Influence of antioxidant vitamins supplementation on blood glucose levels and body wastages of alloxan-induced diabetic rats

Abstract

There is increasing evidence that in certain pathology states, the increased production and/or ineffective scavenging of reactive oxygen species (ROS) may play a critical role. Therefore, it seems reasonable that antioxidants can play an important role in the management of these diseases. In the current study, antioxidant vitamins A, C and E were supplemented in alloxan-induced diabetic rats for a period of 28 days. Blood glucose level was assayed by the method of Trinder (1969) and digital bench weigh balance was used to measure the weights. Final blood glucose concentrations were 4.16 ± 0.18 mmo/L in control, 5.94 ± 0.21 mmol/L in diabetic treated not supplemented and 4.56 ± 0.61 mmol/L in diabetic rats supplemented with vitamins. There were statistically significance deference, (P<0.05) between the supplemented and unsupplemented. Finally body weights were 157.57 ± 4.16 g in controls, 143.43 ± 8.70 g in diabetic not supplemented and 187.29±4.30 g in diabetic rats supplemented with vitamins. There were statistically significance difference between the supplemented and unsupplemented groups (P< 0.05). These findings suggest, in addition to oral hypoglycaemic agents, supplementation with antioxidant vitamins may improve glycaemic control and alleviates body wastage in alloxan-induced diabetic rats.

Evaluation of Antidiabetic Effect of Crude Aqueous Extract of Nut, Leaf and Stem Parts of Vigna subterranae on Streptozotocin-Induced Diabetic Rats

“…When plant extracts was received, the levels of urea, creatine, and uric acid significantly decreased (P≤ 0.05), easing the impaired effect. The accelerated breakdown of liver and plasma proteins that occurs with gluconeogenesis associated with hyperglycemia may be to blame for the rise in urea levels seen in diabetes [31].…”

“…Studies have also shown that patients with diabetes exhibit changes in their hematological indices, Patients with diabetes experience persistent high blood sugar levels, which can lead to the glycation of various proteins involved in clotting mechanisms, such as hemoglobin, prothrombin, and fibrinogen, in addition to red blood cells [31]. This alteration in hematology indices is a consequence of the glycation process [32].…”

Tetrahydrobiopterin Administration Restores Sex Hormones Imbalance in Streptozotocin-induced Diabetic Rats

“…About 5 mls of blood sample was obtained through cardiac puncture and divided into fluoride oxalate and lithium heparin anti-coagulated containers. Humane procedure was used as adopted [13]. Blood samples were centrifuged at 3000 rpm for five (5) minutes and plasma obtained was used for analysis.…”

The Effects of Zinc and Vitamin C Supplementation on the Glycemic Profile in Type 2 Diabetic Patients

“…This leads to the exhaustion of beta cells and, upon prolonged hyperglycemia, their apoptosis, causing progression of the disease [13]. Accordingly, the secretion of insulin is strictly controlled by glucose, other hormones, and the autonomic nervous system [14]. Glycated haemoglobin is an indirect measure of average blood glucose levels [15].…”