Influence of Calcium on Choline Measurements by 1H MR Spectroscopy of Thigh Muscles

Teixeira, Pedro Augusto Gondim; Hossu, Gabriela; Kauffmann, F.; Sewonu, A.; Constans, Jean-Marc; Blum, Alain; Felblinger, Jacques

doi:10.1007/s00330-014-3131-z

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…50 The performance of MSK MRS showed promising results for benign-malignant differentiation; however, frequent technical and spectral quality issues limit the spread of this technique. 51,52 SNR and field inhomogeneity are major issues on MSK MRS, and 10 to 13% of tumor spectra acquired for clinical proposes on either 1.5-or 3-T scanners are considered uninterpretable despite the use of specific postprocessing tools. 53 Field inhomogeneity is particularly strong in the extremities (hand and foot), where spectral quality tends to be suboptimal.…”

Section: Proton Spectroscopymentioning

confidence: 99%

“…-Calcification or mineralized bone tissue (increased field inhomogeneity) 52 -Hemorrhage and necrotic tissue (underestimation of the choline peak) -Normal muscle (overestimation of the choline due to the physiologic presence of choline in striated muscle) 13 -Fatty tissue (large fat peak can obscure the choline peaks) Saturation bands can be used to adapt the voxel to tumor morphology (►Fig. 6).…”

Section: Proton Spectroscopymentioning

confidence: 99%

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Advanced Techniques in Musculoskeletal Oncology: Perfusion, Diffusion, and Spectroscopy

Teixeira

Beaumont

Hossu

et al. 2015

Semin Musculoskelet Radiol

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The imaging characterization of musculoskeletal tumors can be challenging, and a significant number of lesions remain indeterminate when conventional imaging protocols are used. In recent years, clinical availability of functional imaging methods has increased. Functional imaging has the potential to improve tumor detection, characterization, and follow-up. The most frequently used functional methods are perfusion imaging, diffusion-weighted imaging (DWI), and MR proton spectroscopy (MRS). Each of these techniques has specific protocol requirements and diagnostic pitfalls that need to be acknowledged to avoid misdiagnoses. Additionally, the application of functional methods in the MSK system has various technical issues that need to be addressed to ensure data quality and comparability. In this article, the application of contrast-enhanced perfusion imaging, DWI, and MRS for the evaluation of bone and soft tissue tumors is discussed, with emphasis on acquisition protocols, technical difficulties, and current clinical indications.

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Section: Proton Spectroscopymentioning

confidence: 99%

Section: Proton Spectroscopymentioning

confidence: 99%

Advanced Techniques in Musculoskeletal Oncology: Perfusion, Diffusion, and Spectroscopy

Teixeira

Beaumont

Hossu

et al. 2015

Semin Musculoskelet Radiol

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“…Bone marrow fat quantification on MRI can be achieved by two means: MR single-voxel proton spectroscopy and chemical shift encoding-based water-fat imaging (WFI) 9 . Proton spectroscopy is the gold standard for the quantification of marrow fat content, but the technique is complex, time-consuming and measurements can be influenced by various factors such as magnetic field inhomogeneities, the presence of calcium and tissue architecture 10 . Moreover, it is not possible to generate fat fraction maps based on proton spectroscopy 9 .…”

Section: Introductionmentioning

confidence: 99%

Proximal femur fat fraction variation in healthy subjects using chemical shift-encoding based MRI

Teixeira

Cherubin

Badr³

et al. 2019

Sci Rep

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The objective of this study was to describe the normal variation of bone marrow fat content in the proximal femur considering the influence of side, age, sex and body mass index using fat fraction MRI. From September 2012 to July 2016, the MRI of 131 patients (258 hips) considered to have a normal MRI appearance were retrospectively evaluated. Patient records were searched to allow calculation of the body mass index (BMI). Water-fat based chemical shift MRI was available for all patients included. Proton density fat fraction maps were calculated, and measurements were performed in the femoral epiphysis, intertrochanteric region, and greater trochanter. The influence of patient age, sex, hip side and BMI on fat fraction values was assessed. Fat fraction was significantly different in the different locations evaluated (P = 0.0001). Patient sex and age significantly influenced fat fraction values in all regions evaluated (P < 0.02) with the exception of the epiphysis for sex (p = 0.07). In all locations, PDFF values were higher in men compared to women (3.3%, 4.4% and 13.1% higher in the epiphysis, greater trochanter and intertrochanteric region respectively). The intertrochanteric region presented the lowest fat fraction values with the highest variation compared to the greater trochanter and the epiphysis. BMI only influenced fat fraction values in the intertrochanteric region of females over 42 years old (P = 0.014). The interobserver variability of the measurements performed was considered to be excellent (ICC = 0.968). In conclusion, patient sex, age, and measurement location significantly influenced fat fraction values indicating that specific standards of reference are needed depending on these factors.

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Added-value of advanced magnetic resonance imaging to conventional morphologic analysis for the differentiation between benign and malignant non-fatty soft-tissue tumors

et al. 2020

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Influence of Calcium on Choline Measurements by 1H MR Spectroscopy of Thigh Muscles

Abstract: The presence of calcium led to significant underestimation of choline measurements. The influence of calcium is dependent on its concentration and distribution. Quantitative MR spectroscopy of calcified tumours should be interpreted with caution.

Cited by 5 publications

References 28 publications

Advanced Techniques in Musculoskeletal Oncology: Perfusion, Diffusion, and Spectroscopy

Advanced Techniques in Musculoskeletal Oncology: Perfusion, Diffusion, and Spectroscopy

Proximal femur fat fraction variation in healthy subjects using chemical shift-encoding based MRI

Added-value of advanced magnetic resonance imaging to conventional morphologic analysis for the differentiation between benign and malignant non-fatty soft-tissue tumors

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