Influence of apolipoprotein E polymorphism on plasma vitamin A and vitamin E levels

Gómez-Coronado, Diego; Entrala, Alfredo; Álvarez, Juan José Criado; Ortega, Henar; Olmos, José María de Francisco; Castro, M. Fernández; Sastre, A; Herrera, Emilio; Lasunción, Miguel A.

doi:10.1046/j.1365-2362.2002.00983.x

Cited by 24 publications

(17 citation statements)

References 60 publications

(114 reference statements)

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“…Furthermore, the relationship between apo E variants and plasma concentration of a-tocopherol confirm previous findings (35,36). Indeed, as observed by Gomez-Coronado et al (35), we found that subjects bearing the E2 allele had lower a-tocopherol concentrations than those bearing the more common E3 allele. With the exception of the 4 E4-homozygous subjects, the subjects bearing the E4 allele had the higher a-tocopherol concentrations.…”

Section: Discussionsupporting

confidence: 92%

Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism , ,3

Borel

Moussa

Reboul

et al. 2007

The Journal of Nutrition

150

120

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Vitamin E and carotenoids are fat-soluble micronutrients carried by plasma lipoproteins. Their plasma concentrations are governed by several factors, some of which are genetic, but data on these genetic factors remain scarce. We hypothesized that genes involved in lipid metabolism, i.e. the genes implicated in intestinal uptake, intracellular trafficking, and the lipoprotein distribution of lipids, play a role in the plasma concentrations of these micronutrients. To verify this hypothesis, we assessed whether the plasma status of vitamin E and carotenoids is related to genes involved in lipid metabolism. Fasting plasma vitamin E (a-and g-tocopherol) and carotenoid (a-and b-carotene, lutein, lycopene, b-cryptoxanthin, and zeaxanthin) concentrations were measured in 48 males and 80 females. The following genes were genotyped [single nucleotide polymorphisms (SNP)]: apolipoprotein (apo) A-IV, apo B, apo E, lipoprotein lipase, and scavenger-receptor class B type I (SR-BI). Plasma a-tocopherol concentrations were different (P , 0.05) in subjects bearing different SNP in apo A-IV, apo E, and SR-BI. Plasma g-tocopherol concentrations were different (P , 0.05) in subjects bearing different SNP in apo A-IV and SR-BI. a-Carotene concentrations were different (P , 0.05) in subjects bearing different SNP in SR-BI. b-Carotene concentrations were different (P , 0.05) in subjects bearing different SNP in apo B and SR-BI. Lycopene concentrations were different (P , 0.05) in subjects bearing different SNP in apo A-IV and apo B. b-Cryptoxanthin concentrations were different (P , 0.05) in subjects bearing different SNP in SR-BI. Plasma lutein and zeaxanthin concentrations did not differ in subjects bearing different SNP. Most of the differences remained significant after the plasma micronutrients were adjusted for plasma triglycerides and cholesterol. These results suggest that genes involved in lipid metabolism influence the plasma concentrations of these fat-soluble micronutrients.

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Section: Discussionsupporting

confidence: 92%

Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism , ,3

Borel

Moussa

Reboul

et al. 2007

The Journal of Nutrition

150

120

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“…Our data suggest that the transport of a-tocopherol into the tissues may be altered by the apoE genotype, in which apoE4 show decreased a-tocopherol levels in tissues and increased levels in plasma. These data are supported by other reports showing increased plasma concentrations of a-tocopherol in apoE4 carriers [98,99].…”

Section: Antioxidant Supplysupporting

confidence: 91%

Impact of apoE genotype on oxidative stress, inflammation and disease risk

Jofre-Monseny

Minihane

Rimbach³

2008

Molecular Nutrition Food Res

266

215

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Although in developing countries an apolipoprotein E4 (apoE4) genotype may offer an evolutionary advantage, as it has been shown to offer protection against certain infectious disease, in Westernised societies it is associated with increased morbidity and mortality, and represents a significant risk factor for cardiovascular disease, late-onset Alzheimer's disease and other chronic disorders. ApoE is an important modulator of many stages of lipoprotein metabolism and traditionally the increased risk was attributed to higher lipid levels in E4 carriers. However, more recent evidence demonstrates the multifunctional nature of the apoE protein and the fact that the impact of genotype on disease risk may be in large part due to an impact on oxidative status or the immunomodulatory/anti-inflammatory properties of apoE. An increasing number of studies in cell lines, targeted replacement rodents and human volunteers indicate higher oxidative stress and a more pro-inflammatory state associated with the epsilon4 allele. The impact of genotype on the antioxidant and immunomodulatory/anti-inflammatory properties of apoE is the focus of the current review. Furthermore, current information on the impact of environment (diet, exercise, smoking status, alcohol) on apoE genotype-phenotype associations are discussed with a view to identifying particular lifestyle strategies that could be adapted to counteract the 'at-risk' E4 genotype.

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“…In our study, we found that patients with ε4+ at APOE had higher serum levels of ApoE and LDL-C, suggesting that SNPs at APOE are important contributors for the aggravation of CAD as they affect serum lipid levels. Meanwhile, APOE may also increase the risk of CAD through the interaction with the antioxidative and immune system [35], but more detailed mechanisms regarding the association of APOE and CAD need further investigation.…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study of the Association of the Polymorphisms of MTHFR and APOE with Risk Factors and the Severity of Coronary Artery Disease

et al. 2019

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Objectives: To explore the association between single-nucleotide polymorphisms (SNPs) in MTHFR and APOE and the risk of CAD and, more importantly, the severity of CAD and the profile of serum lipids, we performed a case-control study in a Chinese Han population. Methods: A total of 1,207 cases of consecutive CAD-suspected inpatients were recruited, and 406 CAD cases and 231 non-CAD controls were enrolled for the final analysis after screening for exclusion criteria. All subjects had undergone coronary angiography, and the severity of CAD was evaluated by 2 cardiologists according to the Gensini scores. The genotypes of MTHFR and APOEwere detected using real-time PCR, and then verified by Sanger sequencing. Environmental risk factors, such as age, sex, smoking, alcohol consumption, hypertension, diabetes, dyslipidemia, and BMI were collected. Statistical analyses (the χ² test, binary logistic regression analysis, and ordinal polytomous logistic regression analysis) were performed with SPSS v16.0. Results: The genotypes ofall the subjects included in the CAD and non-CAD groups in this study were successfully detected, with an agreement of 100% with Sanger sequencing. The distributions of genotypes CT and TT at MTHFR C667T were higher in CAD cases than in non-CAD controls (OR 1.99, 95% CI 1.34–2.95; OR 1.77, 95% CI 1.18–2.67; p < 0.05), whereas genotype AC at MTHFR A1298Cwas lower in CAD cases (OR 0.71, 95% CI 0.50–1.02; p < 0.05). A significant association was observed in genotypes CT and TT at MTHFR C667T and the risk of CAD (OR 1.44, 95% CI 1.27–3.67; OR 1.56, 95% CI 0.88–2.78; p < 0.05). Both genotypes and alleles of APOE were comparable in the CAD cases and non-CAD controls (p > 0.05). The genotype TT at MTHFR C667T and ε4+ at APOE were more likely to be found in the CAD subgroup with a Gensini score ≥72 (p = 0.040 and p = 0.028, respectively). Meanwhile, in the patients with genotype TT,a higher level of serum Hcy was detected, while genotype ε4+ patients possessed higher levels of serum apolipoprotein E (ApoE) and low-density lipoprotein cholesterol (LDL-C) than other genotypes. Conclusion: This study revealed that the SNP site of MTHFR C667Tis associatedwith the risk of CAD in this Chinese Han population. In addition, the genotypes of TT in MTHFR C667T and ε4+in APOE may increase the severity of CAD, and higher Hcy, LDL-C, and ApoE levels may be involved in this pathogenic process.

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Influence of apolipoprotein E polymorphism on plasma vitamin A and vitamin E levels

Cited by 24 publications

References 60 publications

Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism , ,3

Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism , ,3

Impact of apoE genotype on oxidative stress, inflammation and disease risk

A Case-Control Study of the Association of the Polymorphisms of <b><i>MTHFR</i></b> and <b><i>APOE</i></b> with Risk Factors and the Severity of Coronary Artery Disease

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