Influence of age on the secretory rates of the human minor salivary glands and whole saliva

Shern, R.J.; Fox, Philip C.; Li, S.H.

doi:10.1016/0003-9969(93)90071-s

Cited by 77 publications

(39 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The enhanced protein concentration in periodontitis subjects cannot be attributed to a changed flow rate since any statistically significant difference in mean saliva flow rates was found [1,26]. Thus, the elevated protein levels are most likely due to enhanced synthesis and secretion by the individual salivary glands.…”

Section: Introductionmentioning

confidence: 61%

Experimental Periodontitis Induces a cAMP-dependent Increase in Amylase Activity in Parotid Glands from Male Rats

et al. 2009

View full text Add to dashboard Cite

It is known that subjects with periodontitis show enhanced amylase concentration in saliva. Our purpose was to analyze the release of amylase in parotid glands from rats with experimental periodontitis and controls. We present evidence that periodontitis induces an increase in resting amylase activity and release without changes in isoproterenol-induced amylase secretion. Changes in amylase were reverted by the inhibition of the adenylyl cyclase by SQ 22536, the cyclooxygenase type 1 by FR 122047 and by blocking the vasoactive intestinal peptide (VIP) receptor with VIP 6-28. Parotid glands from rats with periodontitis showed an increase in cAMP levels that was also reverted in the presence of SQ 22536, FR 122047 and VIP 6-28. We concluded that both PGE(2) and VIP are produced in parotid glands from rats with periodontitis and, by activating their own receptors in acinar cells, induce cAMP accumulation leading to an increase in amylase basal secretion.

show abstract

Section: Introductionmentioning

confidence: 61%

Experimental Periodontitis Induces a cAMP-dependent Increase in Amylase Activity in Parotid Glands from Male Rats

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The mean UWSFR ranged between 0.053 ml/min [3] to 0.61 ml/min [12]. Although comparisons are difficult to be made between studies due to considerable variations in study designs, the mean UWSFR for Jordanian subjects measured in this study is nearly comparable to that reported by studies conducted in Spain [6] and UK [11], higher than that reported in a Japanese study [3], but lower than that reported in a study conducted in USA [12] on healthy unmedicated adult patients.…”

Section: Discussionmentioning

confidence: 99%

The Unstimulated Salivary Flow Rate in a Jordanian Healthy Adult Population

2009

View full text Add to dashboard Cite

BackgroundEarly diagnosis of xerostomia is very important for oral health. The purpose of this study was to determine the unstimulated whole salivary flow rates (UWSFR) in a Jordanian Arab population aged 15 years and older. The effect of age, gender, height, weight, body mass index (BMI), smoking, alcohol consumption, and dental conditions, on UWSFR was also investigated.MethodsThe study was conducted on 244 subjects, 110 males and 134 females, with an average age of 33 ± 15.5 years. They were healthy, unmedicated, and with no history of dry mouth. Unstimulated whole saliva was collected during five minutes, and UWSFRs (ml/min) were determined. Data were analyzed by univariate analysis and multivariate regression analysis.ResultsThe mean UWSFR was 0.46 ± 0.25 ml/min (range: 0.10-1.6 ml/min). Eighteen patients (7.4%) had UWSFR between < 0.20 ml/min. In univariate analysis, UWSFR was significantly affected by age, BMI, number of missing and restored teeth, and DMFT score. Regression analysis revealed that only age and number of missing teeth were of significance in explaining the variability of the UWSFR.ConclusionsWe established basic standard values of UWSFR to be used in the evaluation of Jordanian patients with complaints of xerostomia and to be compared to data reported in other studies. UWSFR 0.1 ml/min could be considered the cut-off value that distinguishes normal from abnormal salivary function in this healthy unmedicated population.KeywordsWhole saliva flow rate; Unstimulated; Jordan

show abstract

Section: Salivary Flow Ratesmentioning

confidence: 83%

“…A decrease in salivary secretion rates with age has also been observed in stimulated parotid, 78 resting and stimulated submandibular 83 and resting 84,85 and stimulated 86,87 minor glands. On the other hand, an age-related decline was not observed in other studies of resting 87 and stimulated 88 whole salivary flow rate. Age effects were also not observed in other studies on resting 89 and stimulated 80,83,89,90 parotid salivary flow and in resting and stimulated submandibular saliva flow 90 and from minor salivary glands flow.…”

Section: Salivary Flow Ratesmentioning

confidence: 83%

Changes in Oral Microflora and Host Defences with Advanced Age

Percival

2009

Microbiology and Aging

View full text Add to dashboard Cite

Influence of age on the secretory rates of the human minor salivary glands and whole saliva

Cited by 77 publications

References 31 publications

Experimental Periodontitis Induces a cAMP-dependent Increase in Amylase Activity in Parotid Glands from Male Rats

Experimental Periodontitis Induces a cAMP-dependent Increase in Amylase Activity in Parotid Glands from Male Rats

The Unstimulated Salivary Flow Rate in a Jordanian Healthy Adult Population

Changes in Oral Microflora and Host Defences with Advanced Age

Contact Info

Product

Resources

About