Influence of birth weight and adult body composition on 17β-estradiol levels in young women

Finstad, Sissi Espetvedt; Emaus, Aina; Potischman, Nancy; Barrett, Emily S.; Furberg, Anne Sofie; Ellison, Peter T.; Jasieńska, Grażyna; Thune, Inger

doi:10.1007/s10552-008-9238-2

Cited by 27 publications

(12 citation statements)

References 57 publications

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“…Indices of foetal development, such as size at birth, have been shown to affect ovarian development [ 13 , 27 ] and life-time ovarian functioning [ 32 ], as well as age at menarche and at menopause [ 1 ]. Furthermore, birth size has been also shown to be positively related with estradiol level in adulthood [ 18 , 32 , 33 ]. Birth weight was also found to be positively related with breast cancer risk in women ([ 2 , 15 , 26 , 52 ]; however see for contradictory results: [ 70 ]).…”

Section: Introductionmentioning

confidence: 99%

Birth size and morphological femininity in adult women

2020

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Background: Women's morphological femininity is perceived to develop under the influence of sex hormones and to serve as a cue of estradiol level, fertility and health in mating context. However, as the studies on direct relationship between femininity and sex steroid levels have reported mixed results, it is still not well understood what factors contribute to inter-women variation in morphological femininity. Epidemiological studies show that indicators of adverse conditions during intrauterine growth and development in utero, such as low birthweight or relative thinness at birth, influence women's physiology ovarian functioning and may be associated with lifetime exposure to estradiol in women. Thus, here we tested if birth parameters are also related with the level of morphological femininity in adult women. Results: One hundred sixty-five healthy women of mean age 28.47 years (SD = 2.39) participated in the study. Facial femininity was estimated based on facial width-to-height ratio (fWHR) and facial shape sexual dimorphism measured in the photos. Body femininity was estimated based on waist-to-hip ratio (WHR) and breast size. Birth weight and birth length were obtained from medical records and ponderal index at birth was calculated. No relationship between birth parameters and facial or body femininity in women of reproductive age was found, also when controlled for adult sex steroid levels and BMI. Conclusions: The results suggest that, although previous research showed that birth parameters predict reproductive development and adult oestradiol level, they do not explain the variance in morphological femininity in women of reproductive age, trait that is thought to be a cue of a woman's estradiol level and fertility in mating context.

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Section: Introductionmentioning

confidence: 99%

Birth size and morphological femininity in adult women

2020

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“…Previously, we observed in the Energy Balance and Breast cancer Aspects (EBBA) study-I that daily cyclic 17β-estradiol was associated with breast cancer risk factors including age at menarche ( Emaus et al , 2008a ) and body composition from birth to adult life ( Furberg et al , 2005 ; Jasienska et al , 2006 ; Emaus et al , 2008b ; Finstad et al , 2009 ; Barrett et al , 2013 ). Furthermore, in a subanalysis, we observed a positive association between daily progesterone concentrations and mammographic density in premenopausal women using a modified Wolfe’s classification ( Furberg et al , 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Cyclic endogenous estrogen and progesterone vary by mammographic density phenotypes in premenopausal women

Iversen

Frydenberg

Furberg

et al. 2016

European Journal of Cancer Prevention

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Estrogen and progesterone are key factors in the development of breast cancer, but it remains unclear whether these hormones are associated with mammographic density phenotypes in premenopausal women. We measured percent mammographic density, nondense area, and absolute mammographic density using computer-assisted breast density readings (Madena) from digitized mammograms taken on a scheduled day of the menstrual cycle (day 7–12) among 202 healthy, premenopausal women (Energy Balance and Breast cancer Aspects Study-I). Daily salivary concentrations of 17β-estradiol and progesterone throughout an entire menstrual cycle and fasting morning serum concentrations of hormones on 3 specific days of the menstrual cycle were assessed. Salivary and serum 17β-estradiol and progesterone were positively associated with percent mammographic density, we observed by 1 SD increase in overall salivary estradiol (β-value equal to 2.07, P=0.044), luteal salivary progesterone (β-value equal to 2.40, P=0.020). Women with above-median percent mammographic density had a 20% higher mean salivary 17β-estradiol level throughout the menstrual cycle. The odds ratio for having above-median percent mammographic density (>28.5%) per 1 SD increase in overall salivary 17β-estradiol was 1.66 (95% confidence interval 1.13–2.45). Women in the top tertile of the overall average daily 17β-estradiol concentrations had an odds ratio of 2.54 (confidence interval 1.05–6.16) of above-median percent mammographic density compared with women in the bottom tertile. Our finding of a relationship between estrogen, progesterone, and percent mammographic density and not with other mammographic density phenotypes in premenopausal women is biologically plausible, but needs to be replicated in larger studies.

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“…BMI (kg/m 2 ) was used to estimate relative weight. Waist circumference (WC, cm) was measured in a horizontal line 2.5 cm above the umbilicus, and hip circumference (HC, cm) was measured at the largest circumference of the hip (Finstad et al , 2009a). WC and HC (measured to the nearest 0.5 cm) were used to calculate Waist-to-Hip Ratio (WHR = WC/HC).…”

Section: Methodsmentioning

confidence: 99%

“…Our previous studies show that 17β-estradiol profiles are associated with age at menarche (Emaus et al ., 2008a), body composition from birth to adult life (Jasienska et al ., 2006a; Finstad et al , 2009a), metabolic profile in adult life (Furberg et al , 2005; Emaus et al ., 2008b) and energy balance throughout the menstrual cycle (Ziomkiewicz et al ., 2008). These associations point to further studies of ovarian hormones in relation to both fecundity and fertility, and reproductive risk factors for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women: the Norwegian EBBA-I study

et al. 2011

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BACKGROUNDOvarian hormones, parity and length of ‘menarche-to-first birth’ time interval are known risk factors for breast cancer, yet the associations between 17β-estradiol, progesterone and these reproductive factors remain unclear.METHODSA total of 204 women (25–35 years) who participated in the Norwegian EBBA-I study collected daily saliva samples for one complete menstrual cycle, and filled in a reproductive history questionnaire. Anthropometry was measured and saliva samples were analyzed for ovarian hormones. Associations between parity, the interval and ovarian hormones, and effects of hormone-related lifestyle factors were studied in linear regression models.RESULTSMean age was 30.7 years, and age of menarche 13.1 years. Parous women had on average 1.9 births, and age at first birth was 24.5 years. No association was observed between parity and ovarian steroids. In nulliparous women, higher waist circumference (≥77.75 cm) and longer oral contraceptive (OC) use (≥3 years) were associated with higher levels of 17β-estradiol. Short (<10 years) versus long (>13.5 years) ‘menarche-to-first birth’ interval was associated with higher overall mean (Ptrend = 0.029), 47% higher maximum peak and 30% higher mid-cycle levels of 17β-estradiol. We observed a 2.6% decrease in overall mean salivary 17β-estradiol with each 1-year increase in the interval.CONCLUSIONSNulliparous women may be more susceptible to lifestyle factors, abdominal overweight and past OC use, influencing metabolic and hormonal profiles and thus breast cancer risk. Short time between ‘menarche-to-first birth’ is linked to higher ovarian hormone levels among regularly cycling women, suggesting that timing of first birth is related to fecundity.

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Influence of birth weight and adult body composition on 17β-estradiol levels in young women

Cited by 27 publications

References 57 publications

Birth size and morphological femininity in adult women

Birth size and morphological femininity in adult women

Cyclic endogenous estrogen and progesterone vary by mammographic density phenotypes in premenopausal women

Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women: the Norwegian EBBA-I study

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