Influence of aging on the sleep rebound induced by immobilization stress in the rat

Descamps, Amandine; Cespuglio, Raymond

doi:10.1016/j.brainres.2010.03.087

Cited by 17 publications

(11 citation statements)

References 43 publications

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“…It is well established that acute stress of various natures, as for instance, immobilization or predation, induces an adaptive effect of sleep rebound, consisting in an increase of the REM stage of sleep and to a lesser extent SWS, this is regarded as one of the important anti-stress mechanisms (Cespuglio et al, 1999; Marinesco et al, 1999; Koehl et al, 2002; Tang et al, 2007; Tiba et al, 2008; Couch et al, 2015). It was shown that stress-induced sleep rebound is decreased during aging (Clement et al, 2003; Descamps and Cespuglio, 2010), development of anhedonia during stress (Couch et al, 2015) and various neurochemical abnormalities associated with neuropsychiatric conditions (Bonnet et al, 2000; Meerlo et al, 2001; Boutrel et al, 2002; Vazquez-Palacios et al, 2004; Albu et al, 2014). While the exact functions of each of the stages of sleep are, as yet unclear, it is claimed that normal REM sleep is a crucial factor of memory consolidation (Rolls et al, 2013; Barnes and Wilson, 2014).…”

Section: Discussionmentioning

confidence: 99%

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

Cline

Costa-Nunes

Cespuglio

et al. 2015

Front. Behav. Neurosci.

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Central insulin receptor-mediated signaling is attracting the growing attention of researchers because of rapidly accumulating evidence implicating it in the mechanisms of plasticity, stress response, and neuropsychiatric disorders including depression. Dicholine succinate (DS), a mitochondrial complex II substrate, was shown to enhance insulin-receptor mediated signaling in neurons and is regarded as a sensitizer of the neuronal insulin receptor. Compounds enhancing neuronal insulin receptor-mediated transmission exert an antidepressant-like effect in several pre-clinical paradigms of depression; similarly, such properties for DS were found with a stress-induced anhedonia model. Here, we additionally studied the effects of DS on several variables which were ameliorated by other insulin receptor sensitizers in mice. Pre-treatment with DS of chronically stressed C57BL6 mice rescued normal contextual fear conditioning, hippocampal gene expression of NMDA receptor subunit NR2A, the NR2A/NR2B ratio and increased REM sleep rebound after acute predation. In 18-month-old C57BL6 mice, a model of elderly depression, DS restored normal sucrose preference and activated the expression of neural plasticity factors in the hippocampus as shown by Illumina microarray. Finally, young naïve DS-treated C57BL6 mice had reduced depressive- and anxiety-like behaviors and, similarly to imipramine-treated mice, preserved hippocampal levels of the phosphorylated (inactive) form of GSK3 beta that was lowered by forced swimming in pharmacologically naïve animals. Thus, DS can ameliorate behavioral and molecular outcomes under a variety of stress- and depression-related conditions. This further highlights neuronal insulin signaling as a new factor of pathogenesis and a potential pharmacotherapy of affective pathologies.

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Section: Discussionmentioning

confidence: 99%

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

Cline

Costa-Nunes

Cespuglio

et al. 2015

Front. Behav. Neurosci.

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“… Descamps and Cespuglio [479] showed that immobilization stress led to greatly increased plasma corticosterone levels in both young (3-mo) and old (24-mo) rats, although aging had no effect on such responses.  Garrido et al, [480] provided evidence that the basal levels of total plasma corticosterone measured in blood samples were not different between young (6-mo) and aged (27-mo) rats.…”

Section: Wistar Ratsmentioning

confidence: 99%

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Zaidi¹

2013

TOLSJ

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Steroid hormones are lipophilic, low-molecular weight organic compounds all of which are derived from cholesterol. They are primarily synthesized by steroidogenic glands such as gonads (ovary and testis), the adrenal gland and, during pregnancy, by the placental trophoblasts. Limited steroid synthesis also takes place in the brain. Steroid hormones are crucial for the proper functioning of the body. They mediate a wide variety of vital physiological functions, ranging from maintaining normal reproductive function and secondary sexual characteristics, to regulating virtually every metabolic process in the body. Like many age-related endocrine disorders, aging also progressively impacts the tissue-specific synthesis and secretion of steroid hormones. The goal of this review is to summarize the effects of aging on steroid hormone synthesis and secretion by the adrenal gland and gonads of both human and experimental animal models, to describe the potential involvement of excessive oxidative stress in mediating age-related alterations in steroidogenesis, and to discuss the possible underlying mechanisms involved.

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“…D etrimental changes in sleep duration and quality are more common with increasing age. 1,2 These alterations include a phase advance in circadian rhythms, thought to be the result of deterioration in the suprachiasmatic nuclei region of the brain. 1 Older adults also report an increased occurrence of sleep disorders associated with disrupted and fragmented sleep patterns.…”

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confidence: 99%

“…Disruption to SWS and REM sleep can lead to increased daytime sleepiness and a decreased ability to handle stress. 2 Age-related changes in sleep may contribute to cognitive decline among older individuals, yet this issue has not been extensively studied. Both short and long sleep duration have been linked to reduced cognitive performance.…”

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confidence: 99%

Associations between Sleep Duration, Sleep Quality, and Cognitive Test Performance among Older Adults from Six Middle Income Countries: Results from the Study on Global Ageing and Adult Health (SAGE)

Gildner

Liebert

Kowal

et al. 2014

Journal of Clinical Sleep Medicine

162

143

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Background: Alterations in sleep architecture are common among older adults. Previous studies have documented associations between sleep duration, sleep quality, and cognitive performance in older individuals, yet few studies have examined these trends using population-based samples from non-Western societies. The present cross-sectional study uses nationally representative datasets from six countries to test several hypotheses related to sleep patterns and cognitive function. Methods: Data were drawn from the fi rst wave of the World Health Organization's study on global ageing and adult health (SAGE), a longitudinal study using samples of older adults (≥ 50 years old) in 6 middle-income countries (China, Ghana, India, Russian Federation, South Africa, and Mexico). Selfreport data provided information on sleep quality and sleep duration over the previous 2 nights, and 5 cognitive tests (immediate and delayed verbal recall, forward and backward digit span, and verbal fl uency) were used to create a composite z-score of cognitive performance. Results: Individuals with intermediate sleep durations(> 6-9 h/night) exhibited signifi cantly higher cognitive scores than individuals with short sleep (0-6 h/night; p < 0.001) or long sleep duration (> 9 h/night; p < 0.001). Self-reported sleep quality was positively correlated with cognitive z-score (p < 0.05). Signifi cant sex differences were observed; men generally had higher sleep quality and cognitive scores, while women reported longer sleep durations. Discussion: This study documented positive correlations between cognitive scores and sleep quality, and between cognitive z-scores and intermediate sleep duration. These fi ndings are clinically important given the growing rates of dementia and aging populations globally. Keywords: cognitive function, aging, sleep duration, sleep quality, dementia Citation: Gildner TE, Liebert MA, Kowal P, Chatterji S, Snodgrass JJ. Associations between sleep duration, sleep quality, and cognitive test performance among older adults from six middle income countries: results from the study on global ageing and adult health (SAGE). J Clin Sleep Med 2014;10(6):613-621.http://dx.doi.org/10.5664/jcsm.3782 S C I E N T I F I C I N V E S T I G A T I O N SD etrimental changes in sleep duration and quality are more common with increasing age.1,2 These alterations include a phase advance in circadian rhythms, thought to be the result of deterioration in the suprachiasmatic nuclei region of the brain. Older adults also report an increased occurrence of sleep disorders associated with disrupted and fragmented sleep patterns. These conditions often reduce slow wave sleep (SWS) and REM sleep, the deepest and most restorative sleep stages. Disruption to SWS and REM sleep can lead to increased daytime sleepiness and a decreased ability to handle stress. Age-related changes in sleep may contribute to cognitive decline among older individuals, yet this issue has not been extensively studied. Both short and long sleep duration have been linked to reduced...

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Influence of aging on the sleep rebound induced by immobilization stress in the rat

Cited by 17 publications

References 43 publications

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression

Impact of Aging on Steroid Hormone Biosynthesis and Secretion

Associations between Sleep Duration, Sleep Quality, and Cognitive Test Performance among Older Adults from Six Middle Income Countries: Results from the Study on Global Ageing and Adult Health (SAGE)

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