Influence of antidepressant drugs administration on the morphine inhibitory effect in mice vasa deferentia

Moreno-Brea, M.R.; Gibert-Rahola, J.; Micó, Juan Antonio

doi:10.1016/0024-3205(95)02185-l

Cited by 1 publication

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“…The analgesic effect of some antidepressants and their potentiation of morphine-induced analgesia has been shown previously and proposed to be related to activation of the endogenous opioid system, which may also be mediated by serotonin (Sacerdote et al 1987;Ventafridda et al 1990). In agreement with the results obtained by Moreno-Brea et al (1995), our results show that the opioid receptor antagonist, naloxone, reduced the antinociceptive effect induced by imipramine plus morphine or slightly that of imipramine in the second phase of the test, indicating that the imipramine response may be associated with an opioid receptor mechanism. However, Sierralta et al (1995) reported that the opioid antagonist is not able to inhibit the imipramine response.…”

Section: Discussionsupporting

confidence: 92%

Effect of Imipramine on Tolerance to Morphine Antinociception in the Formalin Test

Zarrindast¹,

Shaverdian

Sahebgharani

2000

Pharmacology & Toxicology

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In this study, the effect of imipramine on morphine antinociception in tolerant and non-tolerant mice in the formalin test, was investigated. Subcutaneous administration of different test doses of morphine (3, 6 and 9 mg/kg) and intraperitoneal injection of test doses of imipramine (10, 20 and 40 mg/kg) induced a dose-dependent antinociception in non-tolerant mice, both in the first and second phases of the formalin test. The combination of morphine (1 mg/kg) with imipramine (10 mg/kg) showed a potentiated response in the second phase of the test. Combination of a single dose of morphine (1.5 mg/kg) with lower doses of imipramine (2, 4 and 8 mg/kg) did not show potentiation. The antinociceptive response of either morphine or morphine plus imipramine was reduced by the opioid receptor antagonist naloxone (2 mg/ kg). In order to induce tolerance, mice were treated subcutaneously with morphine (50 mg/kg) once daily for 3 days. On day 4, the antinociceptive effect of test doses of morphine or imipramine were assessed. Tolerance to the responses of test doses of morphine (3, 6 and 9 mg/kg), but not imipramine (10, 20 and 40 mg/kg) in both phases of the test was observed. Administration of lower dose of imipramine (4 mg/kg) before the test doses of morphine (3, 6 and 9 mg/kg) was not able to alter the expression of morphine tolerance. When imipramine was used during development of tolerance, either on days 1 and 2 or on days 2 and 3, the morphine tolerance in the second phase of the test was reduced. It is concluded that opioid receptor mechanism(s) may mediate the antidepressant-induced antinociception, however, imipramine may be useful in inhibiting morphine tolerance.

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