Influence of Bisoprolol on Blood Glucose, Glucosuria, and Haemoglobin A1 in Noninsulin-Dependent Diabetics

Janka, H. U.; Ziegler, A G; Disselhoff, G; Mehnert, H

doi:10.1097/00005344-198511001-00018

Cited by 24 publications

(15 citation statements)

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“…6,15 Bisoprolol is a ␤ 1 -selective ␤-adrenergic blocker without intrinsic sympathomimetic activity (ISA). Although bisoprolol is a ␤ 1 -selective ␤-blocker without ISA, the results of the previous short-term bisoprolol study 10 and those of the present study suggest that this drug has no adverse effects on glucose metabolism. 16 In the present study, we administered bisoprolol to essential hypertensive patients for 24 weeks, and its hypotensive effects and its effects on glucose metabolism were investigated.…”

Section: Discussioncontrasting

confidence: 45%

“…7,8 In contrast, Sawicki et al reported that selective ␤ 1blockers have no such adverse effects. 10 However, the study duration was only two weeks; such a period is too short to judge the influence of this agent, because antihypertensive therapy is usually longterm. 10 However, the study duration was only two weeks; such a period is too short to judge the influence of this agent, because antihypertensive therapy is usually longterm.…”

Section: Introductionmentioning

confidence: 99%

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THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

Owada

Suda

Hata

et al. 2001

Clinical and Experimental Hypertension

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Bisoprolol, a beta1-selective beta-blocker, was administered to 13 patients with mild to moderate essential hypertension once daily at doses of 5-10 mg for 24 weeks, and its long-term effects on blood pressure and glucose metabolism were investigated. The systolic, diastolic and mean blood pressures were significantly reduced. At the end of the treatment period, the blood glucose level and hemoglobin A1c were not significantly different from those at baseline. In the glucose tolerance test at the end of the treatment period, the blood glucose and plasma insulin levels after a glucose load of 75 g were not significantly different at any time point, and the sums of each were not significantly different from their baseline levels. Based on these results, bisoprolol appears to be a beta1-selective beta-blocker possessing a satisfactory hypotensive effect without any adverse effects on glucose metabolism for long-term use, and is therefore a safe and useful drug for the treatment of essential hypertension.

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Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

Owada

Suda

Hata

et al. 2001

Clinical and Experimental Hypertension

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“…The ClinicalTrials.gov registry yielded a further 157 possible trials, from which no additional trials were identified for inclusion. Several eligible trials were excluded from the analysis because no measure of glycaemic control was reported and data could not be obtained from the authors [23,[27][28][29][30][31][32]. One comparison of two doses of cyclopenthiazide was also excluded [33].…”

Section: Resultsmentioning

confidence: 99%

Quantifying the effects of diuretics and β‐adrenoceptor blockers on glycaemic control in diabetes mellitus – a systematic review and meta‐analysis

Hirst

Farmer

Feakins

et al. 2015

Brit J Clinical Pharma

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AIMSAlthough there are reports that β-adrenoceptor antagonists (beta-blockers) and diuretics can affect glycaemic control in people with diabetes mellitus, there is no clear information on how blood glucose concentrations may change and by how much. We report results from a systematic review to quantify the effects of these antihypertensive drugs on glycaemic control in adults with established diabetes. METHODSWe systematically reviewed the literature to identify randomized controlled trials in which glycaemic control was studied in adults with diabetes taking either beta-blockers or diuretics. We combined data on HbA1c and fasting blood glucose using fixed effects meta-analysis. RESULTSFrom 3864 papers retrieved, we found 10 studies of beta-blockers and 12 studies of diuretics to include in the meta-analysis. One study included both comparisons, totalling 21 included reports. Beta-blockers increased fasting blood glucose concentrations by 0.64 mmol l −1 (95% CI 0.24, 1.03) and diuretics by 0.77 mmol l −1 (95% CI 0.14, 1.39) compared with placebo. Effect sizes were largest in trials of non-selective beta-blockers (1.33, 95% CI 0.72, 1.95) and thiazide diuretics (1.69, 95% CI 0.60, 2.69). Beta-blockers increased HbA1c concentrations by 0.75% (95% CI 0.30, 1.20) and diuretics by 0.24% (95% CI −0.17, 0.65) compared with placebo. There was no significant difference in the number of hypoglycaemic events between beta-blockers and placebo in three trials. CONCLUSIONSRandomized trials suggest that thiazide diuretics and non-selective beta-blockers increase fasting blood glucose and HbA1c concentrations in patients with diabetes by moderate amounts. These data will inform prescribing and monitoring of beta-blockers and diuretics in patients with diabetes.

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“…Now there is a hint that antihypertensive treatment with existing beta blockers may impair glucose tolerance [82,83]. In short-term studies some new beta blockers have not been found to elevate blood glucose (bisoprolol [84], carvedilol [85]), but there is no clear evidence regarding long-term effects.…”

Section: Metabolic Effectsmentioning

confidence: 99%

Newer beta blockers and the treatment of hypertension

McAreavey

Vermeulen

Robertson

1991

Cardiovasc Drug Ther

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Influence of Bisoprolol on Blood Glucose, Glucosuria, and Haemoglobin A1 in Noninsulin-Dependent Diabetics

Cited by 24 publications

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THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

Quantifying the effects of diuretics and β‐adrenoceptor blockers on glycaemic control in diabetes mellitus – a systematic review and meta‐analysis

Newer beta blockers and the treatment of hypertension

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Influence of Bisoprolol on Blood Glucose, Glucosuria, and Haemoglobin A1 in Noninsulin-Dependent Diabetics

Cited by 24 publications

References 0 publications

THE EFFECTS OF BISOPROLOLA SELECTIVE β1-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

THE EFFECTS OF BISOPROLOLA SELECTIVE β1-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

Quantifying the effects of diuretics and β‐adrenoceptor blockers on glycaemic control in diabetes mellitus – a systematic review and meta‐analysis

Newer beta blockers and the treatment of hypertension

Contact Info

Product

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THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION

THE EFFECTS OF BISOPROLOLA SELECTIVE β₁-BLOCKERON GLUCOSE METABOLISM BY LONG-TERM ADMINISTRATION IN ESSENTIAL HYPERTENSION