Influence of Aloe Vera Gel on Dermal Wound Healing Process in Rat

Abstract

In this topical study the influence of Aloe Vera, on the wound healing process was investigated in 63 male rats with microscopic and cell count methods. On the day of surgery a round wound, of diameter 20 mm, was created on the back of rats necks under sterile conditions. The surgery day was determined as day zero (0). Then the rats were divided randomly into control and experimental groups 1 and 2. Animals in each group were sub-divided to three smaller groups, investigated every 4, 7, and 14 days. From day 0, wound surfaces were covered with gel once daily in experimental group 1 and twice daily, for 12 h interval, in experimental group 2. Each rat received 30 g of the gel. The wound surface and healing were assessed on days 4, 7, and 14, and then a sample from the wound was prepared and investigated microscopically. The results show that the number of neutrophil, macrophage, and fibroblast cells and the wound thickness in the control group were statistically different from the experimental groups. It was found that the wound diameter thickness in the experimental group was greatly lower due to twice administration of gel and the power of wound healing was more than other groups.

Structural and biochemical alterations during the healing process of tendons treated with Aloe vera

“…vera, known as "the healing plant" (Choi et al, 2001), is effective during healing processes in various tissues. Its effect is described in the literature for fibroblast proliferation, angiogenesis, production of different growth factors, synthesis of ECM components, such as hyaluronic acid, dermatan sulfate and collagen, and increased amount of crosslinks between the collagen molecules, in skin, bone fractures and gastric lesion (Chithra et al, 1998a,b,c;Somboonwong et al, 2000;Rodríguez et al, 2002;Eamlamnam et al, 2006;Prabjone et al, 2006;Habeeb et al, 2007;Takahashi et al, 2009;Takzare et al, 2009;Atiba et al, 2011;Tarameshloo et al, 2012). According to the results of Maia Filho et al (2010), A. vera phonophoresis was effective for the treatment of tendinitis, with reduction of edema and number of inflammatory cells, as well as promoting the recovery of the tensile strength of tendon.…”

Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model

“…Among all plant-derived functional foods, aloe products ranked first in health food sales of 2005 in Korea (Park et al 2005). Aloe is widely used in the food product and pharmaceutical industries due to its biological functions of anti-inflammatory activity (Speranza et al 2005), acceleration of wound healing (Takzare et al 2009), and protective effect against liver injury (Arosio et al 2000), although it is not well understood which activity is related to which component.…”

Alternative Medicines as Emerging Therapies for Inflammatory Bowel Diseases

“…Aloe is widely used in food products and ranked first in health food sales in 2005 in Korea for its biological function of anti-inflammatory activity [157] and acceleration in wound healing [158]. In a recent study, it was clearly shown that aloe components ameliorate inflammatory responses in a DSS-induced ulcerative colitis rat model [159].…”