Influence of cadmium on oxidative stress and NADH oscillations in mussel mitochondria

Hanana, Houda; Kleinert, Christine; André, C.; Gagné, François

doi:10.1016/j.cbpc.2018.11.005

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…Cadmium is a well-documented mitochondrial toxin, accumulating within these organelles in vertebrate and invertebrate organisms, including bivalves [ 45 , 46 , 47 , 48 ]. This accumulation results in mitochondrial uncoupling, impaired ATP synthesis, and cellular energy imbalance [ 69 , 70 , 71 ]. Cadmium exposure may induce, in fine, mitochondrial swelling and provoke mitochondrial-dependent apoptosis [ 20 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Table S4: Gene Ontology Biological Process enrichment in zebra and quagga mussel gills after cadmium exposure. Table S5: Short Summary of protein functions extracts from online database annotations [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 …”

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confidence: 99%

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Cadmium Highlights Common and Specific Responses of Two Freshwater Sentinel Species, Dreissena polymorpha and Dreissena rostriformis bugensis

Bultelle,

Le Saux,

David

et al. 2024

Proteomes

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Zebra mussel (ZM), Dreissena polymorpha, commonly used as a sentinel species in freshwater biomonitoring, is now in competition for habitat with quagga mussel (QM), Dreissena rostriformis bugensis. This raises the question of the quagga mussel’s use in environmental survey. To better characterise QM response to stress compared with ZM, both species were exposed to cadmium (100 µg·L−1), a classic pollutant, for 7 days under controlled conditions. The gill proteomes were analysed using two-dimensional electrophoresis coupled with mass spectrometry. For ZM, 81 out of 88 proteoforms of variable abundance were identified using mass spectrometry, and for QM, 105 out of 134. Interestingly, the proteomic response amplitude varied drastically, with 5.6% of proteoforms of variable abundance (DAPs) in ZM versus 9.4% in QM. QM also exhibited greater cadmium accumulation. Only 12 common DAPs were observed. Several short proteoforms were detected, suggesting proteolysis. Functional analysis is consistent with the pleiotropic effects of the toxic metal ion cadmium, with alterations in sulphur and glutathione metabolisms, cellular calcium signalling, cytoskeletal dynamics, energy production, chaperone activation, and membrane events with numerous proteins involved in trafficking and endocytosis/exocytosis processes. Beyond common responses, the sister species display distinct reactions, with cellular response to stress being the main category involved in ZM as opposed to calcium and cytoskeleton alterations in QM. Moreover, QM exhibited greater evidence of proteolysis and cell death. Overall, these results suggest that QM has a weaker stress response capacity than ZM.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cadmium Highlights Common and Specific Responses of Two Freshwater Sentinel Species, Dreissena polymorpha and Dreissena rostriformis bugensis

Bultelle,

Le Saux,

David

et al. 2024

Proteomes

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“…This finding may be related to the effect of Cd on the oxidation rate of NADH and its destruction of the tricarboxylic acid cycle. 24 Quercetin was reported to increase the cytosolic NAD þ /NADH redox potential and the oxidation of NADH. 25 When high-dose quercetin and Cd are simultaneously administered to rats, the intensities of taurine and PCr were significantly increased in group DQ2 compared with those in group D (Online Supplementary Table S5).…”

Section: Discussionmentioning

confidence: 99%

Effects of quercetin on cadmium-induced toxicity in rat urine using metabonomics techniques

et al. 2019

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This study aimed to analyse the protective effects of quercetin on the toxicity of cadmium (Cd) using metabonomics techniques. Sixty male Sprague–Dawley rats were randomly divided into six groups ( n = 10): control group (C), low-dose quercetin-treated group (Q1; 10 mg/kg bw/day), high-dose quercetin-treated group (Q2; 50 mg/kg bw/day), Cd-treated group (D; 4.89 mg/kg bw/day), low-dose quercetin plus Cd-treated group (DQ1) and high-dose quercetin plus Cd-treated group (DQ2). The rats continuously received quercetin and Cd via gavage and drinking water for 12 weeks, respectively. The rat urine samples were collected for metabonomics analysis. Finally, 10 metabolites were identified via the metabonomics profiles of the rat urine samples. Compared with the control group, the intensities of taurine, phosphocreatine, l-carnitine and uric acid were significantly decreased ( p < 0.01) and those of LysoPC (18: 2 (9Z, 12Z)), guanidinosuccinic acid, dopamine, 2,5,7,8-tetramethyl-2(2′-carboxyethyl)-6-hydroxychroman and allantoic acid were significantly increased ( p < 0.01) in the Cd-treated group. However, the intensities of the aforementioned metabolites had restorative changes in the high-dose quercetin plus Cd-treated groups unlike those in Cd-treated group ( p < 0.01 or p < 0.05). Results indicated that quercetin exerts protective effects on Cd-induced toxicity by regulating energy and lipid metabolism, enhancing the antioxidant defence system and protecting liver and kidney function and so on.

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“…Most aquatic species display a rise in expression of MTs at the transcriptional and proteic levels when exposed from 30 ng/L to 500 mg/L of Cd and Cu [29,32,34]. For example, freshwater mussels Dreissena r. bugensis show a four-fold increase in MTs when exposed to 50 or 100 µg/L of Cd for seven days [37]. Mytilus spp.…”

Section: Metallothioneinsmentioning

confidence: 99%

“…However, in some species such as clams, ATP production is maintained during Cu (150 µg/L) exposure, probably due to anaerobic metabolism stimulation, in most tissues except hemolymph [67]. Moreover, the oxidation of NADH during electron transport is affected by Cd [37]. In fish, Cd treatment can inhibit Na + /K + -ATPase activity and expression in the major osmoregulatory organs: gills and kidneys [44].…”

Section: Metabolism Reshufflementioning

confidence: 99%

New Insights into Cellular Impacts of Metals in Aquatic Animals

et al. 2020

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Toxic metals remain a current important threat to aquatic ecosystems, despite regulatory efforts to reduce their release. Several toxic metals already appear in the list of priority substances polluting surface waters, while concerns arise from the increasing use of technology-critical metals such as metallic nanoparticles, rare-earth, and platinum group metals. In aquatic environments, various chemical, biological and physical processes determine the impact of metals on the biota. This review provides insights into responses to toxic metals recently reported in freshwater and marine animals. The specific emphasis is on: (i) common cellular and molecular responses; (ii) stress proteins; (iii) redox homeostasis; (iv) cytoskeleton rearrangement; (v) metabolism reshuffle; (vi) free cellular energy and mitochondrial metabolism; and (vi) immunity. These endpoints are promising, notably in multi-biomarker approaches to identify precise cellular toxicity pathways and anticipate the impact of environmental metal pollution.

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Influence of cadmium on oxidative stress and NADH oscillations in mussel mitochondria

Cited by 6 publications

References 37 publications

Cadmium Highlights Common and Specific Responses of Two Freshwater Sentinel Species, Dreissena polymorpha and Dreissena rostriformis bugensis

Cadmium Highlights Common and Specific Responses of Two Freshwater Sentinel Species, Dreissena polymorpha and Dreissena rostriformis bugensis

Effects of quercetin on cadmium-induced toxicity in rat urine using metabonomics techniques

New Insights into Cellular Impacts of Metals in Aquatic Animals

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