Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functional outcomes of classical rehabilitation and cognitive remediation in schizophrenia

The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting

“…Genotyping of rs4680 was performed with slight modifications with respect to our previous work (Bosia et al 2007). Briefly, genomic DNA was extracted using EXTRAGEN 8C.…”

Cognitive Training for Impaired Neural Systems in Neuropsychiatric Illness

“…Our field must learn to characterize the relationship between an individual patient's characteristics at baselineFincluding genetic factors, developmental stage, possible neurophysiologic biosignatures, and neurocognitive profileFand their ability to make and retain benefits from neuroplasticity-based cognitive training (Bell et al, 2003;Fiszdon et al, 2005;Bosia et al, 2007). For instance, a small study found that schizophrenia patients with the catechol-O-methyl transferase Met (COMT) allele made greater gains in cognitive flexibility after computerized cognitive training than patients without the Met allele, while Vinogradov et al have preliminary data indicating that polymorphisms in the COMT gene may be associated with cognitive gains after training (Bosia et al, 2007;Panizzutti et al, under review).…”

“…For instance, a small study found that schizophrenia patients with the catechol-O-methyl transferase Met (COMT) allele made greater gains in cognitive flexibility after computerized cognitive training than patients without the Met allele, while Vinogradov et al have preliminary data indicating that polymorphisms in the COMT gene may be associated with cognitive gains after training (Bosia et al, 2007;Panizzutti et al, under review). This group has also found that baseline a band resting-state functional disconnectivity in key cortical regions in schizophrenia predicted the response to cognitive training (Hinckley et al, under review), while Klingberg et al have found that lower activation patterns in DLPFC are associated with greater cognitive improvement after training in ADD patients (personal communication).…”

Cognitive Remediation for Schizophrenia

“…116) Genetic polymorphisms that may mediate some aspects of cognitive function in schizophrenia, such as catechol-o-methyl transferase, have been investigated as potential predictors of outcome with cognitive remediation, though with inconsistent results thus far. 117,118) As research proceeds, therefore, appropriate pairing of patients with the cognitive remediation technique most likely to benefit them will maximize the likelihood of successful functional improvement. Cognitive remediation is a promising approach to improve real-world functioning in patients with schizophrenia.…”