Influence of anEleutherococcus extract on the induction of recessive lethal mutations by cyclophosphane and N-nitrosomorpholine onDrosophila

Sakharova, T. A.; Revazova, Yu. A.; Barenboim, G. M.

doi:10.1007/bf00766333

Cited by 1 publication

(2 citation statements)

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“…[1][2][3][4]9,26,27,69,71,474 Extensive research on E. senticosus reveals its antitoxic, neuroprotective, hepatoprotective, cardioprotective, antioxidant, immunomodulating, and antiviral activities along with stress-protective, antifatigue, hypoglycaemic, antidepressant and antiproliferative effects. 3,8,46,[474][475][476][477][478][479][480][481] As an example, E. senticosus inhibits the cadmium-induced apoptosis and mitosis of hepatocytes in mice, and significantly decreased cadmium concentration in their liver and blood. 478 It has been shown that hepatoprotective effect of E. senticosus extract is triggered by upregulation of expression Nrf2 and activation of innate antioxidant enzymes that increase the ratio of reduced versus oxidized glutathione in liver homogenate and serum.…”

Section: Molecular Mechanisms Of Action-effects On Intracellular Simentioning

confidence: 99%

“…Cytoprotective, antioxidant, and antitoxic effects of various adaptogenic preparations have been shown in many isolated cells as experimental models and (in vitro and ex vivo) in animals 1–4,9,26,27,69,71,474 . Extensive research on E. senticosus reveals its antitoxic, neuroprotective, hepatoprotective, cardioprotective, antioxidant, immunomodulating, and antiviral activities along with stress‐protective, antifatigue, hypoglycaemic, antidepressant and antiproliferative effects 3,8,46,474–481 . As an example, E. senticosus inhibits the cadmium‐induced apoptosis and mitosis of hepatocytes in mice, and significantly decreased cadmium concentration in their liver and blood 478 .…”

Section: Core Rational Of the Adaptogenic Conceptmentioning

confidence: 99%

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Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Panossian¹,

Efferth

Shikov

et al. 2020

Medicinal Research Reviews

194

124

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Adaptogens comprise a category of herbal medicinal and nutritional products promoting adaptability, resilience, and survival of living organisms in stress. The aim of this review was to summarize the growing knowledge about common adaptogenic plants used in various traditional medical systems (TMS) and conventional medicine and to provide a modern rationale for their use in the treatment of stress‐induced and aging‐related disorders. Adaptogens have pharmacologically pleiotropic effects on the neuroendocrine‐immune system, which explain their traditional use for the treatment of a wide range of conditions. They exhibit a biphasic dose‐effect response: at low doses they function as mild stress‐mimetics, which activate the adaptive stress‐response signaling pathways to cope with severe stress. That is in line with their traditional use for preventing premature aging and to maintain good health and vitality. However, the potential of adaptogens remains poorly explored. Treatment of stress and aging‐related diseases require novel approaches. Some combinations of adaptogenic plants provide unique effects due to their synergistic interactions in organisms not obtainable by any ingredient independently. Further progress in this field needs to focus on discovering new combinations of adaptogens based on traditional medical concepts. Robust and rigorous approaches including network pharmacology and systems pharmacology could help in analyzing potential synergistic effects and, more broadly, future uses of adaptogens. In conclusion, the evolution of the adaptogenic concept has led back to basics of TMS and a new level of understanding of holistic approach. It provides a rationale for their use in stress‐induced and aging‐related diseases.

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Section: Molecular Mechanisms Of Action-effects On Intracellular Simentioning

confidence: 99%

Section: Core Rational Of the Adaptogenic Conceptmentioning

confidence: 99%

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Panossian¹,

Efferth

Shikov

et al. 2020

Medicinal Research Reviews

194

124

View full text Add to dashboard Cite

show abstract

Influence of anEleutherococcus extract on the induction of recessive lethal mutations by cyclophosphane and N-nitrosomorpholine onDrosophila

Cited by 1 publication

References 1 publication

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases

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