Influence of cannabis and delta-9-tetrahydrocannabinol on the biochemistry of the male reproductive organs

Chakravarty, Indira; Ghosh, J. J.

doi:10.1016/0006-2952(81)90053-8

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…Hypogonadism was also reported by Harclerode et al [98]. A number of other animal studies correspondingly reported that THC reduces the activities of the enzymes, beta-glucuronidase, alpha-glucosidase, acid phosphatase, and fructose-6-phosphatase in a dose-related manner in the testis, prostate as well as in the epididymis [103]. From these findings, it can be concluded that THC interfere with the normal physiology and functioning of the male reproductive organs.…”

Section: Effect On Reproductive Organssupporting

confidence: 59%

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Plessis

Agarwal

Syriac

2015

J Assist Reprod Genet

121

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Marijuana has the highest consumption rate among all of the illicit drugs used in the USA, and its popularity as both a recreational and medicinal drug is increasing especially among men of reproductive age. Male factor infertility is on the increase, and the exposure to the cannabinoid compounds released by marijuana could be a contributing cause. The endocannabinoid system (ECS) is deeply involved in the complex regulation of male reproduction through the endogenous release of endocannabinoids and binding to cannabinoid receptors. Disturbing the delicate balance of the ECS due to marijuana use can negatively impact reproductive potential. Various in vivo and in vitro studies have reported on the empirical role that marijuana plays in disrupting the hypothalamus-pituitary-gonadal axis, spermatogenesis, and sperm function such as motility, capacitation, and the acrosome reaction. In this review, we highlight the latest evidence regarding the effect of marijuana use on male fertility and also provide a detailed insight into the ECS and its significance in the male reproductive system.

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Section: Effect On Reproductive Organssupporting

confidence: 59%

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Plessis

Agarwal

Syriac

2015

J Assist Reprod Genet

121

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“…The present study indicated that THC exhibited significantly stronger α-glucosidase inhibitory activity than CBD in in vitro assay along with slightly better binding energies with functional residues of the target protein, α-glucosidase. These findings agree with a report on in vivo studies, which proposed that THC may decrease enzyme activities involved in sugar metabolism, including α-glucosidase, β-glucuronidase, acid phosphatase and fructose-6-phosphatase ( Chakravarty and Ghosh, 1981 ). Nevertheless, the investigation of α-glucosidase inhibitory effects of THC and CBD in animal model is still required.…”

Section: Resultssupporting

confidence: 93%

α-Glucosidase inhibitory activity of cannabidiol, tetrahydrocannabinol and standardized cannabinoid extracts from Cannabis sativa

Suttithumsatid

Shah

Bibi

et al. 2022

Current Research in Food Science

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“…Bhang intake also caused significant decline in circulating testosterone level due to decline in testicular 3b HSD enzyme activity, a significant variation in the CB1 and CB2 receptors and FAAH protein levels (Fatty Acid Amide Hydrolase) in testes of mice exposed to bhang [ 94 ]. Finally, repeated subcutaneous administration of cannabis extract and delta-9-tetrahydrocannabinol reduced significantly fructose and citric acid contents of male reproductive organs of prepubertal as well as adult albino rats in a dose-related manner in the testis, prostate as well as in the epididymis [ 95 ].…”

Section: Introductionmentioning

confidence: 99%

Smoke, alcohol and drug addiction and male fertility

Sansone

Dato

Angelis

et al. 2018

Reprod Biol Endocrinol

199

113

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In recent decades, the decline in human fertility has become increasingly more worrying: while therapeutic interventions might help, they are vexing for the couple and often burdened with high failure rates and costs. Prevention is the most successful approach to fertility disorders in males and females alike. We performed a literature review on three of the most common unhealthy habits – tobacco, alcohol and drug addiction – and their reported effects on male fertility. Tobacco smoking is remarkably common in most first-world countries; despite a progressive decline in the US, recent reports suggest a prevalence of more than 30% in subjects of reproductive age – a disturbing perspective, given the well-known ill-effects on reproductive and sexual function as well as general health. Alcohol consumption is often considered socially acceptable, but its negative effects on gonadal function have been consistently reported in the last 30 years. Several studies have reported a variety of negative effects on male fertility following drug abuse – a worrying phenomenon, as illicit drug consumption is on the rise, most notably in younger subjects. While evidence in these regards is still far from solid, mostly as a result of several confounding factors, it is safe to assume that cessation of tobacco smoking, alcohol consumption and recreational drug addiction might represent the best course of action for any couple trying to achieve pregnancy.

show abstract

Influence of cannabis and delta-9-tetrahydrocannabinol on the biochemistry of the male reproductive organs

Cited by 10 publications

References 14 publications

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

Marijuana, phytocannabinoids, the endocannabinoid system, and male fertility

α-Glucosidase inhibitory activity of cannabidiol, tetrahydrocannabinol and standardized cannabinoid extracts from Cannabis sativa

Smoke, alcohol and drug addiction and male fertility

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