Influence of azelaic acid on acne pathogenesis

Azelaic acid is well suited for the treatment of acne in women, where PIH occurs most often (it is not an obstacle for use during pregnancy), the drug may be combined with systemic and topical therapy, may combined with skin care and decorative cosmetics, has no restrictions when used in active sun, possesses light peeling effect.Material and methods.The study evaluated the effectiveness of the combined method, including systemic isotretinoin and Skinaren®cream 20 %, in patients with moderate acne – group 1A (n = 24) in comparison with isotretinoin monotherapy – group 1B (n = 25). The efficacy of Skinoren®20 % cream was also studied in patients with post-inflammatory hyperpigmentation – the group 2 (n = 37).Research results.The combination of 20 % azelaic acid cream (Skinoren®) with oral isotretinoin (from 4th months of admission) in patients with adult acne allows to influence the formation of post-inflammatory hyperpigmentation, which ultimately leads to a more significant aesthetic result (88 % with the achievement of IGA0) and contributes to an improvement in the quality of life (reduction of APSEA by 87 %) The safety of the 20 % azelaic acid cream (Skinoren®) is assessed as very high, which is confirmed by the absence of adverse events in most patients. The use of 20 % azelaic acid cream (Skinoren®) as a monotherapy for post-inflammatory hyperpigmentation causes a pronounced positive effect in stopping PIH in all patients, while achieving clear skin is noted in 78.4 %.

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Issues of therapy and prevention of post-inflammatory acne pigmentation

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Gryazeva

Bondarenko³

2021

Medicinskij alfavit

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Influence of azelaic acid on acne pathogenesis

Abstract: I In current literature review the physicochemical properties, peculiarities of mode of action and pharmacokinetics of azelaic and influence of azelaic on pathogenetic aspects of acne are characterized.

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Issues of therapy and prevention of post-inflammatory acne pigmentation

Issues of therapy and prevention of post-inflammatory acne pigmentation

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