Influence of Antiinflammatory Drugs (Methylprednisolone and Diclofenac Sodium) on Experimental Pleurodesis Induced by Silver Nitrate or Talc

Nonsteroidal Anti-Inflammatory Drugs Alter the Human Mesothelial Pleural Permeability via Ion Cellular Transportation by Inhibiting Prostaglandin Synthesis

“…These selective inhibitors were considered to offer a better inflammatory pleural response in pleurodesis [17], thereby overcoming the decreased quality of pleural adhesions during pleurodesis induced by the nonselective NSAIDs [1,6,18]. Celecoxib, on the other hand, is considered to inhibit Na + channels in dorsal root ganglion neurons [14] or in rat retinal neurons [15].…”

“…In pleura, the anti-inflammatory drugs, and more specifically NSAIDs, are thought to play an important role in exudate progression [4] while they are shown to interfere with the pleurodesis quality [5,6]. Furthermore, histamine, an inflammatory hormone, was shown to cause permeability alterations in human parietal pleura mainly by interacting with the H 1 histaminic receptors and eventually interfering with the normal process of transmesothelial ion transportation [7].…”

Experimental Pleurodesis Induced by Antibiotics (Macrolides or Quinolones)

“…The degree of pleural adhesion after the intrapleural injection of these drugs was notably inferior to that observed in a prior study after the pleural instillation of talc (2.2 ± 0.7) or silver nitrate (3.2 ± 1.1). 12 The choice of an ideal pleural sclerosing agent is still object of research and is based on efficacy, morbidity-mortality, ease in manipulation, availability, and cost. It is note worthy that although the century have elapsed since pleurodesis was first performed (1901) 2,7 , the ideal agent only have far been identified.…”

“…8,11,12 After anesthesia by intramuscular injection (35 mg/kg of ketamine HCl and 5 mg/kg of xylazine hydrochloride), the animals were prepared for aseptic surgery. After an incision (0.5 cm) in the right hemithorax, the parietal pleura was exposed and the sclerosing agent was injected into the pleural space through a drain (6F); the surgical wound was closed by sutures.…”

“…Such scores were established in order to macroscopically quantify the degree of pleural adhesion (0-4), atelectasis (0-2), and fluid collection (0-4). Pleurodesis was considered effective when the degree of pleural adhesions was equal to or greater than a score of 3 [11][12][13][14][15][16] and no presence of atelectasis or fluid collection. Table 1 also shows the scores used to quantify collected fragments of pleura and parenchyma; these were processed and stained with hematoxylin and eosin.…”