R)-or (S,S)-N,N'-bis-(2-hydroxy-1-naphthalidehydene)-cyclohexanediamine} were synthesized and characterized by various physicochemical techniques. Bond valence sum (BVS) calculations and the Jahn-Teller effect indicate that the Mn centers are in a +3 oxidation state. The statuses of the two complexes in the solution were confirmed as a pair of enantiomers by electrospray ionization, mass spectrometry (ESI-MS) spectrum. The binding ability of the complexes with calf thymus CT-DNA was investigated by spectroscopic and viscosity measurements. Both of the complexes could interact with CT-DNA via an intercalative mode with the order of (R-enantiomer) > (S-enantiomer). Under the physiological conditions, the two compounds exhibit efficient DNA cleavage activities without any external agent, which also follows the order of R-enantiomer > S-enantiomer. Interestingly, the concentration-dependent DNA cleavage experiments indicate an optimal concentration of 17.5 μM. In addition, the interaction of the compounds with bovine serum albumin (BSA) was also investigated, which indicated that the complexes could quench the intrinsic fluorescence of BSA by a static quenching mechanism.

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Influence of chirality of V(V) Schiff base complexes on DNA, BSA binding and cleavage activity

Cited by 58 publications

References 74 publications

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Misinterpretations in Evaluating Interactions of Vanadium Complexes with Proteins and Other Biological Targets

Synthesis, Crystal Structure, and Biological Activities of Two Chiral Mononuclear Mn^(III) Complexes

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Influence of chirality of V(V) Schiff base complexes on DNA, BSA binding and cleavage activity

Cited by 58 publications

References 74 publications

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA–binding properties

Misinterpretations in Evaluating Interactions of Vanadium Complexes with Proteins and Other Biological Targets

Synthesis, Crystal Structure, and Biological Activities of Two Chiral Mononuclear Mn(III) Complexes

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Synthesis, Crystal Structure, and Biological Activities of Two Chiral Mononuclear Mn^(III) Complexes