Influence of Autologous and Homologous Blood Transfusion on Interleukins and Tumor Necrosis Factor-α in Peri-operative Patients with Esophageal Cancer

Xing, Yueli; Wang, Yanchun

doi:10.7314/apjcp.2014.15.18.7831

Cited by 10 publications

(9 citation statements)

References 15 publications

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“…It is known that allogeneic transfusion can aggravate perioperative immunosuppression in cancer patients, and autogenous transfusion seems to be superior to allogeneic transfusion [51, 52], but Harlaar et al did not find any benefit from autologous transfusion compared with allogeneic transfusion after long-term follow-up in colorectal cancer patients [53]. The clinical data for autogenous transfusion in cancer patients are sparse, and the safety of autogenous transfusion is still a big concern in the clinic, as autogenous transfusion has the potential risk to induce iatrogenic metastasis.…”

Section: Discussionmentioning

confidence: 99%

Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

Pang

Liu

2019

World J Surg Onc

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BackgroundPerioperative transfusion can reduce the survival rate in colorectal cancer patients. The effects of transfusion on the short- and long-term prognoses are becoming intriguing.ObjectiveThis systematic review and meta-analysis aimed to define the effects of perioperative transfusion on the short- and long-term prognoses of colorectal cancer surgery.ResultsThirty-six clinical observational studies, with a total of 174,036 patients, were included. Perioperative transfusion decreased overall survival (OS) (hazard ratio (HR), 0.33; 95% confidence interval (CI), 0.24 to 0.41; P < 0.0001) and cancer-specific survival (CSS) (HR, 0.34; 95% CI, 0.21 to 0.47; P < 0.0001), but had no effect on disease-free survival (DFS) (HR, 0.17; 95% CI, − 0.12 to 0.47; P = 0.248). Transfusion could increase postoperative infectious complications (RR, 1.89, 95% CI, 1.56 to 2.28; P < 0.0001), pulmonary complications (RR, 2.01; 95% CI, 1.54 to 2.63; P < 0.0001), cardiac complications (RR, 2.20; 95% CI, 1.75 to 2.76; P < 0.0001), anastomotic complications (RR, 1.51; 95% CI, 1.29 to 1.79; P < 0.0001), reoperation(RR, 2.88; 95% CI, 2.05 to 4.05; P < 0.0001), and general complications (RR, 1.86; 95% CI, 1.66 to 2.07; P < 0.0001).ConclusionPerioperative transfusion causes a dramatically negative effect on long-term prognosis and increases short-term complications after colorectal cancer surgery.

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Section: Discussionmentioning

confidence: 99%

Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

Pang

Liu

2019

World J Surg Onc

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“…Numerous hypotheses had been postulated and the most possible explanation for this phenomenon was blood transfusion-induced immunomodulation. It had been illustrated that perioperative blood transfusion markedly diminished the number of T cell subgroups, nature killer cells and immunoglobins as well as altered cytokine secretions in patients who underwent oncologic surgeries (Guo et al, 2014;Xing et al, 2014). Reasonably, worse outcome could be predicted for blood transfusion during the peri-operative period in either cancer groups or posttransplantation groups according to their pre-existed immunosusceptibility and medication-associated immunosuppression status.…”

Section: Discussionmentioning

confidence: 99%

Clinical Practice of Blood Transfusion in Orthotopic Organ Transplantation: A Single Institution Experience

Tsai

Hsieh²,

Chang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Orthotopic organ transplantation, a treatment option for irreversible organ dysfunction according to organ failure, severe damaged organ or malignancy in situ, was usually accompanied with massive blood loss thus transfusion was required. We aimed to evaluate the adverse impact of blood transfusion on solid organ transplantation. Materials and Methods: From January, 2009 to December, 2014, patients who received orthotopic organ transplantation at Far Eastern Memorial Hospital medical center were enrolled. Clinical data regarding anemia status and red blood cell (RBC) transfusion before, during and after operation, as well as patient outcomes were collected for further univariate analysis. Results: A total of 105 patients who underwent orthotopic transplantation, including liver, kidney and small intestine were registered. The mean hemoglobin (Hb) level upon admission and before operation were 11.6±1.8 g/dL and 11.7±1.7 g/dL, respectively; and the nadir Hb level post operation and the final Hb level before discharge were 8.3±1.6 g/dL and 10.2±1.6 g/dL, respectively. The median units (interquartile range) of RBC transfusion in pre-operative, peri-operative and post-operative periods were 0 (0-0), 2 (0-12), and 2 (0-6) units, respectively. Furthermore, the median (interquartile range) length of hospital stay (LHS) from admission to discharge and from operation to discharge were 28 (17-44) and 24 (16-37) days, respectively. Both peri-operative and post-operative RBC transfusion were associated with longer LHS from admission to discharge and from operation to discharge. Furthermore, it increased the risk of post-operative septicemia. While peri-operative RBC transfusion elevated the risk of acute graft rejection in patients who received orthotopic transplantation. Conclusions: Worse outcome could be anticipated in those who had received massive RBC transfusion in transplantation operation. Hence, peri-operative RBC transfusion should be avoided as much as possible.

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“…Finally, the examination of potential transfusion side effects and events should be the same or similar for autologous and allogeneic transfusions [5][6][7][22][23][24] . Namely, autologous transfusions have no risk of infectious (virus) and immunemediated complications (reduced "biohazard"), but carry a similar risk of bacterial contamination following storage (PAD), circulation volume overload, and misadministration compared with normal allogeneic units.…”

Section: Regardless Of the Implementation Of Different Effective Prevmentioning

confidence: 99%

“…Seldom, due to platelet and WBC activation (in the course blood processing), transfusionrelated acute lung injury (TRALI) can occur -termed also as the "syndrome of salvaged blood". Finally, infection and malignancy in the surgical field are contraindications for performing of the PBR manner 1,[3][4][5][6][22][23][24] .…”

Section: Perioperative Blood Recovery/salvagementioning

confidence: 99%

Autologous transfusions for elective surgery - from existing approaches to upcoming challenges

et al. 2017

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Influence of Autologous and Homologous Blood Transfusion on Interleukins and Tumor Necrosis Factor-α in Peri-operative Patients with Esophageal Cancer

Cited by 10 publications

References 15 publications

Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis

Clinical Practice of Blood Transfusion in Orthotopic Organ Transplantation: A Single Institution Experience

Autologous transfusions for elective surgery - from existing approaches to upcoming challenges

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