Influence of antagonist sensory and sympathetic nerves on smooth muscle cell differentiation in hypercholesterolemic rat

Increased stiffness and cell–matrix interactions of abdominal aorta in two experimental nonhypertensive models

“…Nevertheless, the small increase of EIIIA Fibronectin observed is independent of the blood pressure level, as guanethidine significantly reduced blood pressure in SNX rats compared with control. Our data support the concept that sympathectomy favors the expression of the immature phenotype of smooth muscle [28][29][30].…”

Trophic action of sympathetic nerves reduces arterial smooth muscle Ca2+sensitivity during early post-natal development in rats

“…To the best of our knowledge, data supporting our observations only exist for h-caldesmon (Kacem et al 2006, Hachani et al 2010. The expression levels of RhoK did not differ between denervated and control arteries.…”

“…In blood vessels, trophic actions of the sympathetic nerves increase expression of smooth muscle myosin and a-actin (Damon 2005, Hachani et al 2010, desmin and h-caldesmon (Hachani et al 2010) and the intercellular junction protein connexin (Slovut et al 2004); they also alter the membrane potential (Abel & Hermsmeyer 1981) and plasma membrane channel and pump activities (Fleming 1999). However, it remains unknown if and how the trophic actions of sympathetic nerves affect the Ca 2+ sensitivity of smooth muscle myofilaments during post-natal development.…”

Renal Denervation Promotes Atherosclerosis in Hypertensive Apolipoprotein E-Deficient Mice Infused with Angiotensin II

“…A number of previous experimental studies have reported that sympathetic denervation promoted atherosclerosis at sites remote to the denervation procedure (Murphy et al, 1957; Snyder and Campbell, 1958; Kacem et al, 1997, 2006; Kacem and Sercombe, 2008; Hachani et al, 2010). Bilateral surgical lumbar sympathectomy has been reported to increase atherosclerosis severity in the thoracic and abdominal aorta, and iliac and femoral arteries in rabbits fed a high cholesterol diet (Murphy et al, 1957; Snyder and Campbell, 1958).…”

“…A number of experimental studies suggest that both chemical and surgical sympathetic denervation promote atherosclerosis (Murphy et al, 1957; Snyder and Campbell, 1958; Kacem et al, 1997, 2006; Kacem and Sercombe, 2008; Hachani et al, 2010). A recent study reported that RDN inhibited atherosclerosis formation in normotensive apolipoprotein E-deficient (ApoE −/− ) mice fed a high-fat diet (Wang et al, 2015).…”