Influence of Body Composition and Nutrition Parameters in Handgrip Strength: Are There Differences by Sex in Hemodialysis Patients?

Garagarza, Cristina; Flores, Ana Laura; Valente, Ana

doi:10.1177/0884533617725512

Cited by 12 publications

(15 citation statements)

References 40 publications

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“…In hemodialysis patients, overhydration is associated with malnutrition and inflammation, 30 representing a strong predictor of all-cause mortality in this population. 21 We confirmed the significant association between overhydration/extracellular water and hypomagnesemia in hemodialysis patients. 21 We confirmed the significant association between overhydration/extracellular water and hypomagnesemia in hemodialysis patients.…”

Section: Discussionsupporting

confidence: 76%

“…[26][27][28] Handgrip strength is significantly and positively correlated with serum Mg levels in men but negatively correlated with overhydration/extracellular water in both men and women. 21 We confirmed the significant association between overhydration/extracellular water and hypomagnesemia in hemodialysis patients. We also found higher serum CRP levels in hemodialysis patients with hypomagnesemia, which is in agreement with previous observations.…”

Section: Hypomagnesemia In Hemodialysis Patientssupporting

confidence: 76%

“…18 In peritoneal dialysis patients, low serum Mg levels are associated with poorer nutritional status, deteriorating cellular health, increased inflammation, and lower BMI. 12,19 In hemodialysis patients, significant relationships with serum Mg had previously been reported for nutritional status 4,20 and muscle quality, 21,22 but the present study is the first report on the association…”

Section: Discussionmentioning

confidence: 54%

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Relationship of serum magnesium level with body composition and survival in hemodialysis patients

Mizuiri¹,

Nishizawa²,

Yamashita³

et al. 2019

Hemodialysis International

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Introduction: A relationship between serum magnesium (Mg) and body composition parameters has not been reported in hemodialysis (HD) patients. We aimed to clarify whether serum Mg has any association with body composition parameters, or survival in HD patients.Methods: This study included 215 consecutive maintenance HD patients. Laboratory data collection and postdialysis body composition analysis were performed at baseline. The patients were divided based on baseline serum Mg level tertiles (low, medium, and high Mg groups). Kaplan-Meier survival, logistic regression analyses and Cox proportional hazard analyses were conducted.Findings: Among all patients, the median age and dialysis vintage were 73 (65-81) years and 44 (8-96) months, respectively. The serum Mg levels were < 2.3, 2.3-2.5, and > 2.5 mg/dL for the low (n = 67), middle (n = 76), and high (n = 72) Mg groups, respectively. Compared to other groups, low Mg group showed significantly higher age and C-reactive protein levels, but lower serum albumin, normalized protein catabolic rates and frequency of on-line hemodiafiltration. The low, middle, and high Mg groups differed significantly regarding body cell mass (fat-free mass without bone mineral mass and extracellular water) index (BCMI): [5.6 (4.2-6.8), 6.0 (4.8-8.1), 6.7 (4.9-7.5) kg/m 2 , respectively] and overhydration/extracellular water ratio (OH/ECW) [11.7 (4.5-21.9), 4.8 (1.0-14.1), 8.5 (−0.5-15.0) %, respectively] but not regarding body mass index, lean tissue index, fat tissue index. Hypomagnesemia was significantly associated with BCMI [odds ratio (OR) [95% confidence interval (CI)]: 0.85 [0.73-1.00] and OH/ECW (OR [95% CI]: 1.03 [1.01-1.05]), respectively. Kaplan-Meyer 3-year survival rates were 53.6%, 69.7%, and 71.7% in low, middle, and high Mg groups, respectively. However, hypomagnesemia was not significantly associated with 3-year allcause mortality independent of age, serum albumin and C-reactive protein.Discussion: Hypomagnesemia was associated with lower BCMI, more pronounced OH/ECW and poorer Kaplan-Meier 3-year cumulative survival, but was not an independent risk factor for mortality in HD patients.

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Section: Discussionsupporting

confidence: 76%

Section: Hypomagnesemia In Hemodialysis Patientssupporting

confidence: 76%

Section: Discussionmentioning

confidence: 54%

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Relationship of serum magnesium level with body composition and survival in hemodialysis patients

Mizuiri¹,

Nishizawa²,

Yamashita³

et al. 2019

Hemodialysis International

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“…2,4 Moreover, lower HGS has been associated with higher mortality in MHD patients. 3,[5][6][7] As occurs in the general population, 8 a large discrepancy in muscle strength is observed in MHD patients by age and gender. Thus, it is imperative to take into account the specific sex and age differences in muscle strength in studies that investigate associations between HGS and MHD outcomes.…”

Section: Introductionmentioning

confidence: 90%

Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities

et al. 2018

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“…Other studies have also found negative correlations between HGS and age. 10,21,34,35 Another variable associated with malnutrition was MIS, especially among women (OR = 0.382; p = 0.031); and the higher the MIS, the greater the odds ratio for the patient to present malnutrition according to the HGS criteria. Other authors found a significant association between HGS and MIS.…”

Section: Discussionmentioning

confidence: 99%

Handgrip strength as an instrument for assessing the risk of malnutrition and inflammation in hemodialysis patients

Sostisso¹,

Olikszechen²,

Sato³

et al. 2020

Braz. J. Nephrol.

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Indroduction: Establishing which parameters to use for diagnosing malnutrition in hemodialysis patients is a challenge in clinical practice. The handgrip strength (HGS) has stood out as a method of assessing nutritional status. Thus, the aim of this study was to determine the cut-off point for HGS in the assessment of the risk of malnutrition and inflammation in HD patients, and its association with other parameters. Methods: Study carried out in hemodialysis units in the city of Curitiba, Brazil. We obtained the cut-off point of the HGS through the ROC curve, using the malnutrition and inflammation score (MIS) as a reference. We checked the relationship (Odds ratio) between the variables “MIS” and “HGS” with the other study variables using the multivariate analysis (logistic regression). Results: We assessed 238 patients (132 men), between 18 and 87 years of age (median = 59). The HGS cut-off point for diagnosing malnutrition and inflammation according to the reference used was <14.5 kg for women, and <23.5 kg for men. According to the HGS criteria, malnourished patients were older (OR = 0.958), with lower arm circumference (OR = 1.328) and higher scores in the malnutrition and inflammation score (OR = 0.85). Conclusion: HGS was significantly correlated with other nutritional assessment parameters. These results suggest that HGS is a valid screening tool to identify the risk of malnutrition and inflammation in hemodialysis patients.

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Influence of Body Composition and Nutrition Parameters in Handgrip Strength: Are There Differences by Sex in Hemodialysis Patients?

Cited by 12 publications

References 40 publications

Relationship of serum magnesium level with body composition and survival in hemodialysis patients

Relationship of serum magnesium level with body composition and survival in hemodialysis patients

Sex-age-specific handgrip strength and mortality in an incident hemodialysis cohort: The risk explained by nutrition and comorbidities

Handgrip strength as an instrument for assessing the risk of malnutrition and inflammation in hemodialysis patients

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