Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury

Shanmugarajan, T. S.; Sivaraman, D.; Somasundaram, I.; Arunsundar, M.; Krishnakumar, E.; Balaji, R.; Ravichandiran, V.

doi:10.1177/0748233708101215

Cited by 17 publications

(11 citation statements)

References 45 publications

(44 reference statements)

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“…The hepatotoxic effect of D-galactosamine was known to be mediated by an insufficiency of UDP-glucose and UDP-galactose and the loss of intracellular calcium homeostasis, leading to cell death (29). The activity of anti-oxidant enzymes were decreased after D-galactosamine treatment and the treatment of herbal extracts with anti-oxidant activities reversed anti-oxidant status and hepatic damage induced by D-galactosamine (30-32). In this report, we also demonstrated that ABG, which was known to have strong antioxidant effects, protected rats from CCl 4 - and D-galactosamine-induced hepatic injury.…”

Section: Discussionsupporting

confidence: 65%

Hepatoprotective Effect of Aged Black Garlic Extract in Rodents

Shin¹,

Lee²,

Oh³

et al. 2014

Toxicological Research

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In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.

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Section: Discussionsupporting

confidence: 65%

Hepatoprotective Effect of Aged Black Garlic Extract in Rodents

Shin¹,

Lee²,

Oh³

et al. 2014

Toxicological Research

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“…Significant increase in ALT and AST levels of sera of CPA treated rats was recorded in the present study. The same results were also observed after CPA treatment in albino rats [30]. Sondhi and Gupta [31] reported that treatment of white Zealand rabbits with CPA for five days revealed a significant increase in serum ALT and AST levels.…”

Section: Discussionsupporting

confidence: 70%

Ameliorative Effect of Fennel Oil on Cyclophosphamide Induced Hepatotoxicity in Albino Rats

Sakr¹,

Shalaby²,

Beder³

2017

BJPR

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Cyclophosphamide (CPA) is an alkylating agent widely used as an anticancer and immunosuppressive drug. Fennel (Foeniculum vulgare Mill) essential oil is a traditional medicine used against many diseases. The present work studied the effect of fennel oil against liver damage induced by the anticancer drug, cyclophosphamide (CPA) in albino rats. Animals were divided into 4 groups: group1: control, group2: orally given fennel oil (1 ml/kg body weight once a week for six weeks), group3: treated with CPA (15 mg/kg body weight once a week for six weeks) and group4: treated with CPA and fennel oil. The liver removed for histological and immunohistochemical preparation. Blood was collected and sera were prepared for biochemical analysis. The results revealed that CPA caused histological alterations in the liver including degeneration of hepatic cells, cytoplasmic vacuolation, fatty infiltration and congestion of blood vessels. Immunohistochemical observations revealed that both cell proliferation marker Ki67 and apoptotic marker caspase-3 were increased. Biochemical results revealed increase in the liver enzymes Original Research Article

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“…They suggested that α -lipoic acid protects kidney tissues by inhibiting neutrophil infiltration, balancing the oxidant-anti-oxidant status, and regulating the generation of inflammatory mediators. Shanmugarajan et al [51] evaluated the effect of α -lipoic acid supplementation on acute D-galactosamine-induced oxidative liver injury. Hepatotoxicity induced by D-galactosamine was evident from increase in lipid peroxidation and serum marker enzymes (GOT, GPT, ALP, and LDH).…”

Section: Discussionmentioning

confidence: 99%

Physiological and Histopathological Investigations on the Effects of-Lipoic Acid in Rats Exposed to Malathion

Al-Attar¹

2010

Journal of Biomedicine and Biotechnology

40
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29
0

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The present study was designed to evaluate the influence of α-lipoic acid treatment in rats exposed to malathion. Forty adult male rats were used in this study and distributed into four groups. Animals of group 1 were untreated and served as control. Rats of group 2 were orally given malathion at a dose level of 100 mg/kg body weight (BW) for a period of one month. Experimental animals of group 3 were orally given α-lipoic acid at a dose level of 20 mg/kg BW and after 3 hours exposed to malathion at the same dose given to group 2. Rats of group 4 were supplemented with α-lipoic acid at the same dose given to group 3. The activities of serum glutamic oxaloacetic acid transaminase (GOT), glutamic pyruvic acid transaminase (GPT), alkaline phosphatase (ALP), and acid phosphatase (ACP), and the values of creatinine, urea, and uric acid were statistically increased, while the values of total protein and total albumin were significantly decreased in rats exposed to malathion. Moreover, administration of malathion for one month resulted in damage of liver and kidney structures. Administration of α-lipoic acid before malathion exposure to rat can prevent severe alterations of hematobiochemical parameters and disruptions of liver and kidney structures. In conclusion, this study obviously demonstrated that pretreatment with α-lipoic acid significantly attenuated the physiological and histopathological alterations induced by malathion. Also, the present study identifies new areas of research for development of better therapeutic agents for liver, kidney, and other organs' dysfunctions and diseases.

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Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury

Cited by 17 publications

References 45 publications

Hepatoprotective Effect of Aged Black Garlic Extract in Rodents

Hepatoprotective Effect of Aged Black Garlic Extract in Rodents

Ameliorative Effect of Fennel Oil on Cyclophosphamide Induced Hepatotoxicity in Albino Rats

Physiological and Histopathological Investigations on the Effects of-Lipoic Acid in Rats Exposed to Malathion

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