Influence of age on sperm characteristics evaluated by light and electron microscopies

Collodel, Giulia; Ferretti, Fabio; Masini, Maurizio; Gualtieri, Giacomo; Moretti, Elena

doi:10.1038/s41598-021-84051-w

Cited by 23 publications

(12 citation statements)

References 67 publications

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“…In addition, we had poor sperm concentration, progressive motility, total sperm count, total progressive motile sperm count (TPMSC) and semen volume of samples from Nigeria which were older in age compared to South African samples which came from younger men. This is in concordance with reports that aging plays a major role in decreasing semen quality [42,43]. This is buttressed by our correlation analysis, which observed a signi cant inverse proportional relationship between age and all the sperm parameters analysed.…”

Section: Discussionsupporting

confidence: 93%

Male Infertility in Nigeria and South Africa: A Ten-Year Observational Study

Akang

Opuwari

Enyioma-Alozie

et al. 2023

Preprint

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Background: Male infertility is a disease of public health relevance contributing to 50% of infertility cases globally. However, there is dearth of information on the prevalence of male-factor infertility in Sub-Saharan countries. Therefore, in this study we aimed at identifying the prevalence, and trends of male factor infertility in Nigeria and South Africa over a period of ten years between 2010 and 2019. Methods:A retrospective study of semen analyses of 17,292 men attending fertility hospitals in Nigeria and South Africa in 2010, 2015 and 2019. Patients who had undergone vasectomy and those who had a pH less than 5 or greater than 10 were excluded from this study. The following variables were assessed: ejaculate volume, sperm concentration, progressive motility, total progressively motile sperm count (TPMSC), total sperm count, and normal sperm morphology Results: Between 2010 and 2019, significant trends of decreasing values were observed in normal sperm morphology (-50%), progressive motility (-89%), TPMSC (-91%) and the ejaculatory volume (-7%), indicating a progressive deterioration of the values in both countries. In Nigeria, there were significant decreases in progressive motility (-87%), TPMSC (-78%), and sperm morphology (-50%) between 2015-2019 (p<0.0001). Spearman`s rank correlation revealed significant negative associations between age and morphology (ρ = -0.24, p<0.0001), progressive motility (ρ= - 0.31. p<0.0001), and TPMSC (ρ = -0.32, p<0.0001). Patients in South Africa were younger than those from Nigeria, with also a significantly higher sperm morphology, sperm concentration, progressive motility, total sperm count and TPMSC. Conclusion: Our findings provide a quantitative evidence of an alarming decreasing trend in semen parameters in Nigeria and South Africa from 2010 to 2019. It also proves that astheno- and teratozoospermia are the leading causes of male infertility in these regions. In addition to this, it also shows empirically that semen parameters decrease with advancement in age. These findings are the first report on male-factor infertility prevalence in Sub-Saharan countries, necessitating a thorough investigation on the underlying factors promoting this worrisome decline.

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Section: Discussionsupporting

confidence: 93%

Male Infertility in Nigeria and South Africa: A Ten-Year Observational Study

Akang

Opuwari

Enyioma-Alozie

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, we recorded a reduction in the following semen parameters (sperm concentration, progressive motility, total sperm count, total progressive motile sperm count (TPMSC) and semen volume) with increase in age among Nigerian patients compared to South African samples which came from younger men. This is in concordance with reports that aging plays a major role in decreasing semen quality 31 , 32 . This is buttressed by our correlation analysis, which observed a significant inverse proportional relationship between age and all the semen parameters analysed.…”

Section: Discussionsupporting

confidence: 93%

Trends in semen parameters of infertile men in South Africa and Nigeria

Akang

Opuwari

Enyioma-Alozie

et al. 2023

Sci Rep

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There are conflicting reports on trends of semen parameters from different parts of the globe. However, in recent times there is dearth of information on the trend in Sub-Saharan countries. Therefore, in this study we aimed at determining the trends in semen parameters in Nigeria and South Africa between 2010 and 2019. A retrospective study of semen analyses of 17,292 men attending fertility hospitals in Nigeria and South Africa in 2010, 2015 and 2019. Patients who had undergone vasectomy and those who had a pH less than 5 or greater than 10 were excluded from this study. The following variables were assessed: ejaculate volume, sperm concentration, progressive motility, total progressively motile sperm count (TPMSC), total sperm count, and normal sperm morphology. Between 2010 and 2019, significant trends of decreasing values were observed in normal sperm morphology (− 50%), and the ejaculatory volume (− 7.4%), indicating a progressive deterioration of the values in both countries. In Nigeria, there were significant decreases in progressive motility (− 87%), TPMSC (− 78%), and sperm morphology (− 55%) between 2010 and 2019 (P < 0.001). Spearman`s rank correlation revealed significant negative associations between age and morphology (ρ = − 0.24, P < 0.001), progressive motility (ρ = − 0.31. P < 0.001), and TPMSC (ρ = − 0.32, P < 0.001). Patients in South Africa were younger than those from Nigeria, with also a significantly higher sperm morphology, sperm concentration, progressive motility, total sperm count and TPMSC. Our findings provide a quantitative evidence of an alarming decreasing trend in semen parameters in Nigeria and South Africa from 2010 to 2019. It also proves that astheno- and teratozoospermia are the leading causes of male infertility in these regions. In addition to this, it also shows empirically that semen parameters decrease with advancement in age. These findings are the first report of temporal trends in semen parameters in Sub-Saharan countries, necessitating a thorough investigation on the underlying factors promoting this worrisome decline.

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“…Significantly negative correlations were observed between the age of the men and the percentage of alive spermatozoa. Thus, advanced male age is associated with increased sperm apoptosis [ 54 , 55 ].…”

Section: Sperm Mitochondrial Dysfunction Male Infertility and Agingmentioning

confidence: 99%

Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions

Wang

Tehmina

et al. 2022

Pharmaceuticals

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Mitochondria are structurally and functionally unique organelles in male gametes. Apparently, as the only organelles remaining in mature sperm, mitochondria not only produce adeno-sine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) to support sperm mobility, but also play key roles in regulating reactive oxidation species (ROS) signaling, calcium homeostasis, steroid hormone biosynthesis, and apoptosis. Mitochondrial dysfunction is often associated with the aging process. Age-dependent alterations of the epididymis can cause alterations in sperm mitochondrial functioning. The resultant cellular defects in sperm have been implicated in male infertility. Among these, oxidative stress (OS) due to the overproduction of ROS in mitochondria may represent one of the major causes of these disorders. Excessive ROS can trigger DNA damage, disturb calcium homeostasis, impair OXPHOS, disrupt the integrity of the sperm lipid membrane, and induce apoptosis. Given these facts, scavenging ROS by antioxidants hold great potential in terms of finding promising therapeutic strategies to treat male infertility. Here, we summarize the progress made in understanding mitochondrial dysfunction, aging, and male infertility. The clinical potential of antioxidant interventions was also discussed.

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Influence of age on sperm characteristics evaluated by light and electron microscopies

Cited by 23 publications

References 67 publications

Male Infertility in Nigeria and South Africa: A Ten-Year Observational Study

Male Infertility in Nigeria and South Africa: A Ten-Year Observational Study

Trends in semen parameters of infertile men in South Africa and Nigeria

Age-Related Decline of Male Fertility: Mitochondrial Dysfunction and the Antioxidant Interventions

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