Influence of blood proteins on biomedical analysis. III. Pharmacokinetics and protein binding of gliclazide.

Kobayashi, Kunio; Kimura, Masako; Sakoguchi, Takafumi; Kitani, Y; Hata, Mitsuo; Matsuoka, Akira

doi:10.1248/bpb1978.4.436

Cited by 28 publications

(23 citation statements)

References 12 publications

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“…Absorption of gliclazide is not weIl characterized and amounts to about 80%, but absolute bioavailability is not known (CAMPBELL et al 1980;KOBAYASHI et al 1981). Absorption rate is variable with fast (peak concentration with 4h) and slow absorbers (peak concentration between 4 and 8 h) having been identified.…”

Section: Gliclazide A) Absorptionmentioning

confidence: 99%

“…Dose linearity has been studied only insufficiently. The absorption profile appears to be no different between healthy subjects and NIDDM patients (KOBAYASHI et al 1981(KOBAYASHI et al , 1984SHIBA et al 1986). …”

Section: Gliclazide A) Absorptionmentioning

confidence: 99%

“…The distribution volume assuming complete absorption ranges between 0.19 and 0.26I1kg (KOBAYASHI et al 1981(KOBAYASHI et al ,1984FORElTE et al 1982). Glic\azide is highly bound to albumin by about 95%, with a broad range of 85% -99% (CAMPBELL et al 1980;KOBAYASHI et al 1981KOBAYASHI et al , 1984.…”

Section: B) Distributionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Pharmacology of Sulfonylureas

Groop¹,

Neugebauer²

1996

Oral Antidiabetics

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Section: Gliclazide A) Absorptionmentioning

confidence: 99%

Section: Gliclazide A) Absorptionmentioning

confidence: 99%

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Clinical Pharmacology of Sulfonylureas

Groop¹,

Neugebauer²

1996

Oral Antidiabetics

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“…Reports from the in vivo studies show that, after oral administration, gliclazide is almost completely absorbed (Delrat et al, 2002;Najib et al, 2002). However, due to its low and pH-dependent aqueous solubility (Hong et al, 1998;Özkan et al, 2000;Shewale et al, 2008), Gliclazide absorption rate appears to be slow and variable (Hong et al, 1998;Kobayashi et al, 1981;Davis et al, 2000;Rana, 2010), and therefore, its absorption profile is difficult to decipher.…”

Section: Introductionmentioning

confidence: 99%

“…Impotence occurs in 50% of men with diabetes mellitus. Erectile dysfunction is also associated with some therapeutic agents like antihypertensives, antipsychotics, antidepressants, and drugs for diabetes mellitus (Pallavi et al, 2011;Guay et al, 20003;Martey, 2010).Treatment of Erectile dysfunction involves several natural aphrodisiac potentials. Aphrodisiac is described as any substance that enhances sexual pleasure.Plants like Bhindi, Musk mallow, Peanut, Garlic, Chiense chive, Punarnava, Capsicum, Coconut, Carrot, Ginseng, Ginger, West African Pepper, Gingembre and many other herbs found worldwide has aphrodisiac properties, hence used as sex stimulants for men (Pallavi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Interaction Between Oral Hypoglycemic Drug And Herbal Sex Stimulants: Drug Interactions

Hossain

Akther

Alauddin

et al. 2016

ESJ

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Sexual dysfunction is a common, underappreciated complication of diabetes. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunction (ED). All three forms of male dysfunction can cause significant bother for diabetic patients and can affect their quality of life. Diabetic patients take oral hypoglycemic drug to control their diabetic as well as take herbal sex stimulants to control to increase the libido. The combined use of herbs and drugs has increased the possibility of herb-drug interactions. The study was undertaken to explore the herb-drug interactions. To investigate the herbdrug interactions an in vitro dissolution study in different simulated pH medium were performed. In this study gliclazide containing tablet of 80mg as oral hypoglycemic drug and different herbal sex stimulants available in local market were used. The release mechanism was explored and explained with zero order, first order and Higuchi equations to identify drug interaction. Higher percentage release of gliclazide was found at simulated phosphate buffer of pH 7.4 compared to gastric medium of pH 1.2 and also in presence of herbal sex stimulants. Increased release pattern of gliclazide

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Diabetes Drugs: Present and Emerging

Tilley

Grimsby

Erickson³

et al. 2010

Burger's Medicinal Chemistry and Drug Discovery

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This chapter includes a summary of the mechanism of action, history, and ADME properties compounds selected from four classes of marketed drugs for the treatment of type 2 diabetes. These include the biguanides (metformin), α‐glucosylase inhibitors, sulfonylureas, and glinides. In addition, a discussion of several advanced, emerging classes of drugs together with lead structures is provided. The mechanistic classes of emerging drugs include inhibitors of the sodium glucose cotransporter 2 (SGLT2), glucokinase activators (GKAs), inhibitors of fructose‐1,6‐bisphosphatase (FPase), inhibitors of 11‐β‐sterol dehydrogenase (11‐β‐HSD1), agonists acting on the G‐coupled‐protein receptor GPR119, and mimics of the sirtuin family member SIRT1.

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Influence of blood proteins on biomedical analysis. III. Pharmacokinetics and protein binding of gliclazide.

Cited by 28 publications

References 12 publications

Clinical Pharmacology of Sulfonylureas

Clinical Pharmacology of Sulfonylureas

In Vitro Interaction Between Oral Hypoglycemic Drug And Herbal Sex Stimulants: Drug Interactions

Diabetes Drugs: Present and Emerging

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