Influence of blood flow on intestinal absorption of drugs and nutrients

Wine, D.

doi:10.1016/0163-7258(79)90051-2

Cited by 42 publications

(9 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical bowel manipulation, anesthesia, and restraint decrease the amount of intestinal blood flow and change the distribution of intestinal blood flow (33,34). Intestinal absorption of glucose and other substances are decreased when intestinal blood flow is decreased (9,11,35 (20,44). In the present study, the method was modified to eliminate some of the assumptions in the previous studies.…”

Section: Discussionmentioning

confidence: 99%

The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats.

Uhing¹,

Kammerer²

1995

J. Clin. Invest.

View full text Add to dashboard Cite

The effects of surgical bowel manipulation and anesthesia on intestinal glucose absorption were determined in chronically catheterized rats. Total and passive rates of glucose absorption were measured using 3-0-methyl-glucose (30MG) and L-glucose, metabolically inert analogues of D-glucose. The rates of 30MG absorption immediately postoperative and 4 h later were 86 and 62% less than the absorption rate 6 d postoperative. The absorption rates of 30MG 1 and 2 d postoperative were not different from 6 d postoperative. Absorption of L-glucose was not altered by bowel manipulation and anesthesia. Even after correction for the increased resistance of the unstirred water layer (UWL) after bowel manipulation, the rates of total and active intestinal glucose absorption immediately postoperative were only 11 and 15% of predicted rates of absorption. In chronically catheterized rats, > 75% of luminal 30MG at a concentration of 400 mM was absorbed by active transport. The K. and Vm.. of 30MG active transport corrected for the resistance of the UWL were 11.3 mM and 15.6 !Lmoles/min, respectively. We conclude that measurements of intestinal glucose absorption performed within 24 h of surgical bowel manipulation greatly underestimate active absorption even if corrections are made to account for the increased resistance of the UWL. (J. Clin. Invest. 1995.95:2790-2798

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats.

Uhing¹,

Kammerer²

1995

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Recently Boyd & Parsons (1978) and Parsons & Sanderson (1980) have described a positive linear relation between the net influx of3-O-methyl-D-glucose and cycloleucine in the steady state and the rate of vascular flow through the small intestine of the frog. Indeed, the rate of blood flow through the mammalian intestine is known to influence the absorption of a wide variety of drugs and nutrients from the lumen (see Winne, 1979).…”

Section: Introductionmentioning

confidence: 99%

INFLUENCE OF VASCULAR AND LUMEN FLOW ON SODIUM MOVEMENTS ACROSS ANURAN INTESTINE IN VITRO

Parsons

1982

Exp Physiol

View full text Add to dashboard Cite

There is a positive linear relation between the vascular flow rate and the magnitudes of the unidirectional fluxes of Na in either direction in the steady state across the small intestine of the frog. Both unidirectional Na fluxes increase to the same extent with an increase in vascular flow so there is no apparent effect of flow on net Na movement. Raising the vascular flow rate in individual experiments increases the lumen-blood Na flux proportionately, but reducing the flow from an initially high value reduces the lumen-blood flux only slowly at first then more rapidly. The unidirectional Na fluxes increase linearly as the lumen flow rate is increased. In the colon increasing the vascular flow rate also increases the lumen-blood Na flux but changing the vascular flow rate has little effect on the blood-lumen flux, the net absorption of Na is invariably increased as the vascular flow increases. Using 14C-labelled sucrose as a marker for the extracellular space of the small intestine, it can be shown that the increases in Na flux found with increased vascular flow rates are associated with an increase in this sucrose space. An increase in sucrose space, therefore, seems to enhance the accessibility of the low resistance, paracellular pathways for Na to and from the blood across the epithelium.

show abstract

“…From the model depicted in figure 1, equa tions can be derived describing the relationship between intestinal absorption and the blood flow rate (3,26,27). In this way, it can be tested whether the experimental data fit the theoretical model.…”

Section: Mathematical Modelmentioning

confidence: 99%

“…The quantity E! depends on the blood flow rate and includes the permeability coefficient of the capillary wall (3,20), the second barrier, and approaches unity because of the high perme ability of the capillary wall (29-37).…”

Section: Disappearance Rate From the Intestinal Lumenmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Blood Flow on Intestinal Absorption of Xenobiotics

Winne¹

1980

Pharmacology

View full text Add to dashboard Cite

The dependence of intestinal absorption of xenobiotics on the blood flow rate increases from blood flow independent to blood flow limited absorption as the absorbabilitiy of the substances increases. Since the absorbed substances are mainly drained by the blood flowing through the subepithelial vessels, not only the total flow rate of an intestinal segment but also the intramural blood flow pattern influences the absorption rate. The villous countercurrent exchange represents an additional resistance to the absorption. In rat jejunum a time-dependent decrease of absorption complicates the analysis of experimental data.

show abstract

Influence of blood flow on intestinal absorption of drugs and nutrients

Cited by 42 publications

References 223 publications

The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats.

The effect of surgical bowel manipulation and anesthesia on intestinal glucose absorption in rats.

INFLUENCE OF VASCULAR AND LUMEN FLOW ON SODIUM MOVEMENTS ACROSS ANURAN INTESTINE IN VITRO

Influence of Blood Flow on Intestinal Absorption of Xenobiotics

Contact Info

Product

Resources

About