Influence of Chemical and Physical Change of Pollen Microgels on Swelling/De‐Swelling Behavior

Fan, Tengfei; Hwang, Young‐Kyu; Ibrahim, M. S.; Ferracci, Gaia; Cho, Nam‐Joon

doi:10.1002/marc.202000155

Cited by 14 publications

(9 citation statements)

References 40 publications

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“…As shown in Figure 1 , SEC-Fe@Ca was prepared by performing defatting and lysis treatments to effectively remove the cytoplasm and lipid compounds from natural sunflower pollen. The defatting process removes contaminants and attached proteins and lipid compounds, which can cause allergic reactions [ 39 ]. After continuous alkaline lysis and acidolysis treatments, the cytoplasmic materials were removed, as confirmed using attenuated fluorescence intensity measurements for SEC, as shown in Figure 2(a) .…”

Section: Resultsmentioning

confidence: 99%

Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds

et al. 2022

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Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites. In this study, a Janus particle, SEC-Fe@CaT with dual-driven forces, bubble-driving, and magnetic field– (MF–) mediated driving, was prepared via in situ loading of Fe3O4 on a sunflower sporopollenin exine capsule (SEC), and followed by growth of flower-shaped CaCO3 clusters. The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration, and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds. During the movement in blood flow, the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells (RBCs) to release procoagulants, thus promoting activation of platelet and rapid hemostasis. Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models, respectively. In contrast, the similar commercial product Celox™ required approximately 70 s to stop the bleeding in both bleeding modes. This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds. It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.

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Section: Resultsmentioning

confidence: 99%

Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds

et al. 2022

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“…In addition, probiotics always face severe conditions after being ingested in the human gastrointestinal tract (GIT), such as the presence of proteases and unfavorable pH in GIT, which may lead to a substantial decrease in their viability [ 69 , 129 ]. At present, sporopollenin exine capsules (SECs) derived from natural pollen are considered to be a natural microcapsule for the protection of sensitive biomolecules because of their large inner lumen, temperature, pH, ionic strength, and mucosal adhesion resistance [ 130 , 131 ]. However, the presence of many pores on the surface of SEC acts as a double-edged sword, creating access for probiotic encapsulation, but also providing access to digestive juices in GIT, thus reducing the viability of probiotics [ 132 ].…”

Section: Alginate-based Probiotics Deliverymentioning

confidence: 99%

Microencapsulating Alginate-Based Polymers for Probiotics Delivery Systems and Their Application

et al. 2022

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Probiotics exhibit many health benefits and a great potential for broad applications in pharmaceutical fields, such as prevention and treatment of gastrointestinal tract diseases (irritable bowel syndrome), prevention and therapy of allergies, certain anticancer effects, and immunomodulation. However, their applications are limited by the low viability and metabolic activity of the probiotics during processing, storage, and delivery in the digestive tract. To overcome the mentioned limitations, probiotic delivery systems have attracted much attention. This review focuses on alginate as a preferred polymer and presents recent advances in alginate-based polymers for probiotic delivery systems. We highlight several alginate-based delivery systems containing various types of probiotics and the physical and chemical modifications with chitosan, cellulose, starch, protein, fish gel, and many other materials to enhance their performance, of which the viability and protective mechanisms are discussed. Withal, various challenges in alginate-based polymers for probiotics delivery systems are traced out, and future directions, specifically on the use of nanomaterials as well as prebiotics, are delineated to further facilitate subsequent researchers in selecting more favorable materials and technology for probiotic delivery.

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“…There are many applications for microgels in different areas, such as optics, coating, medicine, agriculture, actuators, etc. [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. Most of the reports dedicated to microgels prepared via the self-assembly mechanism observed in precipitation polymerization used poly( N -isopropylacrylamide) (PNIPAM) as a main component [ 6 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Behavior of PNIPAM Microgels in Different Organic Solvents

Komarova

Kozhunova

2022

Molecules

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In this research, we studied, in detail, the behavior of common PNIPAM microgels, obtained through surfactant-free precipitation polymerization, in a number of organic solvents. We showed that many of the selected solvents serve as good solvents for the PNIPAM microgels and that the size and architecture of the microgels depend on the solvent chosen. Expanding the range of solvents used for PNIPAM microgel incubation greatly enhances the possible routes for microparticle functionalization and modification, as well as the encapsulation of water-insoluble species. In this demonstration, we successfully encapsulated water-insoluble Sudan III dye in PNIPAM microgels and prepared the aqueous dispersions of such composite-colored microparticles.

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Influence of Chemical and Physical Change of Pollen Microgels on Swelling/De‐Swelling Behavior

Cited by 14 publications

References 40 publications

Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds

Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds

Microencapsulating Alginate-Based Polymers for Probiotics Delivery Systems and Their Application

Behavior of PNIPAM Microgels in Different Organic Solvents

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