Influence of Angiotensin Antagonists on Renal Vascular Resistance and Prostaglandin E Release

Sugawara, Shouma; Zimmerman, Ben G.

doi:10.3109/10641967809068592

Cited by 5 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have also considered the involvement of PGE in the renal vasodilator effect of saralasin in this study. This action of saralasin has been examined previously in our laboratory (Sugawara & Zimmerman, 1978). In that study collection of prostaglandin samples was carried out before and 15 min after beginning the infusion of saralasin.…”

Section: Discussionmentioning

confidence: 99%

Graded Effects of Saralasin on Prostaglandin E, Plasma Renin Activity and Renal Blood Flow in Anaesthetized Dogs

Wong

Zimmerman

1983

Clin Exp Pharma Physio

View full text Add to dashboard Cite

The objective of this study was to examine in anaesthetized dogs the graded effect of saralasin on renal prostaglandin E (PGE) release and to attempt to associate this change with its effects on plasma renin activity and renal blood flow. Blood pressure and renal blood flow were monitored. Renal PGE concentration and plasma renin activity were measured by radioimmunoassay. Saralasin or saline vehicle was infused into the renal artery for 20 min. Infusion of saralasin at the lowest dose of 0.25 micrograms/kg per min or saline vehicle did not alter either renal blood flow or plasma renin activity. Saralasin increased renal blood flow and caused a complete blockade of the renal vasoconstrictor response to exogenous angiotensin II at the two higher doses used (0.5 and 1 micrograms/kg per min). Only the highest dose of saralasin increased plasma renin activity significantly. Renal venous PGE concentration at the 5, 10 and 20 min periods of infusion was not changed significantly by any of these three doses of saralasin. We conclude therefore that the increases in renal blood flow and plasma renin activity caused by saralasin in the anaesthetized dog occur by mechanisms independent of changes in renal PGE.

show abstract

Section: Discussionmentioning

confidence: 99%

Graded Effects of Saralasin on Prostaglandin E, Plasma Renin Activity and Renal Blood Flow in Anaesthetized Dogs

Wong

Zimmerman

1983

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

Renal Prostaglandins and Other Eicosanoids

Conrad

Dünn

1992

Comprehensive Physiology

View full text Add to dashboard Cite

The sections in this article are: Biochemistry Eicosanoid Synthesis Eicosanoid Degradation Lipoxygenase and Epoxygenase Derivatives of Arachidonic Acid Sites of Renal Eicosanoid Synthesis Mechanism of Peptide Hormone Stimulation of Eicosanoid Synthesis Eicosanoid Receptors and Mechanism of Action of Eicosanoids Prostaglandin Excretion and Secretion Influence of Prostaglandins on Renal Blood Flow and Glomerular Filtration Rate Administration of Prostaglandins and Their Precursors Influence of Cyclooxygenase Inhibition on Renal Blood Flow and Glomerular Filtration Role of Prostaglandins in Renal Autoregulation and Tubuloglomerular Feedback Hormonal Stimulation of Renal Prostaglandin Synthesis Peptide Hormones and Prostaglandin Interactions in the Control of Renal Blood Flow Some Conditions in Which Prostaglandins Exert an Important Vasodilatory Action Summary: Prostaglandins and Renal Hemodynamics Prostaglandins and Renal Water Excretion Capacity of Renal Prostaglandins to Modulate Water Excretion in the Presence of Vasopressin Capacity of Renal Prostaglandins to Modulate Water Excretion When Vasopressin Is Absent or Severely Reduced Vasopressin and Vasopressin Analogs Stimulate Prostaglandin Synthesis in the Kidney Mechanisms by Which Prostaglandins Modulate Renal Water Excretion Prostaglandin Antagonism of AVP ‐Stimulated Water Flow: A Physiologic Phenomenon Mediated through the cyclic‐ AMP System? Summary: Prostaglandins and Renal Water Excretion Staglandins and Sodium Excretion Influence of Prostaglandins and Arachidonic Acid on Renal Sodium Excretion Cyclooxygenase Inhibition and Renal Sodium Excretion Effect of Sodium Intake on Renal Prostaglandin Synthesis and Excretion Nephron Sites Where Prostaglandins Oppose Sodium Absorption Summary: Prostaglandins and Sodium Excretion Contribution of Prostaglandins to the Renal Release of Renin Effects of Exogenous Prostaglandins and Arachidonic Acid on Renal Renin Release Influence of Cyclooxygenase Inhibition on Renal Renin Release Renin Release by the β‐Adrenergic, Renal Baroreceptor, and Macula Densa Mechanisms: Role of Prostaglandins Summary: Prostaglandins and Renin Release Prostaglandins as Mediators of Erythropoietin Release Effect of Prostaglandins on Tubular Transport of Calcium, Phosphate, and Magnesium, and on Renal Ammoniagenesis Calcium Phosphate Magnesium Renal Ammoniagenesis

show abstract

Effects of two angiotensin II analogues on blood pressure, plasma aldosterone concentration, plasma renin activity and creatinine clearance in normal subjects on different sodium intakes

Hata

Ogihara

Mikami

et al. 1980

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Two angiotensin II analogues (AIIA), 1-sarcosine, 8-isoleucine angiotensin II ([Sar, Ile]-AII) and 1-sarcosine, 8-alanine angiotensin II ([Sar, Ala]-AII), were infused in six normal volunteers on high, regular and low sodium diets. The agonist and antagonist activities of these AIIA on blood pressure (BP), plasma aldosterone concentration (PAC), creatinine clearance and plasma renin activity were examined. Both AIIA had agonistic pressor activities in subjects on high and regular sodium diets, [Sar, Ile]-AII being more potent than [Sar, Ala]-AII. Both AIIA caused similar elevation of PAC in subjects on high and regular sodium diets, and an equally fall in PAC in subjects on a low sodium diet. Both AIIA strongly antagonized the rise in BP, the increase in PAC and the reduction of Ccr induced by AII administration in subjects on all three sodium diets. The results indicate that both AIIA can be used to examine the activity of the renin-angiotensin system in patients with hypertension, and they also suggest that AII interaction with its receptors differs in different target tissues.

show abstract

Influence of Angiotensin Antagonists on Renal Vascular Resistance and Prostaglandin E Release

Cited by 5 publications

References 17 publications

Graded Effects of Saralasin on Prostaglandin E, Plasma Renin Activity and Renal Blood Flow in Anaesthetized Dogs

Graded Effects of Saralasin on Prostaglandin E, Plasma Renin Activity and Renal Blood Flow in Anaesthetized Dogs

Renal Prostaglandins and Other Eicosanoids

Effects of two angiotensin II analogues on blood pressure, plasma aldosterone concentration, plasma renin activity and creatinine clearance in normal subjects on different sodium intakes

Contact Info

Product

Resources

About