Influence of Altitudinal Variation on the Content of Phenolic Compounds in Wild Populations of Calluna vulgaris, Sambucus nigra, and Vaccinium myrtillus

Rieger, G.; Müller, Maria; Guttenberger, Helmut; Bučar, Franz

doi:10.1021/jf801104e

Cited by 130 publications

(120 citation statements)

References 31 publications

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“…S. nigra consisted mainly of caffeic acid (913.19 µg/g), with lesser amounts of vanilic acid (299.38 µg/g), gallic acid (176.61 µg/g), and cinnamic acid (7.98 µg/g). Curiously, these results contrast to that of Rieger et al [31]. In their work, the caffeic acid was not detected in S. nigra; instead, they found rutin in high amounts, which we did not detect.…”

Section: Resultscontrasting

confidence: 99%

Edible flowers — antioxidant activity and impact on cell viability

Kuceková¹,

Mlček

Humpolíček³

et al. 2013

Open Life Sciences

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The phenolic compound composition, antioxidant activity and impact on cell viability of edible flower extracts of Allium schoenoprasum; Bellis perennis; Cichorium intybus; Rumex acetosa; Salvia pratensis; Sambucus nigra; Taraxacum officinale; Tragopogon pratensis; Trifolium repens and Viola arvensis was examined for the first time. Total phenolic content of the flowers of these plants fell between 11.72 and 42.74 mg of tannin equivalents/kg of dry matter. Antioxidant activity ranged from 35.56 to 71.62 g of ascorbic acid equivalents/kg of dry matter. Using the Human Hepatocellular Carcinoma cell-line (HepG2) and the Human Immortalized Non-tumorigenic Keratinocyte cell line (HaCaT), we assessed cell viability following a 3 day incubation period in media containing 25, 50, 75 and 100 μg/ml of total phenolic compounds using a colorimetric MTT assay. These three properties could make the herbs useful in treatment of various diseases like cancer. The tested extracts had significant effects on cell viability, but the effects were dependent not only on the phenolic compound concentration and the edible flowers species, but also on the phenolic compound and antioxidant profiles. In addition, responses differed between cell lines.

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Section: Resultscontrasting

confidence: 99%

Edible flowers — antioxidant activity and impact on cell viability

Kuceková¹,

Mlček

Humpolíček³

et al. 2013

Open Life Sciences

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“…Several experimental data support that enhanced solar, UV-B radiation is correlated to accumulation of highly antioxidative flavonoids (Jaakola et al, 2004;Markham et al, 1998;Spitaler et al, 2006). Previously, we showed that flavonols revealed significant differences in samples of Calluna vulgaris L. (Ericaceae) collected at different altitudes with increased levels of quercetin glycosides at higher altitudes whereas no significant correlation could be found for caffeoyl quinic acids and the dihydroflavonol glycoside callunin ( However, in the current study, we could not confirm the assumption that only the content of flavonol 3-Oglycosides with adjacent hydroxyl groups in ring B rise with increasing altitude (Ganzera et al, 2008b;Rieger et al, 2008) as also for compounds 11 and 13 a similar trend as for compound 12 was observed. Ganzera et al (2008a) showed that external factors like altitude and temperature had an effect on the secondary metabolites in Arnica montana L. (Asteraceae).…”

Section: Total Content Of Flavonoids and Phenolicscontrasting

confidence: 90%

Content of phenolic compounds in wild populations ofEpilobium angustifoliumgrowing at different altitudes

Monschein

Jaindl

Buzimkić

et al. 2015

Pharmaceutical Biology

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Context: Flavonoids are regarded as essential ingredients for the anti-inflammatory activity of Epilobium angustifolium L. (Onagraceae). The metabolic profiles of medicinal plants vary aside from genetic determination due to the influence by external factors. Objectives: This study evaluates the influence of altitudinal variation on the content of flavonoids in E. angustifolium in two consecutive growing periods. Materials and methods: Aerial and herbaceous plant materials were collected at three different altitudes (800, 1000, and 1500 m) during two collection periods. Plant samples (11-13 samples per altitude and year) were extracted with methanol using accelerated solvent extraction (ASE). Identification and quantification of the constituents were achieved by chromatographic means of HPLC-PDA and LC-PDA-MS analyses. Results: Rising concentrations of flavonol 3-O-glycosides could be detected with increasing altitude. The content of the major compound, quercetin 3-O-glucuronide, ranged from 4.4 ± 2.05 (800 m) to 4.9 ± 1.03 (1000 m) and up to 6.6 ± 1.14 mg/g (1500 m). The total amount of flavonol 3-O-glycosides in 73 analyzed samples ranged from 10.7 ± 1.37 up to 17.3 ± 1.99 mg/g. Discussion: Quercetin-3-O-glucuronide can be considered as a potential marker for the increased production of flavonols in herbal parts of E. angustifolium at higher altitudinal levels. Conclusion: The study confirms that environmental factors at higher altitude result in elevated levels of flavonols in aerial plant tissues of E. angustifolium. Specific factors for influencing the flavonoid content have to be clarified in further studies.

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“…nigra flowers there are a few publications on their phenolic composition but from other countries, such as France (Froehlicher et al, 2009) for C. monogyna, Austria (Rieger et al, 2008), Denmark (Christensen et al, 2008;Kaack and Christensen, 2010) and Poland For S. nigra, all the previous studies reported the presence of quercetin-3-O-glucoside (isoquercitrin) and quercetin-3-O-rutinoside (rutin), as well as different caffeoylquinic acids, as also observed in the present study (Christensen et al, 2008;Rieger et al 2008). …”

Section: Discussionmentioning

confidence: 99%

“…C. monogyna (Froehlicher et al, 2009) andS. nigra (Dawidowicz et al, 2003;Rieger et al, 2008;Christensen et al, 2008;Kaack and Christensen, 2010) flowers were studied, but with plant material from other European countries, i.e not growing under…”

Section: Introductionmentioning

confidence: 99%

Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal

Barros

Dueñas

Carvalho

et al. 2012

Food and Chemical Toxicology

125

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Crataegus monogyna, Cytisus multiflorus, Malva sylvestris and Sambucus nigra have been used as important medicinal plants in the Iberian Peninsula since a long time ago, and are claimed to have various health benefits. This study aimed to determine the phenolic profile and composition of wild medicinal flowers of those species. The analysis was performed by HPLC-DAD-ESI/MS. Flavonoids, and particularly flavonols and flavones, were the main groups in almost all the studied samples. C. multiflorus sample gave the highest levels of total flavonoids (54.5 mg/g dw), being a chrysin derivative the most abundant flavone found (22.3 mg/g dw). C. monogyna revealed the highest concentration in phenolic acids (5.5 mg/g dw) that were not found in C. multiflorus sample; 5-O-caffeoylquinic acid was the most abundant phenolic acid found in the first species, being a procyanidin trimer also found (1.4 mg/g dw). Kaempferol-3-O-rutinoside (0.84 mg/g dw) and quercetin-3-O-rutinoside (14.9 mg/g dw) were the main flavonols present in M. sylvestris and S. nigra, respectively. Due to the well established antioxidant activity of phenolic compounds, the studied wild medicinal flowers could be selected for processing extracts with health-promoting properties or to be incorporate into functional beverages or products with bioactive properties related to oxidative stress.

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Influence of Altitudinal Variation on the Content of Phenolic Compounds in Wild Populations of Calluna vulgaris, Sambucus nigra, and Vaccinium myrtillus

Cited by 130 publications

References 31 publications

Edible flowers — antioxidant activity and impact on cell viability

Edible flowers — antioxidant activity and impact on cell viability

Content of phenolic compounds in wild populations ofEpilobium angustifoliumgrowing at different altitudes

Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal

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