Influence of Anesthetic Agent on Response to Hemorrhagic Hypotension

Theye, Richard A.; Perry, Lawrence B.; Brzica, Stephen M.

doi:10.1097/00000542-197401000-00010

Cited by 12 publications

(2 citation statements)

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“…Opioids are not generally recommended as the sole anesthetic agent 5 . Inhalation anesthetics, such as halothane or isoflurane, are commonly used to maintain anesthesia, thus, various anesthetic techniques using a combination of injectable agents and inhalants have been used in hypovolemia 8–10 . In a previous study, anesthesia maintained with halothane was related to the longest survival time in a canine hemorrhage model 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Inhalation anesthetics, such as halothane or isoflurane, are commonly used to maintain anesthesia, thus, various anesthetic techniques using a combination of injectable agents and inhalants have been used in hypovolemia 8–10 . In a previous study, anesthesia maintained with halothane was related to the longest survival time in a canine hemorrhage model 8 . In another study in hypovolemic dogs, halothane induced a slight increase in blood pressure and cardiac index 30 minutes after administration 1…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular effects of desflurane following acute hemorrhage in dogs

Santos¹,

Andrade²,

Selmi³

et al. 2003

J Vet Emergen Crit Care

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiovascular effects of desflurane following acute hemorrhage in dogs

Santos¹,

Andrade²,

Selmi³

et al. 2003

J Vet Emergen Crit Care

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Physiologic Responses to Massive Intraoperative Hemorrhage

Waxman¹

1982

Arch Surg

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Molecular dynamics simulations using the drude polarizable force field on GPUs with OpenMM: Implementation, validation, and benchmarks

et al. 2018

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Presented is the implementation of the Drude force field in the open-source OpenMM simulation package allowing for access to graphical processing unit (GPU) hardware. In the Drude model, electronic degrees of freedom are represented by negatively charged particles attached to their parent atoms via harmonic springs, such that extra computational overhead comes from these additional particles and virtual sites representing lone pairs on electronegative atoms, as well as the associated thermostat and integration algorithms. This leads to an approximately fourfold increase in computational demand over additive force fields. However, by making the Drude model accessible to consumer-grade desktop GPU hardware it will be possible to perform simulations of one microsecond or more in less than a month, indicating that the barrier to employ polarizable models has largely been removed such that polarizable simulations with the classical Drude model are readily accessible and practical.

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Influence of Anesthetic Agent on Response to Hemorrhagic Hypotension

Cited by 12 publications

References 0 publications

Cardiovascular effects of desflurane following acute hemorrhage in dogs

Cardiovascular effects of desflurane following acute hemorrhage in dogs

Physiologic Responses to Massive Intraoperative Hemorrhage

Molecular dynamics simulations using the drude polarizable force field on GPUs with OpenMM: Implementation, validation, and benchmarks

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