Influence of ageing on antibody formation in vivo after immunisation with the primary T-cell dependent antigen Helix pomatia haemocyanin

Greef, Georgine E. de; Tol, Maarten J.D. van; Kallenberg, Cgm; Staalduinen, G.J. Van; Remarque, Ed; Tjandra, Y.I.; Hijmans, W.

doi:10.1016/0047-6374(92)90070-t

Cited by 15 publications

(6 citation statements)

References 15 publications

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“…However, the confounding effects of underlying disease make studies of age-related changes in the response to vaccination even more fraught with difficulty than for the cytokine secretion data (see section 4.4). Thus, although antibody responses following primary immunisations in the elderly are often reported to be decreased, immune responsiveness to the primary antigen Helix pomatia haemocyanin was retained in healthy elderly donors who fitted the SENIEUR protocol (441). By contrast, elderly subjects not fulfilling the SENIEUR criteria had a decreased immune responsiveness to this antigen.…”

Section: Vaccination (See Also Section 41)mentioning

confidence: 90%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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T cell immunosenescence 218effects of dysregulated immune responses in the elderly by supplementation or other approaches may result in an enhancement of their quality of life, and significant reductions in the cost of medical care in old age. FACTORS CONTRIBUTING TO IMMUNO-SENESCENCE HematopoiesisDysregulated hematopoiesis is seen in elderly individuals, raising the possibility that this could contribute to altered immune function in the aged. Hematopoiesis in man may be compromised because of a severely reduced capacity to produce colony stimulating factors (44) and increased production of pro-inflammatory factors such as IL 6 (45), because lower numbers of progenitor cells are present in the BM (46) and because of an age-related decline in proliferative potential of putative haematopoietic stem cells (HSC) (47). In mice, the repopulating potential of murine fetal liver-derived HSC is higher than that of adult BM-derived stem cells (48), suggesting possible aging of the HSC themselves. Normal cells with shorter telomeres possess less remaining replicative capacity than those with longer telomeres (see section 5.2). Accordingly, HSC from adult BM were found to have shorter telomeres than fetal liver-derived or umbilical cord-derived stem cells, consistent with aging of HSC (49). Telomere lengths decreased on culture despite low level expression of telomerase in these cells (50,51), although the rate of basepair loss per population doubling of cells in culture was lower during the first two weeks, when telomerase was upregulated, than in the next two, when it was downregulated (52). The telomerase expressed is therefore functionally active but may not be able to completely maintain telomere length in aging HSC cells. True embryonic stem cells (ESC), on the other hand, which may really be immortal, do retain high levels of telomerase activity (53). On the other hand, ESC from telomerase-knockout mice show gradual telomere shortening over many population doublings (PD) resulting in slowing and eventual cessation of growth (54). Certain animals which do not downregulate telomerase manifest a permanent growth phase and little or no senescence (55,56).

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Section: Vaccination (See Also Section 41)mentioning

confidence: 90%

T cells and aging (update February 1999)

Pawelec

1999

Front Biosci

113

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“…Because only 10% −12% of ambulatory, reasonably healthy elderly persons actually satisfy the strict SENIEUR admission criteria [24], these individuals do not accurately reflect the target high-risk population. The difficulty in identifying and enrolling elderly participants who do satisfy the SENIEUR Protocol may explain why only a few vaccination trials have been conducted under its strict guidelines, i.e., Haemocyanin [27], tetanus [28,29], and influenza [30,31,32] vaccines. The remainder of elderly clinical vaccine trials have opted to use looser eligibility criteria, making the specific effect of immunesenescence difficult to dissociate from potential confounding and biasing factors that are independent of age [23].…”

Section: Senieur Protocol For the Study Of Immune Responses In The Elmentioning

confidence: 99%

Vaccination in the elderly: an immunological perspective

Chen

Kozlovsky

Effros

et al. 2009

Trends in Immunology

224

187

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Successful vaccination of the elderly against important infectious pathogens which cause high morbidity and mortality represents a growing public health priority. Building upon the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently-licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly when compared to that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned in order to improve the effectiveness of next generation vaccines.

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“…Antibody responses following primary immunizations in the elderly are often reported to be decreased. However, immune responsiveness to the primary antigen Helix pomatia haemocyanin (HPH) was retained in healthy elderly SENIEURS (272). By contrast, elderly subjects not fulfilling the SENIEUR criteria had a decreased immune responsiveness to HPH.…”

Section: Clinical Relevance Of Immunosenescencementioning

confidence: 99%

T cells and aging

Pawelec

Remarque²,

Barnett³

et al. 1998

Front Biosci

130

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Deterioration of the immune system with aging ("immunosenescence") is believed to contribute to morbidity and mortality in man due to the greater incidence of infection, as well as possibly autoimmune phenomena and cancer in the aged. Dysregulation of T cell function is thought to play a critical part in these processes. Factors contributing to T cell immunosenescence may include a) stem cell defects, b) thymus involution, c) defects in antigen presenting cells (APC), d) aging of resting immune cells, e) disrupted activation pathways in immune cells, f) replicative senescence of clonally expanding cells. This review aims to consider the current state of knowledge on the scientific basis for and potential clinical relevance of those factors in immunosenescence.

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Influence of ageing on antibody formation in vivo after immunisation with the primary T-cell dependent antigen Helix pomatia haemocyanin

Cited by 15 publications

References 15 publications

T cells and aging (update February 1999)

T cells and aging (update February 1999)

Vaccination in the elderly: an immunological perspective

T cells and aging

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