Influence of Antiretroviral Therapy on the Metabolic Profile of People Living with HIV Followed at University Hospital, Cotonou, Benin

Zannou, Djimon Marcel; Azon-Kouanou, Angèle; Ahomadegbe, Manoela Christelle; Agbodande, Kuessi Anthelme; Akakpo, Jocelyn; Dovonou, Comlan Albert; Amoussou-Guenou, K. Daniel; Tchabi, Y.; Adé, G; Houngbe, Fabien

doi:10.4236/ojim.2015.54015

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The most represented age group was 37 -42 years old. These results are close to studies carried out in Cotonou [17] which noted an average age of 38 and 41 years. The differences could be explained by the size of our larger samples and by the period of the studies being quite distant from each other.…”

Section: Discussionsupporting

confidence: 89%

Evolution of Viral Load in Patients Infected with HIV-1 at Point G University Hospital

Maiga,

Kone,

Coulibaly

et al. 2024

OJMM

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Introduction: HIV, the human immunodeficiency virus, is the etiological agent of acquired immunodeficiency syndrome (AIDS). The aim of this study was to assess the evolution of the viral load in patients under treatment. Methodology: This was a study carried out from July 2017 to June 2022 at the Point G University Hospital laboratory. The determination of the viral load of patients was carried out by PCR on the ABOTT M2000sp/rt platform. Results: A total of 129 patients infected with HIV-1, aged 19 to 72 years with a mean age of 40.05 years ± 10.71; all on antiretroviral chemotherapy. The female gender predominated among our patients. The most common treatment regimen was 2INTI + 1INNTI with 72.9% followed by 2INTI + 1INI with 13.2%. As for the combinations of molecules, the combination TDF + 3TC + EFV and TDF + 3TC + DTG predominated, respectively 65.1% and 13.2%. 89.9% of our patients had undetectable viremia after 12 months of treatment (p < 0.005) with an average viral load which had evolved from 681315.65 copies/ml ± 1616908.484 to M0 at 5742.36 copies /ml ± 35756.883 at M12 (p < 0.005). Conclusion: Generally speaking, antiretroviral treatment had contributed to controlling viral loads, however the therapeutic combination TDF + 3TC + DTG had made it possible to obtain more patients with undetectable viremia instead.

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Section: Discussionsupporting

confidence: 89%

Evolution of Viral Load in Patients Infected with HIV-1 at Point G University Hospital

Maiga,

Kone,

Coulibaly

et al. 2024

OJMM

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“…They ère followed by the deterioration of general condition, decompensated anemia and dehydration. That latter resulted from digestive disorders namely vomiting and diarrhea associated witz oral pharyngeal candidiasis very frequent in immunosuppression syndrome as reported by many authors [3,10,11].…”

Section: Discussionmentioning

confidence: 79%

Profile of People Living with HIV in Intensive Medical Care in Togo: Epidemiological and Evolutionary Aspects

Ma¹,

Sm²,

Balaka³

et al. 2015

J Hematol Thrombo Dis

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Aim:To describe both the epidemiology and prognosis of people living with HIV (PLHIV) hospitalized in intensive care.Methodology: It is a prospective cross-sectional study conducted at the CHU Sylvanus Olympio, Lomé over a period of 12 months on known HIV infected patients or patients newly diagnosed on admission, from both sexes, aged over 15 years, hospitalized during the period between January 1st and December 31st, 2011. We studied the socio-demographic parameters, the reason for hospitalization, the infections and affections found and and their evolution.Results: During our study period 124 patients (46 men and 78 women) ère selected out of 1130, i.e. a rate of 10.9%, witz a sex ratio of 0.6. The average age of our patients was 41 ± 15.5 years, ranging from 20 years to 69 years. On admission, 41% (51 patients) ère aware of their HIV-positive status, witz 30% on antiretroviral treatment. The reasons for admission ère dominâtes by altered consciousness, repetitive seizures, severe dehydration, severe anemia witz impaired general condition and paroxysmal dyspnées witz respective rates of 48.4%, 22, 6%, 12% 32% and 4.3%. The clinicat manifestations ère dominâtes by hémi corporal sensoriel motor deficit (56.7%), fever (53%) and coma (48.4%). Biologically, 83.6% had a CD4 rate below 200 elements per mm 3 . Anemia was severe in 32 % out of the 87% of cases of anemia. This anemia is associated witz a lymphopenia or neutropenia or thrombocytopenia in respectively 63.3%, 57.1% and 20% of cases. Creatinine and blood urea ère elevated in 20% of cases. Infections and diseases found ère dominâtes by cerebral abscesses (40%), severe anemia (32%), gastroenteritis (12%) and meningitis (11.2%). Brain abscess ère represented by toxoplasmosis in 90% of cases. Meningitis was bacterial in 5 cases (pneumococcus), fungal (Cryptococcus) in 3 cases. Overall mortality was 43% witz a higher lethality for meningitis and severe anemia. Conclusion:The proportion of patients witz HIV infection is high in medical intensive care unit in Togo. The admission patterns are dominâtes by neurological diseases including coma. Infections and/or affections are found but dominâtes by various cerebral abscesses (toxoplasmosis). Mortality in patients witz HIV infection in intensive care is high and seems to be improved by proper management of toxoplasmosis abscesses.

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Influence of Antiretroviral Therapy on the Metabolic Profile of People Living with HIV Followed at University Hospital, Cotonou, Benin

Cited by 2 publications

References 21 publications

Evolution of Viral Load in Patients Infected with HIV-1 at Point G University Hospital

Evolution of Viral Load in Patients Infected with HIV-1 at Point G University Hospital

Profile of People Living with HIV in Intensive Medical Care in Togo: Epidemiological and Evolutionary Aspects

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