Influence of Chemotherapy for Gestational Trophoblastic Disease on Subsequent Pregnancy Outcome

Treating gestational trophoblastic disease

“…Summarizing the experience from the NETDC with eight other centers, following chemotherapy for GTN, data have been reported concerning the outcome of 2657 later pregnancies [108][109][110][111][112][113][114][115]. These subsequent pregnancies resulted in 2038 (76.7%) live births, 71 (5.3%) premature deliveries, 34 (1.3%) stillbirths and 378 (14.2%) spontaneous abortions.…”

“…Although the frequency of stillbirth seems to be increased, congenital malformations were noted in only 37 infants (1.8%), which is consistent with the general population. Woolas et al [115] noted that there was no difference in either the conception rate or pregnancy outcome between women treated with single-agent MTX and those receiving combination chemotherapy. Also, only 7% of women who wished to become pregnant following chemotherapy for GTN failed to conceive.…”

Management of Gestational Trophoblastic Disease

“…The rate of congenital abnormality was low (1.8%), irrespective of the type of chemotherapy used 63 . The rate of stillbirth was elevated compared with the normal population (18.6 in 1000 births) 64 . However, in another UK study of 241 treated patients who had a pregnancy within 12 months of chemotherapy, there was no significant increased risk of miscarriage, ectopic pregnancy, second molar pregnancy or stillbirth compared to the general UK population.…”

3D color and power Doppler in the diagnosis and assessment of gestational trophoblastic disease

“…Pregnancy outcome after complete remission obtained by intensive chemotherapy was favorable and the treatment showed minimal impact [48]. As for further long-term influence of chemotherapy treatment, menopause was three years earlier than in control women [49].…”