Influence of BM 12.531 (Prop. INN azimexon) on the lymphocyte transformation and the percentage of active T lymphocytes in vivo and in vitro in man

Boerner, D; Bicker, U.; Ziegler, AG; Stosiek, U; Peters, Helmut

doi:10.1007/bf00200211

Cited by 7 publications

(4 citation statements)

References 6 publications

(7 reference statements)

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“…As shown in Table 6, when NBT reduction was tested in the presence of PMA, the administration of isohematinic acid and BM 12,531 increased the potency by 55% and 18%, compared with that of control. When superoxide generation was measured by the reduction of cytochrome c, PMN from isohematinic acid-treated mice showed significantly ( and a similar optimal dose response of BM 12,531, an immunomodulator, had been reported (3,6). These observations, therefore, exclude a contribution of the drug's antibacterial activity to eradication of those bacteria in mice, but suggest that the primary action of this agent is enhancement of the host resistance to bacterial infections.…”

Section: Effects Of Isohematinic Acid and Bm 12531 On Nbt Reduction supporting

confidence: 61%

“…FK-156, which was isolated from the culture broth of Streptomyces olivaceogriseus, also stimulates nonspecific resistance to bacterial infections (10). BM 12,531, chemically synthesized as an immunomodulator, has been reported to stimulate immune responses including leucocytosis, phagocytosis, and lymphocyte blast formation (4,6,7). This agent also enhances the resistance of cyclophosphamide-treated mice to infections with Candida albicans and P. aeruginosa (5).…”

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confidence: 99%

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Effects of a New Antibiotic, Isohematinic Acid, on the Resistance of Mice to Experimental Infections

Shiraishi

Katayama

Matsuda

et al. 1987

Microbiology and Immunology

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Isohematinic acid, an antibiotic newly isolated from the culture broth of Actinoplanes philippinensis SANK 61681, was assessed for its ability to enhance nonspecific resistance to bacterial infections against Escherichia coli and Pseudomonas aeruginosa in mice. This agent, as well as BM 12,531 (Azimexon), was found to prolong the survival of normal mice infected with E. coli and also of compromised mice infected with either E. coli or P. aeruginosa, whose defense system had been deteriorated by treatment with carboquone, an alkylating agent. Like BM 12,531, isohematinic acid administered to normal mice significantly increased the nitroblue tetrazolium reducing potency of polymorphonuclear leucocytes (PMN), indicating that the microbicidal activity of PMN was enhanced by these agents. In addition, in the compromised mice these agents were able to restore the number of peripheral blood leucocytes, which had been reduced to about 30% of the normal level by carboquone. These results suggest that isohematinic acid, like BM 12,531, enhances nonspecific resistance to these bacterial infections by stimulating the microbicidal activity of PMN and inducing leucocytosis.

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Section: Effects Of Isohematinic Acid and Bm 12531 On Nbt Reduction supporting

confidence: 61%

mentioning

confidence: 99%

Effects of a New Antibiotic, Isohematinic Acid, on the Resistance of Mice to Experimental Infections

Shiraishi

Katayama

Matsuda

et al. 1987

Microbiology and Immunology

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show abstract

“…Only few clinical trials suggesting contradictory results have been performed [4,7,10]. In this randomized double-blind trial we were unable to demonstrate any effect of azimexon on total or active T lymphocyte count and on 3H-thymidine uptake in the lymphocyte blastogenesis response with or without mitogens.…”

Section: Discussionmentioning

confidence: 57%

“…The PHA-stimulated lymphocyte transformation was enhanced after in vitro incubation with azimexon [8]. In a few cancer patients an increase in active E-rosette-forming lymphocytes after treatment with 300 mg azimexon daily for 7 days PO was reported by Boerner et al [4]. In this study the substance was well tolerated following IV and PO administration, and no side-effects were noticed.…”

Section: -(2-cyanaziridinyl-[1]-)-2-(2-carbamoylaziridinyl-mentioning

confidence: 63%