Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis

Abstract

BackgroundBiotin is a water-soluble vitamin acting as a covalently bound coenzyme in regulating energy production. Previous studies have reported that biotin supplementation may influence blood glucose and lipid level in patients with type 2 diabetes mellitus (T2DM).MethodsWe searched Pubmed, Embase, and Cochrane library databases up to 8th August 2022 for studies examining the effects of biotin supplementation in T2DM patients. Pooled effects were measured by weighted mean differences (WMDs) with 95% confidence intervals (CI) using random effects models. Inter-study heterogeneity was assessed and quantified.ResultsA total of five random controlled trials (RCT), involving 445 participants were included. It was suggested that biotin supplementation for 28 to 90 days significantly decreased the level of fasting blood glucose (FBG) (MD: −1.21 mmol/L, 95% CI: −2.73 to 0.31), total cholesterol (TC) (MD: −0.22 mmol/L, 95% CI: −0.25 to −0.19) and triglycerides (TG) (MD: −0.59 mmol/L, 95% CI: −1.21 to 0.03). No significant beneficial effects were observed on insulin (MD: 1.88 pmol/L 95% CI: −13.44 to 17.21). Evidence for the impact of biotin supplementation on the levels of glycated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C) was limited to draw conclusion.ConclusionsBiotin supplementation may decrease FBG, TC and TG levels. However, its influence on insulin is not significant and further studies on the effects of biotin on HbA1c, LDL-C, HDL-C and VLDL-C are expected.

A Retrospective Evaluation of the Laboratory Findings of Dermatology Patients Whose Biotin Levels Were Checked

“…In a meta-analysis examining the effect of biotin usage on glycemic control and lipid profile in patients with type 2 diabetes mellitus conducted in 2022, it was reported that biotin treatment can reduce fasting blood glucose, total cholesterol, and triglyceride levels [ 13 ]. Also, in a study conducted with twins, it was reported that biotin levels were negatively correlated with triglyceride levels [ 14 ].…”

Physiological Associations between Vitamin B Deficiency and Diabetic Kidney Disease

“…The physiological associations between biotin and diabetes have been well-investigated. Numerous in vitro and in vivo studies have demonstrated that biotin could stimulate pancreatic islet glucokinase activity and expression, increase insulin secretion, and induce insulin receptor synthesis in non-diabetic states, whilst considering the significance of biotin as an efficient ameliorator of hyperglycemic status in diabetes [ 117 ]. Although the mechanism of hyperglycemia is different between T1DM and T2DM, biotin plays an important role in glucose homeostasis for both types of diabetes.…”

An Analysis of the Biotin–(Strept)avidin System in Immunoassays: Interference and Mitigation Strategies

“…Pharmacologic uses of biotin have been limited to the treatment of conditions such as [40] biotin-responsive basal ganglia disease (100-300 mg/day), inherited metabolic diseases such as biotinidase (5-10 mg/day) and holocarboxylase synthetase deficiencies (30-40 mg/day), and multiple sclerosis (MS) (up to 300 mg/day) [29]. However, recent studies suggest that biotin supplementation can improve the treatment and management of diseases such as inflammatory bowel disease (IBD) [44], obesity [68], and type II diabetes [69].…”