Influence of calorie reduction on DNA repair capacity of human peripheral blood mononuclear cells

Matt, Katja; Bürger, Katharina; Gebhard, Daniel; Bergemann, Jörg

doi:10.1016/j.mad.2016.02.008

Cited by 17 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CR facilitates the maintenance of genome integrity by accelerating DNA repair, thus leading promoting cellular survival and longevity [40][41][42]. In this study, we demonstrate that a major consequence of ambient PM exposure was associated with pulmonary and systemic genotoxicity, which was reversed in CR-fed mice.…”

Section: Discussionmentioning

confidence: 59%

“…Although previous studies have shown that CR could modulate the redox status [40], maintain the genome integrity [40][41][42], reduce inflammatory activity, and improve immune function [43,44], the molecular mechanisms underlying CR-triggered alteration in a variety of biological functions have yet to be determined. With the aid of transcriptional profiling and analysis of pathway pertubation, herein we were able to systematically illustrate the molecular regulatory networks that contribute to CRinduced antagonistic effects against PM exposure-induced damage.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Caloric restriction attenuates C57BL/6J mouse lung injury and systemic toxicity induced by real ambient particulate matter exposure

Li¹,

Shen²,

Li³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Caloric restriction (CR) is known to improve health and extend life span in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanisms have yet to be defined. Results: Male C57BL/6J mice were fed with CR diet or ad libitum (AL) and exposed to PM for 4 weeks in a real-ambient PM exposure system located at Shijiazhuang, China, with a daily mean concentration (95.77 μg/m³) of PM 2.5. Compared to AL-fed mice, CR-fed mice attenuated PM-induced pulmonary injury and systemic toxicity characterized by reduction in oxidative stress, DNA damage and inflammation. Analysis of RNA sequencing revealed that several pulmonary pathways involved in production of ROS, cytokine production, and inflammatory cell activation were inactivated, while those mediating antioxidant generation and DNA repair were activated in CR-fed mice upon PM exposure. In addition, transcriptome analysis of murine livers revealed that CR led to induction of xenobiotic metabolism and detoxification pathways, corroborated by increased levels of urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and decreased cytotoxicity measured in an ex vivo assay. Conclusion: These novel results demonstrate, for the first time, that CR in mice confers resistance against pulmonary injuries and systemic toxicity induced by PM exposure. CR led to activation of xenobiotic metabolism and enhanced detoxification of PM-bound chemicals. These findings provide evidence that dietary intervention may afford therapeutic means to reduce the health risk associated with PM exposure. Keywords: Caloric restriction, particulate matter, pulmonary injury, systemic effects, RNA sequencing, xenobiotic metabolism.

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Caloric restriction attenuates C57BL/6J mouse lung injury and systemic toxicity induced by real ambient particulate matter exposure

Li¹,

Shen²,

Li³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Although previous studies have shown that CR modulates the redox status [40], maintains the genome integrity [44][45][46] , reduces in ammatory activity, and improves immune function [47,48], the molecular mechanisms underlying CR-triggered alterations in a variety of biological functions have yet to be determined. With the aid of transcriptional pro ling and analysis of pathway pertubation, we were able to systematically illustrate the molecular regulatory networks that contribute to CR-induced antagonistic effects against PM exposure-induced damage.…”

Section: Discussionmentioning

confidence: 99%

Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

Chen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Caloric restriction (CR) is known to improve health and extend lifespan in human beings. The effects of CR on adverse health outcomes in response to particulate matter (PM) exposure and the underlying mechanisms have yet to be defined.Results: Male C57BL/6J mice were fed with a CR diet or ad libitum (AL) and exposed to PM for 4 weeks in a real-ambient PM exposure system located at Shijiazhuang, China, with a daily mean concentration (95.77 μg/m³) of PM2.5. Compared to AL-fed mice, CR-fed mice showed attenuated PM-induced pulmonary injury and extra-pulmonary toxicity characterized by reduction in oxidative stress, DNA damage and inflammation. RNA sequence analysis revealed that several pulmonary pathways that were involved in production of reactive oxygen species (ROS), cytokine production, and inflammatory cell activation were inactivated, while those mediating antioxidant generation and DNA repair were activated in CR-fed mice upon PM exposure. In addition, transcriptome analysis of murine livers revealed that CR led to induction of xenobiotic metabolism and detoxification pathways, corroborated by increased levels of urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and decreased cytotoxicity measured in an ex vivo assay.Conclusion: These novel results demonstrate, for the first time, that CR in mice confers resistance against pulmonary injuries and extra-pulmonary toxicity induced by PM exposure. CR led to activation of xenobiotic metabolism and enhanced detoxification of PM-bound chemicals. These findings provide evidence that dietary intervention may afford therapeutic means to reduce the health risk associated with PM exposure.

show abstract

“…Studien von Matt et al [2] konnten einen positiven Einfluss einer F. X. Mayr-Therapie auf die DNA-Reparaturkapazität im Menschen zeigen, ebenso einen stimulierenden Einfluss auf die mitochondriale Funktion.…”

Section: Stimulierung Zelleigener Reparaturprozesse Durch Kalorienredunclassified

F. X. Mayr im Wandel der Zeiten

Fegerl¹

2020

EHK

View full text Add to dashboard Cite

ZusammenfassungDer Darm wird in seiner Bedeutung für die Gesamtheit des Organismus als immer wichtiger eingeschätzt. Die F. X. Mayr-Therapie bildet eine effektive ganzheitliche Therapiemethode mit großem Präventionspotenzial, aber auch um bestehende Gesundheitsstörungen effektiv und nachhaltig zu behandeln.Mit den 4 Therapieprinzipien Schonung, Säuberung, Schulung, Substitution ist sie eine hervorragende Basismaßnahme, kann individuell abgewandelt und sehr gut mit anderen Therapiekonzepten kombiniert werden.

show abstract

Influence of calorie reduction on DNA repair capacity of human peripheral blood mononuclear cells

Cited by 17 publications

References 31 publications

Caloric restriction attenuates C57BL/6J mouse lung injury and systemic toxicity induced by real ambient particulate matter exposure

Caloric restriction attenuates C57BL/6J mouse lung injury and systemic toxicity induced by real ambient particulate matter exposure

Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure

F. X. Mayr im Wandel der Zeiten

Contact Info

Product

Resources

About