Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with Type 1 diabetes

Lacigová, S; Bartůnĕk, L; Cechurová, D; Víšek, Jan Ámos; Gruberová, J; Krčma, Michal; Jankovec, Z; Rušavý, Zdeněk; Zourek, Michal

doi:10.1016/j.diabres.2008.09.007

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…This finding suggested simultaneous impairment of vagal cardiac control and increased sympathetic vasomotor regulation and was also associated with endothelial dysfunction. This association has not been extensively studied yet, and we found conflicting data (25).…”

Section: Discussionmentioning

confidence: 89%

Adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction

et al. 2015

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Section: Discussionmentioning

confidence: 89%

Adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction

et al. 2015

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“…98,99 Loss of autonomic control is associated with impairment of ventricular function independently from endothelial dysfunction. 100 Accumulation of sorbitol, oxidized lipid, and poly (ADP-ribose) polymerase (PARP) and activation of lipoxygenase in peripheral nerve are observed in a high-fat diet rodent model. 101 FFA causes toxicity in cultured neuronal and Schwann cell lines.…”

Section: Lipotoxicity In Tissuesmentioning

confidence: 99%

Role of Lipotoxicity in Endothelial Dysfunction

Kim¹,

Montagnani²,

Chandrasekran³

et al. 2012

Heart Failure Clinics

107

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SUMMARY Lipotoxicity, caused in large part by overnutrition, directly leads to endothelial dysfunction. Excess lipids in both the circulation and at the tissue level contribute to endothelial dysfunction that underlies much of the pathophysiology of both metabolic disease, including obesity and diabetes and their CV complications. Direct lipotoxic effects on other organs as well as secondary insults from endothelial dysfunction synergize to cause substantial morbidity and mortality. Lifestyle interventions, including reduced calorie intake, diet, and exercise as well as a variety of pharmacologic interventions targeting various mechanisms underlying lipotoxicity in vascular endothelium significantly modify metabolic and CV risk.

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“…A recent report from the Steno Diabetes Center suggested that the combination of decreased heart rate variability and a prolonged QTc interval yielded a greatly increased risk of cardiovascular mortality [51]. In a small study examining the effect of cardiovascular autonomic neuropathy on heart function in type 1 diabetes, Lacigova et al [52] suggested that cardiovascular autonomic neuropathy shows little association with endothelial function but is associated with impaired systolic and diastolic left ventricular function. Encouraging findings from the FinnDiane study also suggest that early autonomic dysfunction maybe reversed by interventions such as slow deep breathing [53].…”

Section: Cardiovascular Link To Other Diabetes Complicationsmentioning

confidence: 97%

When Are Type 1 Diabetic Patients at Risk for Cardiovascular Disease?

Orchard

Costacou

2010

Curr Diab Rep

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This discussion of increased cardiovascular risk in patients with type 1 diabetes reviews recent data concerning glycemia and the role of glycemic control in type 1 diabetes, as well as observations of an association with haptoglobin genotype and coronary artery disease events. This genetic predisposition also leads to oxidative damage and appears to be associated with profound high-density lipoprotein dysfunction. This article also briefly discusses recent data on general cardiovascular risk factors and provides updated comments concerning the association of coronary artery disease with other diabetes complications, especially renal disease.

show abstract

Influence of cardiovascular autonomic neuropathy on atherogenesis and heart function in patients with Type 1 diabetes

Cited by 11 publications

References 28 publications

Adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction

Adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction

Role of Lipotoxicity in Endothelial Dysfunction

When Are Type 1 Diabetic Patients at Risk for Cardiovascular Disease?

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