Influence of Asthma Epidemiology on the Risk for Other Diseases

Juhn, Young J.

doi:10.4168/aair.2012.4.3.122

Cited by 15 publications

(19 citation statements)

References 82 publications

(81 reference statements)

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“…In our study, the highest incidence rate ratio was observed in children up to 10 years old for the asthma cohort and in adults aged 50-59 years old for the COPD cohort, where the incidence of Crohn's disease was more than double that in the general population. The findings of VIRTA et al [8] were also suggestive of an association between childhood asthma and Crohn's disease, while two other studies failed to find a significant association [28,29].…”

Section: Discussionmentioning

confidence: 90%

Increased incidence of inflammatory bowel disease in Québec residents with airway diseases

et al. 2014

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The objective of the study was to assess whether the incidences of Crohn's disease and ulcerative colitis are increased in patients with asthma and chronic obstructive pulmonary disease (COPD) compared to the general population.A population-based retrospective cohort study was conducted using the administrative health databases of Québec, Canada. Incidences of Crohn's disease and ulcerative colitis among patients with asthma and COPD were assessed for the 2001-2006 period.In total, 136 178 subjects with asthma and 143 904 subjects with COPD were identified. The average incidence of Crohn's disease and ulcerative colitis was 23.1 and 8.8 per 100 000 person-years among asthmatic patients; in the COPD cohort there were 26.2 Crohn's disease cases and 17 ulcerative colitis cases per 100 000 person-years. The incidence of Crohn's disease in asthma and COPD patients was 27% and 55% higher than in the general population of Québec; the incidence of ulcerative colitis was 30% higher among COPD patients compared to the general population.Incidence of inflammatory bowel disease was significantly increased in asthma and COPD patients compared to the general population of Québec. Incidence rates were particularly high in patients with COPD. Awareness of an association between airway diseases and inflammatory bowel disease in older age groups may play an important role in earlier detection of bowel disease and in the therapeutic management of such patients. @ERSpublications Patients with airway diseases have a higher incidence of inflammatory bowel disease than the general population

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Section: Discussionmentioning

confidence: 90%

Increased incidence of inflammatory bowel disease in Québec residents with airway diseases

et al. 2014

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“…Asthmatics may have increased susceptibility for H1N1pdm infection [45], possibly because of alterations in the airway architecture [46], [47] and impairment of innate immunity [47]. Another hypothesis to explain a higher GMT in subjects with such medical conditions, regardless of their susceptibility to infection, would be a more severe illness [48] involving a greater immune response [49].…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Post-Seasonal Serological Titer and Risk Factors for Infection with the Pandemic A/H1N1 Virus in the French General Population

et al. 2013

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The CoPanFlu-France cohort of households was set up in 2009 to study the risk factors for infection by the pandemic influenza virus (H1N1pdm) in the French general population. The authors developed an integrative data-driven approach to identify individual, collective and environmental factors associated with the post-seasonal serological H1N1pdm geometric mean titer, and derived a nested case-control analysis to identify risk factors for infection during the first season. This analysis included 1377 subjects (601 households). The GMT for the general population was 47.1 (95% confidence interval (CI): 45.1, 49.2). According to a multivariable analysis, pandemic vaccination, seasonal vaccination in 2009, recent history of influenza-like illness, asthma, chronic obstructive pulmonary disease, social contacts at school and use of public transports by the local population were associated with a higher GMT, whereas history of smoking was associated with a lower GMT. Additionally, young age at inclusion and risk perception of exposure to the virus at work were identified as possible risk factors, whereas presence of an air humidifier in the living room was a possible protective factor. These findings will be interpreted in light of the longitudinal analyses of this ongoing cohort.

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“…There are several potential causal relationships between atopic conditions and microbial infections or colonization: protective (eg, the “hygiene hypothesis”), 22,23 provocative (eg, rhinovirus or bacterial colonization), 24,25 and contextual effects (eg, the microbiome hypothesis), 26,27 as well as reverse causality 20,28-30 (Figure 1). This paper focuses on the effect of atopic conditions on the risk of infections, termed reverse causality .…”

Section: Effect Of Atopic Conditions On the Risk Of Microbial Infectionsmentioning

confidence: 99%

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

Juhn¹

2014

Journal of Allergy and Clinical Immunology

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128

124

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Most of the research effort regarding asthma has been devoted to its causes, therapy, and prognosis. There is also evidence that the presence of asthma can influence patients’ susceptibility to infections, yet research in this aspect of asthma has been limited. There is additional debate in this field, with current literature tending to view the increased risk of infection among atopic patients as due to opportunistic infections secondary to airway inflammation, especially in severe atopic diseases. Other evidence, however, suggests that such risk and its underlying immune dysfunction may be a phenotypic or clinical feature of atopic conditions. This review argues that 1) improved understanding of the effects of asthma or other atopic conditions on the risk of microbial infections will bring important and new perspectives to clinical practice, research, and public health concerning atopic conditions and that 2) research efforts into the causes and effects of asthma must be juxtaposed because they are likely to guide each other.

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Influence of Asthma Epidemiology on the Risk for Other Diseases

Cited by 15 publications

References 82 publications

Increased incidence of inflammatory bowel disease in Québec residents with airway diseases

Increased incidence of inflammatory bowel disease in Québec residents with airway diseases

Factors Associated with Post-Seasonal Serological Titer and Risk Factors for Infection with the Pandemic A/H1N1 Virus in the French General Population

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease?

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