Influence of biological and environmental factors on hepatic steroid and xenobiotic metabolism in fish: interaction with PCB and β-naphthoflavone

Förlin, Lars; Andersson, Tommy; Koivusaari, Ulla; Hansson, Tiiu

doi:10.1016/0141-1136(84)90069-2

Cited by 72 publications

(20 citation statements)

References 26 publications

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“…The data also imply that males have a higher EROD activity than females. In flounder, but also in other species, Fö rlin et al (1984) reported similar patterns of a higher mono-oxygenase activity and total cytochrome P450 content in mature males compared to mature females. Gonadal sex steroids have been suggested to play an important role in the regulation of gender-dependent differences in cytochrome P450 mediated metabolism of xenobiotics in fish (Fö rlin et al, 1984).…”

Section: Factors Influencing Biomarker Levels In Flounder In the Gulfsupporting

confidence: 52%

“…In flounder, but also in other species, Fö rlin et al (1984) reported similar patterns of a higher mono-oxygenase activity and total cytochrome P450 content in mature males compared to mature females. Gonadal sex steroids have been suggested to play an important role in the regulation of gender-dependent differences in cytochrome P450 mediated metabolism of xenobiotics in fish (Fö rlin et al, 1984). Conclusively, the observed seasonal differences indicating strong season-dependent temporal trends in EROD activity imply that the timing of sample collection is a crucial factor when this biomarker is used in monitoring programmes.…”

Section: Factors Influencing Biomarker Levels In Flounder In the Gulfsupporting

confidence: 52%

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Measurements of biomarker levels in flounder (Platichthys flesus) and blue mussel (Mytilus trossulus) from the Gulf of Gdańsk (southern Baltic)

Kopecka¹,

Lehtonen²,

Baršienė³

et al. 2006

Marine Pollution Bulletin

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In the framework of the EU funded BEEP project a set of biomarkers, gross morphometric indices and tissue concentrations of selected organic pollutants were measured in flounder (Platichthys flesus) and mussels (Mytilus trossulus) collected twice a year (April and October) from three sites in the inner Gulf of Gdań sk between autumn 2001 and spring 2003. In flounder, seasonal differences in most biomarkers were observed, but no correlations with tissue pollutant levels could be found. In mussels, highly variable levels in biomarker responses were seen, but no clear seasonal or spatial trends, directly related to tissue concentrations, could be established. The observed biomarkers distribution the study sites are probably mostly caused by interannual, seasonal and individual variability and, in case of flounder, possibly by exchange of stocks between the sampling sites.

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Section: Factors Influencing Biomarker Levels In Flounder In the Gulfsupporting

confidence: 52%

Section: Factors Influencing Biomarker Levels In Flounder In the Gulfsupporting

confidence: 52%

Measurements of biomarker levels in flounder (Platichthys flesus) and blue mussel (Mytilus trossulus) from the Gulf of Gdańsk (southern Baltic)

Kopecka¹,

Lehtonen²,

Baršienė³

et al. 2006

Marine Pollution Bulletin

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show abstract

“…time required for induction Forlin et al, 1984 . Although the present study was conducted at different times of the year, water temperature differences of only 2.4ЊC were reported between any two species Ž .…”

Section: Discussionmentioning

confidence: 99%

MFO Induction of three Australian fish species

Smith

Gagnon

2000

Environ. Toxicol.

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The use of mixed function oxygenase MFO enzymes as a biomarker of pollution in Port ( ) Phillip Bay was investigated in three indigenous fish species, sand flathead Plathycephalus bassensis , ( ) ( ) bluethroat wrasse Notalabrus tetricus , and sixspine leatherjacket Meuschenia freycineti . Investigation of the relative MFO induction potential was performed by intraperitoneally injecting each experimental X X ( ) fish species with 100 g / kg of 3,3 ,4,4 ,5-pentachlorobiphenyl PCB 126 using corn oil as a carrier. Hepatic induction was fluorimetrically measured by the activity of 7-ethoxyresorufin O-deethylase ( ) EROD activity 10 days post-injection. Of the three species tested, the sand flathead was selected as the most suitable indicator species for its high MFO induction potential and desirable characteristics related to its population biology. Bluethroat wrasse appeared relatively uninducible by PCB 126, while sixspine leatherjacket demonstrated a medium induction potential but was unsuitable as a biomonitoring tool because of its scarcity and distribution limited to reef beds.

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“…In fish, cytochrome P450-dependent monooxygenase activities and conjugating enzymes are modulated by many factors such as seasonal variations, e.g., temperature and photoperiod (Karr et al, 1985;Snegaroff and Bach, 1990;Hanninen et al, 1983), and also food intake, hormonal cycle, and sex differences (Koivusaari, 1983;Koivusaari et al, 1981;Forlin et al, 1984;Andersson, 1990). In mammals as in fish, many factors are capable of modulating the mixedfunction oxygenases.…”

Section: Introductionmentioning

confidence: 97%

Modulation of Drug-Metabolizing Systems by Bacterial Endotoxin in Carp Liver and Immune Organs

Marionnet

Chambras

Taysse

et al. 1998

Ecotoxicology and Environmental Safety

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Influence of biological and environmental factors on hepatic steroid and xenobiotic metabolism in fish: interaction with PCB and β-naphthoflavone

Cited by 72 publications

References 26 publications

Measurements of biomarker levels in flounder (Platichthys flesus) and blue mussel (Mytilus trossulus) from the Gulf of Gdańsk (southern Baltic)

Measurements of biomarker levels in flounder (Platichthys flesus) and blue mussel (Mytilus trossulus) from the Gulf of Gdańsk (southern Baltic)

MFO Induction of three Australian fish species

Modulation of Drug-Metabolizing Systems by Bacterial Endotoxin in Carp Liver and Immune Organs

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