Influence of allergen avoidance at high altitude on serum markers of eosinophil activation in children with allergic asthma

Boner, Attilio; Peroni, Diego; Piacentini, Giorgio; Venge, Per

doi:10.1111/j.1365-2222.1993.tb00294.x

Cited by 89 publications

(54 citation statements)

References 23 publications

(16 reference statements)

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“…It has been shown that children with dust mite allergy who have symptoms at sea level where dust mite exposure is high may clinically improve by moving to higher altitudes where dust mites are not as prominent [16]. Thus, when it is practical, avoiding allergen exposure for sensitive individuals is a useful tool in the management of the patient.…”

Section: O P Y R Ig H T G E N E R a L P R A C T Ic E A Ir W A Y S Gmentioning

confidence: 99%

In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice

Ahlstedt

Murray

2006

Primary Care Respiratory Journal

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SummaryThe basis of any diagnosis of allergy requires a good history and examination, which should then provide a certain degree of confidence as to whether or not allergy is present. However, the diagnosis cannot be confirmed on the basis of symptoms alone, because both allergic and non-allergic conditions can present with similar symptoms. Based on prevalence figures, about half of the patients presenting with allergic symptoms in primary care may be non-allergic. Therefore, allergy testing in the form of specific IgE (sIgE) measurement and/or skin prick testing is an invaluable aid in demonstrating both the presence and severity of such an allergy. The usefulness of such tests extends beyond just the positive or negative result. Often, more information can be gleaned by using the test results in a form of a continuous variable in order to determine the likelihood that allergy can be attributed as an explanation for patients' symptoms and disease. In this review, we describe the rationale for utilising specific IgE antibody tests in diagnosing allergy. Furthermore, to optimize the information gained from allergy testing, we describe how to employ one particular well-validated IgE testing system for determining the likelihood that an individual patient's disease can be attributed to allergy.

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Section: O P Y R Ig H T G E N E R a L P R A C T Ic E A Ir W A Y S Gmentioning

confidence: 99%

In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice

Ahlstedt

Murray

2006

Primary Care Respiratory Journal

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“…Besides standard treatment with inhaled and systemic glucocorticoids (GC) and b 2 -agonists, which aim on the reduction of local and systemic inflammation and bronchodilatation, high-altitude climate therapy is one major further treatment option for asthmatic patients [10][11][12][13][14]. Main factors that are suggested to influence asthma in high-altitude climate therapy are allergen avoidance, increased cortisol and catecholamine level, the dry air and high UV light exposure [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

High‐Altitude Climate Therapy Reduces Local Airway Inflammation and Modulates Lymphocyte Activation

Karagiannidis¹,

Hense

Rueckert³

et al. 2006

Scand J Immunol

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High-altitude climate therapy is a well-established therapeutic option, which improves clinical symptoms in asthma. However, little is known about the underlying immunological mechanisms. The study investigates the influence of high-altitude climate therapy on airway inflammation and cellular components of specific and unspecific immune response. Exhaled NO significantly decreased within 3 weeks of therapy in patients with allergic and intrinsic, moderate and severe asthma. Interleukin-10 (IL-10)-secreting peripheral blood mononuclear cells (PBMC) increased within 3 weeks of therapy in six of 11 patients, whereas transforming growth factor-b 1 -secreting PBMC remained stable. Furthermore, monocyte activation, assessed by CD80 expression significantly decreased during therapy. The frequency of CRTH2-expressing T cells decreased, while regulatory T cells (T reg ) remained stable. FOXP3 and GATA-3 mRNA expression in CD4 þ T cells did not change, while interferon-g and IL-13 mRNA expression decreased in eight of 10 patients. The current data demonstrate that high-altitude climate therapy reduces local airway inflammation. Furthermore, monocytes switch towards a tolerogenic phenotype under high-altitude climate therapy. The T reg /Th2 ratio increases; however, because of the absence of antigens/allergens, no de novo differentiation of Th2 nor T reg cells is observed. The high-altitude climate therapy therefore may form the immunological basis for the endogenous control of allergen-driven diseases.

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“…25 Other similar studies assessed changes of environment in which patients were moved to high altitude places where mite levels were low; in these cases, sensitized patients also improved. [26][27][28] A recent prospective study analyzed environment care measures for children at risk since birth, and demonstrated that there was no difference in sensitization to air allergens between the cared group and controls (in which no environmental measures were undertaken); there was, however, a difference in lung function between groups at age 3 years. 38 Studies that aimed to decrease allergen exposure in households reached conflicting results.…”

Section: Discussionmentioning

confidence: 99%

“…Various published papers had shown that there are variable responses to allergen control measures; the study design and the response assessments, however, varied among these papers, which has generated controversies among physicians. [17][18][19][20][21][22][23][24][25][26][27][28] The purpose of this paper was to discuss the difficulty of controlling allergen exposure and to review various studies in different environments within which individuals spend their days.…”

Section: Introductionmentioning

confidence: 99%

Diversidade da exposição alergênica: implicações na obtenção da eficácia do controle ambiental

Segundo

Sopelete

Terra³

et al. 2009

Rev. Bras. Otorrinolaringol.

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The prevalence of allergic diseases such as asthma, rhinitis, allergic conjunctivitis and atopic dermatitis has increased in the last decades. The relationship between allergen exposure, atopic sensitization and development of allergic diseases is widely described in the literature. Aim: To evaluate measures for reducing allergen exposure as part of the treatment of allergic diseases. Methods: An analysis was made of previous studies on allergen exposure done with a similar methodology in the central region of Brazil; the study included homes, hotels, cinemas, cars, taxis, buses and scholar transportation. Results: High levels of Der p 1 and Der f 1 mite allergens were found in a large proportion of the sample in most of the environments included in those studies; there were higher levels of pet allergens in cars and school transportation vehicles. Conclusion: The diversity of allergen exposure demonstrates the need for education about allergic diseases for patients and their families, as well as measures of reducing allergens in homes. This should be part of a global strategy of the management of allergic diseases, given that individuals live in society, not only in their houses.

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Influence of allergen avoidance at high altitude on serum markers of eosinophil activation in children with allergic asthma

Cited by 89 publications

References 23 publications

In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice

In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice

High‐Altitude Climate Therapy Reduces Local Airway Inflammation and Modulates Lymphocyte Activation

Diversidade da exposição alergênica: implicações na obtenção da eficácia do controle ambiental

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