Influence of Charge Density and Distribution on the Internal Structure of Electrostatically Self-assembled Polyelectrolyte Films

Koetse, Marc M.; Laschewsky, André; Jonas, Alain M.; Wagenknecht, W.

doi:10.1021/la011280e

Cited by 22 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CHI‐CS2.6 multilayers had the lowest mass adsorption possibly due to the very high charge density of CS2.6, which requires less CS to compensate the charges of CHI. Koetse et al have also shown that the CS with higher charge density produce thinner layers during multilayer assembly . The multilayer growth of blend systems as studied by QCM‐D had also shown exponential growth like CHI‐HEP system (Fig.…”

Section: Resultsmentioning

confidence: 88%

Multilayer films by blending heparin with semisynthetic cellulose sulfates: Physico-chemical characterization and cell responses

Aggarwal

Groth

2014

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Here, we report fabrication of polyelectrolyte multilayers by blending a natural glycosaminoglycan (heparin) with semisynthetic cellulose sulfates as polyanions paired with polycation chitosan. Two types of polyanionic blends were prepared by mixing heparin with either cellulose sulfates (CS) of high (CS2.6) or intermediate (CS1.6) sulfation degree in equal mass ratios. Multilayer growth was monitored by surface plasmon resonance (SPR) and quartz crystal micro balance with dissipation monitoring (QCM-D) where as surface wettability was measured by water contact angle measurements (WCA). Both SPR and QCM-D showed differences in biomolecular mass adsorption and dissipation values for different multilayers and also helped in estimating the hydration levels of layers. WCA indicated arrangement of polyanion and polycation layers within the multilayer systems, weather distinct layers, or more intermingled multilayers were established. Overall physico-chemical characterization data suggested a dominating incorporation of heparin over CS in blend multilayer systems. Biological interactions of these blend multilayers investigated with C2C12 cells also indicated a leading contribution of heparin in the blend systems. This current study suggested that heparin was preferentially incorporated over CS that are highly sulfated and points towards the dominance of carboxylic groups over sulfate groups in interacting with amino groups of chitosan.

show abstract

Section: Resultsmentioning

confidence: 88%

Multilayer films by blending heparin with semisynthetic cellulose sulfates: Physico-chemical characterization and cell responses

Aggarwal

Groth

2014

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

show abstract

“…The cationic polyamino acids (PLO, PLA) possess higher charge densities in comparison to the polysaccharide, DEAD-D [48]. This higher charge density drives a stronger electrostatic interaction with heparin and would more effectively neutralize the surface anionic charges of heparin [49][50][51][52]. Therefore, heparin condensation is expected to be more efficient with the cationic polyamino acids compared to the polysaccharide (Fig.…”

Section: Discussionmentioning

confidence: 94%

In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template

Abbah

Liu

Lam

et al. 2012

Journal of Controlled Release

View full text Add to dashboard Cite

“…In addition to the nature of polyelectrolyte pair used, charge density, rinsing medium, preparation method (dipping, spin-coating, spraying), temperature, pH and ionic strength strongly affect the final system properties. [10][11][12][13][14][15][16][17] The investigation of such effects relies on the use of very sensitive techniques, being able to detect in situ changes of the order of nanometers or nanograms. For this purpose, in the last decade the use of quartz crystal microbalance with dissipation (QCM-D) has been established for the study of multilayer assembly, structure and responsive properties.…”

Section: Introductionmentioning

confidence: 99%

Short versus long chain polyelectrolyte multilayers: a direct comparison of self-assembly and structural properties

Micciulla

Dodoo

Chevigny

et al. 2014

Phys. Chem. Chem. Phys.

Self Cite

View full text Add to dashboard Cite

a Successful layer-by-layer (LbL) growth of short chain (B30 repeat units per chain) poly(sodium styrene sulfonate) (PSS)-poly(diallyl dimethylammonium chloride) (PDADMAC) multilayers is presented for the first time and compared with the growth of equivalent long chain polyelectrolyte multilayers (PEMs). A detailed study performed by quartz crystal microbalance with dissipation (QCM-D) is carried out and three main processes are identified: (i) initial mass uptake, (ii) adsorption-desorption during layer equilibration and (iii) desorption during rinsing. In contrast to the high stability and strong layer increment of high molecular weight (HMW) PEMs, layer degradation characterizes low molecular weight (LMW) multilayers. In particular, two different instability phenomena are observed: a constant decrease of sensed mass during equilibration after PDADMAC adsorption, and a strong mass loss by salt-free rinsing after PSS adsorption. Yet, an increase of salt concentration leads to much stronger layer growth.First, when the rinsing medium is changed from pure water to 0.1 M NaCl, the mass loss during rinsing is reduced, irrespective of molecular weight. Second, an increase in salt concentration in the LMW PE solutions causes a larger increment during the initial adsorption step, with no effect on the rinsing.Finally, the mechanical properties of the two systems are extracted from the measured frequency and dissipation shifts, as they offer a deeper insight into the multilayer structures depending on chain length and outermost layer. The paper enriches the field of PE assembly by presenting the use of very short PE chains to form multilayers and elucidates the role of preparation conditions to overcome the limitation of layer stability.

show abstract

Influence of Charge Density and Distribution on the Internal Structure of Electrostatically Self-assembled Polyelectrolyte Films

Cited by 22 publications

References 15 publications

Multilayer films by blending heparin with semisynthetic cellulose sulfates: Physico-chemical characterization and cell responses

Multilayer films by blending heparin with semisynthetic cellulose sulfates: Physico-chemical characterization and cell responses

In vivo bioactivity of rhBMP-2 delivered with novel polyelectrolyte complexation shells assembled on an alginate microbead core template

Short versus long chain polyelectrolyte multilayers: a direct comparison of self-assembly and structural properties

Contact Info

Product

Resources

About