Influence of cerebral white matter lesions on the activities of daily living of older patients with mild stroke

Yamashita, Yutaka; Wada, Ikuo; Horiba, Mitsuya; Sahashi, Kento

doi:10.1111/ggi.12580

Cited by 6 publications

(6 citation statements)

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“…Recent studies highlight the importance of white matter injury in the long‐term functional outcome of ischemic stroke . Severe white matter lesions have been suggested as a prognostic factor for poor activities of daily living at discharge in elderly stroke patients . To the best of our knowledge, the present study provides the first evidence that posttreatment of IL‐2mAb (JES6‐1) preserves poststroke white matter integrity and improves functional recovery up to 28 days after stroke.…”

Section: Discussionmentioning

confidence: 58%

“…33,34 Severe white matter lesions have been suggested as a prognostic factor for poor activities of daily living at discharge in elderly stroke patients. 35 To the best of our knowledge, the present study provides the first evidence that posttreatment of IL-2mAb (JES6-1) preserves poststroke white matter integrity and improves functional recovery up to 28 days after stroke. Another major finding of this study is that brain infiltrating injury.…”

Section: Discussionmentioning

confidence: 59%

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IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8⁺ T cells

et al. 2018

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Summary Aims Demyelination, one of the major pathological changes of white matter injury, is closely related to T‐cell–mediated immune responses. Thus, we investigate the role of an IL‐2 monoclonal antibody (IL‐2mAb, JES6‐1) in combatting demyelination during the late phase of stroke. Methods IL‐2mAb or IgG isotype antibody (0.25 mg/kg) was injected intraperitoneally 2 and 48 hours after middle cerebral artery occlusion (MCAO) surgery. Infarct volume, peripheral immune cell infiltration, microglia activation, and myelin loss were measured by 2,3,5‐triphenyte trazoliumchloride staining, immunofluorescence staining, flow cytometry, and Western blot. Intraperitoneal CD8 neutralizing antibody (15 mg/kg) was injected 1 day before MCAO surgery to determine the role of CD8 + T cells on demyelinating lesions. Results IL‐2mAb treatment reduced brain infarct volume, attenuated demyelination, and improved long‐term sensorimotor functions up to 28 days after dMCAO. Brain infiltration of CD8 + T cells and peripheral activation of CD8 + T cells were both attenuated in IL‐2 mAb‐treated mice. The protection of IL‐2mAb on demyelination was abolished in mice depleted of CD8 + T cell 1 week after stroke. Conclusions IL‐2mAb preserved white matter integrity and improved long‐term sensorimotor functions following cerebral ischemic injury. The activation and brain infiltration of CD8 + T cells are detrimental for demyelination after stroke and may be the major target of IL‐2mAb posttreatment in the protection of white matter integrity after stroke.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 59%

IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8⁺ T cells

et al. 2018

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“…Increasing research has suggested that WMI will seriously influence the prognosis of hypertensive ICH patients (Callisaya et al, 2015). Severe WMI may reflect the vulnerability of the brain to further insults and predicts poor outcome after ICH (Lee et al, 2010; Tveiten et al, 2013; Lambert et al, 2016; Yamashita et al, 2016). In summary, WMI after hypertensive ICH was caused by a variety of pathogenic factors and resulted in a worse long-term prognosis.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Intracerebral Hemorrhage on the Progression of White Matter Hyperintensity

Chen

et al. 2018

Front. Hum. Neurosci.

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Objective: The exact relationship between white matter hyperintensity (WMH) and intracerebral hemorrhage (ICH) after ICH remains unclear. In this retrospective study, we investigated whether patients with ICH had more severe WMH progression.Patients and Methods: A total of 2,951 patients aged ≥40 years with ICH who received brain computed tomography (CT) imaging within 12 h of ICH symptom onset were screened. Ninety patients with two fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) assessments, including 36 patients with Lobar ICH, 40 with basal ganglia region ICH and 14 with ICH at other sites, were included in the final study. We selected 90 age- and gender-matched healthy individuals with two MRI scans as the control group. The WMH volumes at baseline and follow-up were assessed using the FLAIR image by MRICRON and ITK-SNAP software, while the hematoma volumes were calculated based on the CT images using ITK-SNAP software.Results: The annual progression rate of WMH was significantly higher in the ICH group compared with the control group (p < 0.05). Furthermore, WMH progression was associated with the ICH volume. The largest ICH volume (>30 mL) was associated with the highest annual progression rate of WMH (p < 0.05). In contrast, no trend toward an association between ICH location and the annual progression rate of WMH was observed (p > 0.05).Conclusions: Our results showed that ICH patients had more severe WMH progression and that larger ICH volume was related to greater progression of WMH after ICH. These results could provide important prognostic information about patients with ICH.

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“…A study found that severe white matter injury is a prognostic factor for poor activities of daily living at discharge in elderly patients with stroke [39]; and severe leukoaraiosis is also independently associated with the long-term mortality in survivors after ICH [40]. The clinical manifestation of ICH patients is strongly connected with the location and the degree of white matter injury.…”

Section: White Matter Injury After Hypertensive Ichmentioning

confidence: 99%

“…Moreover, poststroke activities of daily living (ADL), Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), and the Modified Telephone Interview for Cognitive Status test could all be used to indirectly determine the degree of white matter injury of hypertensive ICH patients [39, 54, 55]. …”

Section: White Matter Injury After Hypertensive Ichmentioning

confidence: 99%

White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage

Zuo

Pan

Qiang

et al. 2017

BioMed Research International

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Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research. In the face of the profound changes of stroke research perspective, we believe that the combination of the lenticulostriate artery, nerve nuclei of the hypothalamus-thalamus-basal ganglia, and the white matter fibers located within the capsula interna will be beneficial to the research of white matter injury and repair. This paper has classified and analyzed the study of white matter injury and repair after hypertensive ICH and also rethought the shortcomings of the current research. We hope that it could help researchers further explore and study white matter injury and repair after hypertensive ICH.

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Influence of cerebral white matter lesions on the activities of daily living of older patients with mild stroke

Abstract: Severe white matter lesions are a prognostic factor for poor ADL at discharge in older patients with stroke who have mild neurological symptoms. Geriatr Gerontol Int 2016; 16: 942-947.

Cited by 6 publications

References 28 publications

IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8⁺ T cells

IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8⁺ T cells

The Impact of Intracerebral Hemorrhage on the Progression of White Matter Hyperintensity

White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage

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Influence of cerebral white matter lesions on the activities of daily living of older patients with mild stroke

Abstract: Severe white matter lesions are a prognostic factor for poor ADL at discharge in older patients with stroke who have mild neurological symptoms. Geriatr Gerontol Int 2016; 16: 942-947.

Cited by 6 publications

References 28 publications

IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells

IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells

The Impact of Intracerebral Hemorrhage on the Progression of White Matter Hyperintensity

White Matter Injury and Recovery after Hypertensive Intracerebral Hemorrhage

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Product

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IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8⁺ T cells

IL‐2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8⁺ T cells