Influence of atropine therapy on fenthion-induced pancreatitis

Ela, Yüksel; Fidan, Hüseyin; Şahin, Önder; Kilbas, Aynur; Baş, Orhan; Yılmaz, Yücel; Küçüker, Hüdaverdi; Altuntaş, İrfan

doi:10.1080/15563650701197088

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Pancreatic involvement may range from enzyme elevations to necrotizing pancreatitis that necessitates surgery [3]. Pancreatitis in OP poisoning is generally benign although necrosis, pseudocyst, gut infarction, and uncontrollable hemorrhage have been reported [4].…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatitis in OP poisoning is generally benign although necrosis, pseudocyst, gut infarction, and uncontrollable hemorrhage have been reported [4]. Organophosphates cause excessive pancreatic cholinergic stimulation in the pancreatic acini and also cause ductular hypertension, interstitial edema and enzyme elevation [4–6]. Prevalence of acute pancreatitis has ranged from 0.5% to 62.5% [4, 5] and mortality rates have varied from 5 to 10%.…”

Section: Discussionmentioning

confidence: 99%

“…Compounds that have been described as an etiology of pancreatitis include malathion, parathion, fenthion, coumaphos, diazinon, difonate, dimethoate, methomyl, meprobamate, carbofuran, dichlorvos, mevinphos, and propoxyfur [6, 7]. Studies in rats have shown that early and high dose atropine reduces incidence of pancreatitis by decreasing ductular pressure and also reducing histopathological changes in the pancreas [6]. Hyperamylasemia and severity of poisoning do not always correlate with pancreatitis in OPC poisoning [7], as in our patient where CT findings were surprisingly normal considering the enzyme elevations.…”

Section: Discussionmentioning

confidence: 99%

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Unusual Complications of Quinalphos Poisoning

Viswanathan

2013

Case Reports in Emergency Medicine

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This 40-year-old man was treated for suicidal quinalphos 25%EC consumption. He developed intermediate syndrome with normal response to repetitive nerve stimulation, pancreatitis with high enzyme elevations, and normal computed tomography and excreted black, brown, and orange urine sequentially over the first nine days of hospitalization. The last complication has not been previously reported with any organophosphate compound. He finally succumbed to complication of ventilator associated pneumonia related septic shock and ventricular tachycardia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unusual Complications of Quinalphos Poisoning

Viswanathan

2013

Case Reports in Emergency Medicine

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“…Intermediate syndrome causing respiratory failure is one of the most dreaded complications [3]. Although atypical complications like pancreatitis and haemolysis have been described [4, 5], only one case of blackish discoloration of urine has been reported in literature, following quinalphos poisoning [6]. This report describes two cases sharing this atypical manifestation, but due to different compounds.…”

Section: Introductionmentioning

confidence: 99%

Black Coloured Urine following Organophosphorus Poisoning: Report of Two Cases

Basheer

Mookkappan

Shanmugham

et al. 2014

Case Reports in Critical Care

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Organophosphorus poisoning is common in rural Asia. Clinical features result from overactivity of acetylcholine receptors. Blackish discoloration of urine is not a feature of organophosphorus poisoning. Only one case of black colored urine following quinalphos poisoning has been reported in literature. We report two cases of organophosphorus poisoning from two different compounds, following which patients passed black colored urine, in the absence of haemolysis or rhabdomyolysis. These cases indicate that blackish discoloration of urine in organophosphorus poisoning might not be as uncommon as it was believed to be. Besides, urinary excretion of metabolites might be an underlying mechanism, rather than hemolysis.

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AMELIORATIVE EFFECT OF POMEGRANATE MOLASSES ON DELTAMETHRIN INDUCED NEUROTOXICITY IN ADULT ALBINO RATS: BIOCHEMICAL, HISTOPATHOLOGICAL & IMMUNOHISTOCHEMICAL STUDY

Hussein

El-Shafey

Elshazly

2018

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

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Background: Deltamethrin (DLM) is class II synthetic pyrethroid used worldwide as pesticides in agriculture, household pest control, protection of foodstuff, and disease vector control. Exposures occur mainly from the household application, contaminated food or water. Although initially thought to be least toxic, a number of recent studies revealed its toxic effects in different animal species. Aim: The current study aimed to evaluate oxidative stress effect due to DLM exposure on brain tissues of adult albino rats, and whether co-administration of pomegranate (PM) molasses can ameliorate this oxidative damage. Materials & Methods: Thirty adult experimental Albino rats were divided into five groups:-ve control group (6 rats), +ve control group (6 rats) (received 1ml corn oil once daily, orally), diluted PM molasses [(0.5ml (PM) molasses+(0.5ml) distilled water] treated group (6 rats), DLM (6mg/kg) treated group (6 rats), DLM (6mg/kg) + diluted PM molasses[(0.5ml (PM) molasses+(0.5ml) distilled water] treated group (6 rats). These doses were given once daily, orally for seven days. By the end of the expirement, blood sample were obtained for estimation of plasma cholinesterase (PCHE) level and oxidative stress parameters) malondialdehyde [MDA], glutathione [GSH], and catalase [CAT] (, then rats were sacrificed. The brains were excised, prepared for estimation of oxidative stress parameters in tissue, histopathological changes and immunohistochemical examination. Results: revealed that DLM caused neurotoxicity in albino rats as there was a significant increase in serum & brain tissues MDA, reduction of both GSH & CAT, decrease in PCHE level & pathological changes in brain included, neuronal degeneration, apoptotic bodies, neuropil vacuolizations, proliferated and dilated blood vessels beside strong positive immunreaction for bax when compared with both control groups & PM molasses treated groups. While, there was significant reduction in serum & brain MDA, significant increase in both GSH &CAT and also decrease in PCHE level. Mild pathological changes in brain of albino rats beside mild positive immunreaction for bax in DLM + PM molasses treated group as compared to DLM treated group. Conclusion: deltamethrin can induce oxidative damage in the experimental albino rat brain & pomegranate molasses as an antioxidant has an ameliorative effect against this damage.

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Influence of atropine therapy on fenthion-induced pancreatitis

Abstract: Atropine administration influence on fenthion-induced pancreatitis should be studied for other organophosphates in animals and humans.

Cited by 3 publications

References 17 publications

Unusual Complications of Quinalphos Poisoning

Unusual Complications of Quinalphos Poisoning

Black Coloured Urine following Organophosphorus Poisoning: Report of Two Cases

AMELIORATIVE EFFECT OF POMEGRANATE MOLASSES ON DELTAMETHRIN INDUCED NEUROTOXICITY IN ADULT ALBINO RATS: BIOCHEMICAL, HISTOPATHOLOGICAL & IMMUNOHISTOCHEMICAL STUDY

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