2015
DOI: 10.1111/1755-5922.12136
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Influence of Antihypertensive Therapy on Cerebral Perfusion in Patients with Metabolic Syndrome: Relationship with Cognitive Function and 24‐h Arterial Blood Pressure Monitoring

Abstract: SUMMARYAims: To investigate the regional cerebral blood flow, cognitive function, and parameters of 24-h arterial blood pressure monitoring in patients with metabolic syndrome before and after combination antihypertensive therapy. Methods: The study involved 54 patients with metabolic syndrome (MetS) investigated by brain single-photon emission computed tomography, 24-h blood pressure monitoring (ABPM), and comprehensive neuropsychological testing before and after 24 weeks of combination antihypertensive thera… Show more

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Cited by 12 publications
(11 citation statements)
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“…One previous study found no effect of discontinuation of AHD on ASL measured CBF, while another reported that introduction of AHD treatment in patients with metabolic syndrome increased CBF, measured using SPECT. 26,29 This may be explained by the relation between AHD and CBF being specific to certain AHD types, concurring with a growing number of reports that suggest specific AHD types convey a lower risk of dementia. 2,30,31 Several mechanisms have been hypothesized to explain this phenomenon.…”
Section: Discussionsupporting
confidence: 74%
“…One previous study found no effect of discontinuation of AHD on ASL measured CBF, while another reported that introduction of AHD treatment in patients with metabolic syndrome increased CBF, measured using SPECT. 26,29 This may be explained by the relation between AHD and CBF being specific to certain AHD types, concurring with a growing number of reports that suggest specific AHD types convey a lower risk of dementia. 2,30,31 Several mechanisms have been hypothesized to explain this phenomenon.…”
Section: Discussionsupporting
confidence: 74%
“…Metabolic syndrome additionally contributes to development of cognitive decline and depression in patients with CSVD, impairing indirectly overall functional capabilities of the patients, and making them more dependent. Timely and appropriate (according to current guidelines) treatment of metabolic syndrome may prevent or postpone its complications, including cognitive decline [14] [22] and depression [23]. Although this was not shown in the subset of patients with both CSVD and metabolic syndrome, it seems plausible that early treatment of metabolic syndrome in patients with CSVD would result with better functional outcome, and therefore decrease the burden of dependence on carers and society in general.…”
Section: Discussionmentioning
confidence: 99%
“…The influence and optimal degree of blood pressure management on CBF has been controversial. Although findings suggest that antihypertensive treatment can repress the progression of WMHs volume over time (64,65), there was weak evidence from other follow-up studies that found no CBF changes or even increased CBF after antihypertensive use (62,66). However, some aggressive blood pressure management would impair cerebral autoregulation.…”
Section: Discussionmentioning
confidence: 96%