Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine

Barbisan, Luı́s Fernando; Miyamoto, Masaomi; Scolastici, Clarissa; Salvadori, Daisy M.F.; Ribeiro, L.R; Eira, Augusto Ferreira da; Camargo, João Lauro Viana de

doi:10.1016/s0378-8741(02)00171-x

Cited by 48 publications

(30 citation statements)

References 24 publications

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“…Nevertheless, chemical toxins (including acetaminophen, carbon tetrachloride, thioacetamide, ethanol, D-galactosamine, diethylnitrosamine and dimethylnitrosamine) are often used as the model substances causing experimental hepatocyte injury under both in vivo and in vitro conditions [10,[34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Main Hepatotoxic Agents Used In Hepatoprotective Studiesmentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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Abstract:The particular characteristics of growth and development of mushrooms in nature result in the accumulation of a variety of secondary metabolites such as phenolic compounds, terpenes and steroids and essential cell wall components such as polysaccharides, β-glucans and proteins, several of them with biological activities. The present article outlines and discusses the available information about the protective effects of mushroom extracts against liver damage induced by exogenous compounds. Among mushrooms, Ganoderma lucidum is indubitably the most widely studied species. In this review, however, emphasis was given to studies using other mushrooms, especially those presenting efforts of attributing hepatoprotective activities to specific chemical components usually present in the mushroom extracts.

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Section: Main Hepatotoxic Agents Used In Hepatoprotective Studiesmentioning

confidence: 99%

Hepatoprotective Effects of Mushrooms

et al. 2013

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“…The biotransformation of DEN resulting in oxidative stress alters the structure of DNA and forming alkyl DNA adducts [5]. It has been proven that metabolic bioactivation of cytochrome p450 enzymes to reactive electrophiles is required for initiation of their cytotoxic, mutagenic and carcinogenic activity by the help of nitrosamines with hepatocyte proliferation following cell necrosis [6], hyperplasia, hyperbasophilia and tumour. The treatment of HCC is still a big challenge in medicine.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential Role of Chemopreventive Agent, Hesperetin Conjugated Pegylated Gold Nanoparticles in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Male Wistar Albino Rats

et al. 2015

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Liver cancer is the fifth most common cancer and is still one of the leading causes of death world wide, due to food additives, alcohol, fungal toxins, air, toxic industrial chemicals, and water pollutants. Chemopreventive drugs play a potential role in liver cancer treatment. Obviously in the production of anticancer drugs, the factors like poor solubility, bioavailability, biocompatibility, limited chemical stability, large amount of dose etc., plays a major role. Against this backdrop, the idea of designing the chemopreventive nature of bio flavanoid hesperetin (HP) drug conjugated with pegylated gold nanoparticles to increasing the solubility, improve bioavailability and enhance the targeting capabilities of the drug during diethylnitrosamine (DEN) induced liver cancer in male wistar albino rats. The dose fixation studies and the toxicity of pure HP and HP conjugated gold nanoparticles (AumPEG (5000) -S-HP) were analysed. After concluded the dose fixation and toxicity studies the experimental design were segregated in six groups for the anticancer analysis of DEN induced HCC for 16 weeks. After the experimental period the body weight, relative liver weight, number of nodules and size of nodules, the levels of tumor markers like CEA, AFP and the level of lipid peroxidation, lipid hydroperoxides and the activities of antioxidant enzymes were assessed. The administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma glutamyl transpeptidase. The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase, catalase, reduced glutathione, glutathione peroxidise, and glutathione reductase. HP supplementation (20 mg/kg b.wt) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer and the HP loaded gold nanoparticels (AumPEG (5000) -S-HP) treated animals shows the better treatment than the pure HP due to the solubility of drug, bioavailability and the target drug delivery of the biodegradable polymer. Histological observations were also carried out, which added supports to the chemopreventive action of the pure HP and HP loaded gold nanoparticles (Au-mPEG (5000) -S-HP) against DEN induction during liver cancer progression. These findings suggest that HP loaded gold nanoparticels (Au-mPEG (5000) -S-HP) shows better efficacy than the pure HP against lipid peroxidation, hepatic cell damage and protects the antioxidant system in DEN induced hepatocellular carcinogenesis.

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“…S100, which is a SC marker (31), was elevated when SCs received baicalin treatment, as demonstrated by the increased protein expression levels of S100 in baicalin-treated cells when compared with the control, via immunohistochemical examination. Natural substrates, such as traditional medicinal herbs, are well-known for their relatively minor adverse effects (32). Extracts from S. baicalensis are considered to exhibit low cytotoxicity (33) and have neuroprotective properties (34).…”

Section: Discussionmentioning

confidence: 99%

Baicalin promotes the viability of Schwann cells in vitro by regulating neurotrophic factors

Zuo

Zhang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The proliferation and migration of Schwann cells (SCs) are key events in the process of peripheral nerve repair. This is required to promote the growth of SCs and is a challenge during the treatment of peripheral nerve injury. Baicalin is a natural herb-derived flavonoid compound, which has been reported to possess neuroprotective effects on rats with permanent brain ischemia and neuronal differentiation of neural stem cells. The association of baicalin with neuroprotection leads to the suggestion that baicalin may exert effects on the growth of SCs. In the present study, the effects of baicalin on SCs of RSC96 were investigated. RSC96 SCs were treated with various concentrations of baicalin (0, 5, 10 or 20 µM) for 2, 4 and 6 days. Cell attachment, viability and gene expression were monitored via the MTT assay and reverse transcription-quantitative polymerase chain reaction. The gene expression levels of several neurotrophic factors, such as glial cell-derived neurotrophic factor, brain-derived neurotrophic factor and ciliary neurotrophic factor, which are considered important factors in the process of never cell regeneration, were detected. The results indicated that baicalin was able to promote the viability of RSC96 SCs in a dose-dependent manner and the concentration of 20 µM of baicalin exhibited the greatest cell viability and gene expression of the studied neurotrophic factors. The present findings suggested that baicalin likely affects SCs metabolism, through modulating the expression of neurotrophic factors. To conclude, the present study indicates that baicalin may be potential therapeutic agent for treating peripheral nerve regeneration.

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Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine

Cited by 48 publications

References 24 publications

Hepatoprotective Effects of Mushrooms

Hepatoprotective Effects of Mushrooms

Exploring the Potential Role of Chemopreventive Agent, Hesperetin Conjugated Pegylated Gold Nanoparticles in Diethylnitrosamine-Induced Hepatocellular Carcinoma in Male Wistar Albino Rats

Baicalin promotes the viability of Schwann cells in vitro by regulating neurotrophic factors

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