Influence of bowel habits on gut-derived toxins in peritoneal dialysis patients

Pereira, Natalia Barros Ferreira; Ramos, Christiane Ishikawa; Andrade, Laila Santos de; Teixeira, Renata Rodrigues; Nakao, Lia S.; Rodrigues, Silvia; Lima, Jordana Dinorá de; Dalboni, Maria Aparecida; Cuppari, Lílian

doi:10.1007/s40620-020-00819-9

Cited by 15 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the overall negative correlation between BSS, as a marker of transit time, and plasma levels of HA and pCS, especially in a more advanced stage of CKD, suggests that it should be explored whether preservation/modulation of transit time could affect circulating levels of the pCS. Similar observations were made in patients on automatized peritoneal dialysis [44] and in in patients with non-dialysis-dependent CKD [45].…”

Section: Discussionsupporting

confidence: 80%

Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease

Gryp

Faust

Biesen

et al. 2021

JPM

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is characterized by the accumulation of uremic toxins which exert deleterious effects on various organ systems. Several of these uremic toxins originate from the bacterial metabolization of aromatic amino acids in the colon. This study assessed whether the gut microbial composition varies among patients in different stages of CKD. Uremic metabolites were quantified by UPLC/fluorescence detection and microbial profiling by 16S rRNA amplicon sequencing. Gut microbial profiles of CKD patients were compared among stages 1–2, stage 3 and stages 4–5. Although a substantial inter-individual difference in abundance of the top 15 genera was observed, no significant difference was observed between groups. Bristol stool scale (BSS) correlated negatively with p-cresyl sulfate and hippuric acid levels, irrespective of the intake of laxatives. Butyricicoccus, a genus with butyrate-generating properties, was decreased in abundance in advanced stages of CKD compared to the earlier stages (p = 0.043). In conclusion, in this cross-sectional study no gradual differences in the gut microbial profile over the different stages of CKD were observed. However, the decrease in the abundance of Butyricicoccus genus with loss of kidney function stresses the need for more in-depth functional exploration of the gut microbiome in CKD patients not on dialysis.

show abstract

Section: Discussionsupporting

confidence: 80%

Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease

Gryp

Faust

Biesen

et al. 2021

JPM

View full text Add to dashboard Cite

show abstract

“…In the same way, it was previously documented that constipation is associated with increased uremic toxins that impacts on intestinal permeability [ 37 ]. However, zonulin levels were not different among peritoneal dialysis patients according to the presence of constipation [ 38 ]. Moreover, after an intervention with prebiotics, zonulin levels did not change despite the reduction of the p-cresyl uremic toxin [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Could serum zonulin be an intestinal permeability marker in diabetes kidney disease?

et al. 2021

View full text Add to dashboard Cite

Zonulin is a protein associated with the tight junction complex opening at the intestinal epithelium, previously linked to obesity, cardiovascular diseases, type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). However, its role in CKD has not been totally elucidated. This study aimed to evaluate zonulin levels in subjects with diabetic kidney disease (DKD). This case-control study included two cases groups: 1) Advanced DKD cases: T2DM patients with estimated glomerular filtration rate (eGFR) <60ml/min/1.73m2; 2) Albuminuric T2DM cases: diabetic patients with urinary albumin excretion (UAE) >30mg/g creatinine, but with eGFR>60ml/min/1.73m2. Two control groups were also included: 1) T2DM controls: patients with T2DM without impaired kidney function; 2) Non-T2DM controls: subjects without T2DM and normal renal function. Serum levels of zonulin were measured by ELISA. Eighty-six individuals were included. Zonulin levels was different among study groups (P = 0.003). T2DM controls presented higher zonulin levels than non-T2DM controls [(131.35 (83.0–170.5) vs. 87.25 (54.7–111.8), P = 0.018] and advanced DKD cases [63.72 (45.03–106.0); P = 0.007]. Zonulin showed a positive correlation with eGFR (r = 0.222; P = 0.040), total cholesterol (r = 0.299; P = 0.034), LDL (r = 0.258; P = 0.021), and negative with albuminuria (r = -0.243; P = 0.024) and body fat (r = -0.271; P = 0.014). In the multivariate logistic regression analyses, zonulin levels were independently associated to renal outcomes [OR 0.99 (0.98–0.99, P = 0.012)] after 5-year inclusion. In conclusion, increased zonulin levels in patients with TD2M without renal disease suggest an impaired intestinal permeability. Moreover, its association with renal outcomes could indicate its use as a disease monitoring marker. However, the mechanisms behind this association should be better understood.

show abstract

“…7,11 More recently, experimental models of CKD and clinical studies in uremic patients have started to link gut dysbiosis, uremic metabolites and motility to constipation. 12–15 Exploration of dysbiosis in feline CKD and its functional changes is in its infancy and represents an important area for future study of disease mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Survey of defecation habits in apparently healthy and chronic kidney disease cats

Jones

Quimby

Summers

et al. 2021

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives Changes in bowel movements (BMs) are an important clinical sign in many diseases, including chronic kidney disease (CKD), and the purpose of this study was to collect information on BMs and fecal scores in both apparently healthy and CKD cats. A secondary aim was to assess owner awareness of BM frequency. Methods Owners were asked to complete an initial online questionnaire about their cat’s health and litter box habits (including predicted BM frequency and fecal scores) and were then asked to clean the box daily for 7 days and report results (observed frequency of BMs and fecal scores) daily. Differences in BM frequency and fecal scores between apparently normal and CKD cats were compared using the Mann–Whitney test, and predicted vs observed data were compared using the Wilcoxon signed rank test. Difference in percentage of cats defecating more or less than once daily were assessed with Fisher’s exact test. Results Survey data from 124 owners of apparently healthy cats and 43 owners of CKD cats who submitted two or more days of daily observations (in addition to the initial questionnaire) were analyzed. Eighty-five percent of apparently healthy cats were observed to defecate one or more times per day and 15% defecated less than once per day. Fifty-eight percent of CKD cats defecated one or more times per day and 42% defecated less than once per day. A significantly higher percentage of CKD cats defecated less than once per day in comparison with apparently healthy cats ( P <0.0001). Observed BM frequency was significantly less in CKD cats compared with healthy cats ( P = 0.02). Observed fecal scores were not significantly different between healthy and CKD cats. Conclusions and relevance The observed BM frequency of cats with CKD was less than apparently healthy cats and represents a clinically important variation from normal.

show abstract

Influence of bowel habits on gut-derived toxins in peritoneal dialysis patients

Cited by 15 publications

References 35 publications

Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease

Gut Microbiome Profiling Uncovers a Lower Abundance of Butyricicoccus in Advanced Stages of Chronic Kidney Disease

Could serum zonulin be an intestinal permeability marker in diabetes kidney disease?

Survey of defecation habits in apparently healthy and chronic kidney disease cats

Contact Info

Product

Resources

About