Influence of Antiplatelet Drugs in the Pathogenesis of Experimental Periodontitis and Periodontal Repair in Rats

Coimbra, Leila S.; Rossa, Carlos; Guimarães, Morgana Rodrigues; Gerlach, Raquel Fernanda; Muscará, Marcelo N.; Spolidorio, Luís Carlos; Herrera, Bruno S.; Spolidório, Luís Carlos

doi:10.1902/jop.2010.100555

Cited by 35 publications

(38 citation statements)

References 45 publications

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“…On the one hand, in the periodontitis group, we observed spontaneous periodontal healing at 1, 2, or 4 weeks compared with baseline. This healing was characterized by a decreased surface of inflammatory infiltration, alveolar bone remodeling, and epithelial reattachment, confirming the results reported by Coimbra et al [38], who also observed significant repair of the soft tissue and regeneration of the alveolar bone in rats 15 days after ligature removal. On the other hand, we observed delayed periodontal healing in the stress group, and the periodontal breakdown was significantly more severe in the stress group than in the periodontitis group.…”

Section: Discussionsupporting

confidence: 90%

Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor

Zhao

Cheng

et al. 2012

Mediators of Inflammation

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Objective. To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. Methods. Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. Then, the rats were sacrificed at baseline and week(s) 1, 2, and 4. The periodontitis healing condition was assessed, and the expression of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and bFGF were tested by immunohistochemistry. Results. The stressed rats showed reduced body weight gain, behavioral changes, and increased serum corticosterone and ACTH levels (P < 0.05). The surface of inflammatory infiltrate, alveolar bone loss, attachment loss, and expression of IL-1β and TNF-α in the stress group were higher than those in the periodontitis group at weeks 2 and 4 (P < 0.05). Rats with experimental periodontitis showed decreased bFGF expression (P < 0.05), and the recovery of bFGF expression in the stress group was slower than that in the periodontitis group (P < 0.05). Negative correlations between inflammatory cytokines and bFGF were detected. Conclusion. Psychological stress could delay periodontitis healing in rats, which may be partly mediated by downregulation of the expression of bFGF in the periodontal ligament.

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Section: Discussionsupporting

confidence: 90%

Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor

Zhao

Cheng

et al. 2012

Mediators of Inflammation

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“…We hypothesized that androgens also play a role on bone and soft tissue metabolism during repair in females. One of the main advantages of the ligature‐induced periodontal disease model is the possibility to analyze the shift from the inflammatory response to the early phase of periodontal repair, which is marked by higher levels of cytokines and growth factors, polymorphonuclear leukocytes and osteoclasts; whereas both spontaneous repair of the soft tissues and alveolar bone regeneration are observed 15 days following ligature removal . Thus, the purpose of this study was to measure the impact of androgens and their receptors on periodontal tissues during periodontal repair in female rats.…”

Section: Introductionmentioning

confidence: 99%

The role of androgens on periodontal repair in female rats

Steffens

Santana

Pitombo

et al. 2018

Journal of Periodontology

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“…Regardless, the involvement of LL-37 may represent an important link between enhanced inflammation and purinergic signaling. The recent observation that the P2Y 12 antagonist clopidogrel (Plavix) reduced levels of IL-6 and TNF-α in a rat model of periodontal disease supports the pro-inflammatory role of extracellular ATP (Coimbra et al, 2011).…”

Section: Atp and Gingival Cellsmentioning

confidence: 90%

Inflammation, Pain, and Pressure—Purinergic Signaling in Oral Tissues

Lim

Mitchell

2012

J Dent Res

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Signaling by extracellular purines such as ATP and adenosine has implications for dental research on multiple levels, with the association of purinergic signaling with inflammation, mechanical strain, and pain making the system particularly relevant for the specific challenges in the oral cavity. Oral tissues express a variety of G-protein-coupled P2Y receptors for ATP and P1 receptors for adenosine in addition to ionotropic P2X receptors for ATP. When these receptors are combined with the plethora of extracellular enzymes capable of manipulating extracellular agonist levels, a complex system for regulating oral health emerges, and recent findings have begun to identify a key role for purinergic signaling in oral pathophysiology. For example, the manipulation of extracellular ATP levels by P. gingivalis reduces inflammasome activation and apoptosis linked to P2X 7 receptor activation. Release of ATP by periodontal ligaments may link mechanical strain to bone remodeling. Activation of P2X receptors is implicated in dental pain, and receptor antagonists represent important targets for new analgesics. Altered levels of adenosine receptors in periodontal disease also suggest a role for nucleosides in dental signaling. The intricacies of the purinergic signaling system make it well-suited for the unique concerns of dental research, and future findings will doubtless confirm this importance.

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Influence of Antiplatelet Drugs in the Pathogenesis of Experimental Periodontitis and Periodontal Repair in Rats

Abstract: Systemic administration of Asp and Clo attenuates the inflammation associated with periodontitis without affecting the repair process when stimulus is removed.

Cited by 35 publications

References 45 publications

Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor

Psychological Stress Delays Periodontitis Healing in Rats: The Involvement of Basic Fibroblast Growth Factor

The role of androgens on periodontal repair in female rats

Inflammation, Pain, and Pressure—Purinergic Signaling in Oral Tissues

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