“…Therefore, our study might provide limited generalizability for the application of IC-ECG guidance for ECC placement via the lower extremity in preterm infants. Second, we chose CXR to confirm the tip position, which is a relatively inaccurate, post-procedural, time-consuming, and harmful methodology, whereas real-time ultrasound is an accurate, intra-procedural, real-time, non-invasive, and safe methodology [ 15 , 26 ]. Growing evidence suggests that real-time ultrasound is more accurate than conventional radiology because of its direct visualization of all venous districts and the catheter tip [ 26 , 40 , 41 ].…”