Influence of caesarean delivery and maternal factors on fat-soluble vitamins in blood from cord and neonates

González-Corbella, M.J; López-Sabater, M. Carmen; Castellote-Bargalló, A.I; Campoy, Cristina; Rivero-Urgell, M.

doi:10.1016/s0378-3782(98)00070-x

Cited by 14 publications

(18 citation statements)

References 49 publications

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“…In addition, as we had also adjusted for the effects of labour we cannot explain why the level of cord plasma vitamin E should be lower in infants of mothers in the manual group. Our finding that labour affected maternal and cord plasma levels of vitamins A, E and C at delivery agrees with the findings of Gonzalez-Corbella et al (1998) and Woods et al (2002) for vitamins E and C. They reported that maternal and cord blood levels of vitamin E and vitamin C were significantly higher and lower respectively in women who have laboured when compared with women who have not.…”

Section: Factors Affecting Dietary Intakes and Blood Levels Of Vitaminssupporting

confidence: 91%

Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery

et al. 2006

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The aim of the present study was to test the hypothesis that maternal intake of antioxidant vitamins is associated with maternal and cord plasma levels at delivery. Women were recruited in early pregnancy in Aberdeen Maternity Hospital and habitual diet during pregnancy was assessed by a food-frequency questionnaire mailed at 34 weeks gestation. Blood samples were taken at recruitment (n 1149) and maternal (n 1149) and cord blood samples (n 747) taken at delivery for analyses of vitamins A, C, E and b-carotene. Maternal plasma levels of vitamin E and b-carotene at delivery were significantly higher than levels in early pregnancy while levels of vitamins A and C were significantly lower. Positive correlations were observed for maternal levels of all the vitamins between early pregnancy and delivery. At delivery, maternal plasma concentrations of vitamins A, E and b-carotene were significantly higher than cord levels, while maternal levels of vitamin C were significantly lower. There were significant correlations between maternal and cord plasma concentrations for b-carotene and vitamin C but not for vitamins A or E. Maternal dietary intakes were positively correlated with maternal plasma levels of vitamins C, E and b-carotene in early pregnancy, with maternal plasma levels of b-carotene and vitamin C at delivery and with cord plasma levels of b-carotene and vitamin C. The results from the present study show that, in this population, maternal diet influences cord plasma levels of b-carotene and vitamin C, but not vitamins A and E.

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Section: Factors Affecting Dietary Intakes and Blood Levels Of Vitaminssupporting

confidence: 91%

Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery

et al. 2006

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“…Additionally, our result indicated that vitamin A levels in our study were not correlated with birth weight, gestational age and also sex in LPI. These results were consistent with previous research [8,29].…”

Section: Discussionsupporting

confidence: 94%

“…Thus, LPI with cesarean deliveries had relative lower UCB vitamin A level. However, Gonzalez-Corbella MJ et al reported that there was no significant difference in vitamin A levels between vaginal and cesarean deliveries [29]. This inconsistent result may be attributable to fewer subjects (35 vaginal and 21 cesarean deliveries) in the study.…”

Section: Discussionmentioning

confidence: 75%

“…That can be explained that vaginal deliveries without anaesthesia were more stressful events than cesarean deliveries, and this stress was associated with an increase in maternal corticosteroids [28]. Finally, corticosteroids increased placental cord concentrations of vitamin A [29]. Thus, LPI with cesarean deliveries had relative lower UCB vitamin A level.…”

Section: Discussionmentioning

confidence: 99%

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Umbilical cord blood vitamin A levels in relation to the outcome of late-preterm infant: A prospective study

E¹,

Chen²,

Chen³

et al. 2019

Preprint

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Background: Low Vitamin A levels of plasma increase the risk of neonates’ morbidity. However, whether umbilical cord blood (UCB) vitamin A levels have an association with the outcomes of late-preterm infants (LPI) is not well established. This study aimed to determine umbilical cord blood vitamin A levels and their correlation with outcomes of late-preterm infants. Methods: We prospectively studied 208 LPI between January 1, 2014，and June 30, 2015. The specimens of UCB were collected shortly after birth, and vitamin A levels were determined by Enzyme-Linked Immunosorbent Assay. All singleton newborns, with 34+0 weeks to 36+6 weeks’ gestational age, were eligible for study inclusion in the studied time intervals. Exclusion criteria included significant congenital malformations or chromosomal abnormality or congenital metabolic disease, or life-threatening disease. All subjects were implemented to follow up, and jaundice, sepsis, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, death, etc. were recorded. Results: The prevalence of low UCB vitamin A level <0.7 μmol/L was 37.5% in LPI. UCB vitamin A levels of LPI with cesarean section was lower than that with vaginal delivery (0.734 (0.634-0.796) μmol/L VS 0.904 (0.666-1.100) μmol/L P = 0.001). Additionally, binary logistic regression analysis revealed that the cesarean section was an independent risk factor for UCB vitamin A level < 0.7 μmol/L. However, UCB vitamin A levels did not correlate with gestational age, birth weight, and sex. Neonates with hospitalization or oxygen supplementation or RDS group had significantly lower UCB vitamin A levels than their counterparties ( P < 0.05), other than with hyperbilirubinemia or sepsis ( P > 0.05). However, univariate binary logistics regression analysis suggested that UCB vitamin A level < 0.7 μmol/L was not an independent risk factor for hospitalization, oxygen therapy, hyperbilirubinemia, sepsis and RDS. Conclusions: Low umbilical cord blood vitamin A levels are common among late-preterm infants. Delivery with cesarean section is an independent risk factor for low umbilical cord blood vitamin A level. However, there is no evidence that low vitamin A level is associated with morbidity of late-preterm infants, including hyperbilirubinemia, sepsis and respiratory distress syndrome.

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“…Cord blood concentrations of ␤-carotene (41, 42), vitamin C (43, 44), selenium (45,46), and manganese (47,48) have shown positive correlations with maternal values. For vitamin E, positive correlations were observed for lipid-adjusted ␣-tocopherol concentrations and for erythrocyte ␣-tocopherol concentrations in cord and maternal blood (49,50). However, the maternal antioxidant intake does not seem to protect the child from developing pre-type 1 diabetes in early childhood.…”

Section: Discussionmentioning

confidence: 95%

Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child

Uusitalo

Kenward

Virtanen

et al. 2008

The American Journal of Clinical Nutrition

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Influence of caesarean delivery and maternal factors on fat-soluble vitamins in blood from cord and neonates

Cited by 14 publications

References 49 publications

Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery

Maternal intake of antioxidant vitamins in pregnancy in relation to maternal and fetal plasma levels at delivery

Umbilical cord blood vitamin A levels in relation to the outcome of late-preterm infant: A prospective study

Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child

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