Influence of anionic surfactants on the sensitisation of the fluorimetric determination of fenproporex

Galdú, M. V.; Guárdia, Miguel de la; Braco, Lorenzo

doi:10.1039/an9871201047

Cited by 8 publications

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“…A Brookfield LVF model rotational viscosimeter has been employed and al1 the measurements have been carried out with a cylindricai cell9 cm long and 3-5 cm in diameter, with a spindle # 1 at speeds of 30 and 60rpm. 17 The fluorescence spectra of the benzodiazepines, in the different micellar media studied and in their absence, have been registered with a Shimadzu RF-520 spectrofluorometer equipped with a xenon lamp, a U-135s recorder and lcm quartz cells. The MEF values of the benzodiazepines in micellar media have been determined according to the experimental procedure proposed in Reference 22.…”

Section: A Pparatusmentioning

confidence: 99%

“…'~~'~ Viscosity measurements can also be used. 17 To relate these magnitudes to the condensation degree, simple mathematical models are proposed (linear, semilogarithmic or double logarithmic regressions). However, with these models the problem arises that small variations in the hydrophobic moiety composition make the use of different empirical laws necessary.…”

Section: Introductionmentioning

confidence: 99%

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The use of topological models in analytical chemistry

Guárdia¹,

Carrión²,

Galdú³

2005

J. Chemometrics

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In the present paper, the possible analytical applications of two topological models, the DARC model and the group contribution model, are discussed. Both models are applied to obtain calibration laws, which relate UV and IR characteristics with the chemical structure of ethylene oxide condensates.The group contribution model is also applied to determine the contribution of each part of the different compounds involved in a chemical interaction process, having established the sensitization parameters of benzodiazepines and anionic surfactants from the micellar enhancement fluorescence. KEY WORDS Topological description of molecules Infrared and ultraviolet spectroscopy Surfactants Benzodiazepines Interaction processes 0886-9383/88/060193-15$07.50

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Section: A Pparatusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The use of topological models in analytical chemistry

Guárdia¹,

Carrión²,

Galdú³

2005

J. Chemometrics

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Fluorescence in Organized Assemblies

Hinze¹

2000

Encyclopedia of Analytical Chemistry

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This article provides an overview of the general properties of organized assembly (ordered media) systems such as aqueous surfactant and bile salt micelles, lipid and surfactant vesicles (liposomes) and cyclodextrins (CDs) and summarizes their utilization to enhance the performance of analytical fluorescence measurements. In many instances, organic molecules and metal complex species, when included within a CD cavity or solubilized and bound to surfactant aggregates, exhibit enhanced fluorescence. This gives rise to improved detectability of such analytes. The altered microenvironment within the organized medium is capable of impeding the interfering action of other species (inorganic or organic) present in the sample matrix. This often can improve the selectivity of the analytical method. These benefits of improved sensitivity and selectivity arise from the compartmentalization, isolation and shielding of the excited singlet state of the guest analyte from quenching and nonradiative decay processes as well as prevent side reactions that otherwise can occur in bulk solution (or sample matrix). In addition, organic solvents or time‐consuming extraction steps can be avoided owing to the increased solubility of the nonpolar organic or inorganic reagents and/or analyte molecules in water in the presence of the organized medium; allowing for the use of an aqueous medium to perform the procedure. The possibility of conducting reactions and forming fluorescent organic or metal chelates in micellar (or other organized) media that are not observed in a bulk homogeneous solvent system serves to expand the scope of chemistries that one can consider using to design/develop new, unique and improved fluorescent assays. Numerous representative examples of fluorescent methods for determination of both organic and inorganic analytes are provided which serve to illustrate the advantages and benefits accrued from the use of the micelles, vesicles, liposomes or CDs in such procedures. Some experimental considerations and cautions to keep in mind when utilizing organized media are also delineated. An extensive reference section is provided so that the interested reader can easily refer to such for more detailed information on these systems and topics.

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Fluorescence in Organized Assemblies

Memon¹,

Balouch²,

Hinze³

2008

Encyclopedia of Analytical Chemistry

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This article provides an overview of the general properties of organized assembly (ordered media) systems, such as aqueous surfactant and bile salt micelles, lipid (liposomes) and surfactant vesicles, and cyclodextrins (CDs), and summarizes their utilization to enhance the performance of analytical fluorescence measurements. In many instances, organic molecules and metal complex species when included within a CD cavity or solubilized and bound to surfactant aggregates exhibit enhanced fluorescence, improving detectability of such analytes. The altered microenvironment within the organized medium can impede the interfering action of other species (inorganic or organic) present in the sample matrix, which often improves the selectivity of the analytical method. These benefits of improved sensitivity and selectivity arise from the compartmentalization, isolation, and shielding of the excited singlet state of the guest analyte from quenching and nonradiative decay processes, as well as preventing side reactions that otherwise can occur in bulk solution (or sample matrix). Organic solvents or time‐consuming extraction steps can also be avoided, owing to the increased solubility of nonpolar organic or inorganic reagents and/or analyte molecules in water in the presence of the organized medium, allowing the use of an aqueous medium to perform the procedure. The possibility of conducting reactions and forming fluorescent organic or metal chelates in micellar (or other organized) media that are not observed in a bulk homogeneous solvent system serves to expand the scope of possible chemistries for design/development of new, unique, and improved fluorescent assays. Examples of fluorescent methods for determination of both organic and inorganic analytes are provided, which serve to illustrate the advantages and benefits accrued from the use of the micelles, vesicles, liposomes, or CDs in such procedures, along with experimental considerations and cautions in utilizing organized media.

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Influence of anionic surfactants on the sensitisation of the fluorimetric determination of fenproporex

Cited by 8 publications

References 0 publications

The use of topological models in analytical chemistry

The use of topological models in analytical chemistry

Fluorescence in Organized Assemblies

Fluorescence in Organized Assemblies

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