Influence of age on postischaemic reactive hyperaemia

Hagisawa, Satsue; Barbenel, J.C.; Kenedi, R M

doi:10.1088/0143-0815/12/3/003

Cited by 23 publications

(18 citation statements)

References 2 publications

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“…The observation that the peak and area under the curve of the reactive hyperaemia response were higher in the young compared to the older sedentary participants is consistent with previous findings (Hagisawa et al 1991;Boegli et al 2003). Comparison of the old fit and old sedentary data suggests that maintaining a high level of fitness prevents the age-related decline in microvascular reactivity.…”

Section: Discussionsupporting

confidence: 89%

“…Ageing is associated with attenuated vasodilator responses of the skin microcirculation to a variety of stimuli (Hagisawa et al 1991;Minson et al 2002;Holowatz et al 2003;James et al 2006), which is largely the result of endothelial dysfunction (Gates et al 2009). Endothelial dysfunction is considered an early and important promoter for atherosclerosis and thrombosis and thus contributes to the occurrence of cardiovascular events (Versari et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Effects of ageing and fitness on skin-microvessel vasodilator function in humans

2010

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The impact of cardiopulmonary fitness (VO(2max)) on the age-related decline in skin-microvessel vasodilator function has not been fully established and the inter-relationships among different measures of microvascular vasodilator function are unknown. We used laser Doppler flowmetry to assess relative changes in forearm skin blood flow to various stimuli in three groups of adults: young (n = 15; 27 +/- 2 years), older sedentary (n = 14; 65 +/- 6 years) and older fit (n = 15; 61 +/- 5 years). Local-heating induced and post-occlusive hyperaemia responses were higher in the young and older fit groups compared to the older sedentary group (P < 0.05) and were moderately correlated with VO(2max) in the pooled cohort of older adults (r = 0.49-0.58; P < 0.05). Peak hyperaemia responses to acetylcholine and sodium nitroprusside were higher in young compared to older sedentary adults (P < 0.05) and were not associated with VO(2max) in older adults (P > 0.05). Associations among different measures of microvascular vasodilator function were generally moderate at best. In summary, the local heating and reactive hyperaemia data indicate that the age-related decline in skin-microvessel vasodilator function can be ameliorated through regular aerobic exercise training. As this is not supported by the iontophoresis data, we recommend that, when assessing microvascular function, the use of a single physiological or pharmacological stimulation coupled to laser Doppler flowmetry should be avoided. Finally, the moderate correlations between outcomes probably reflect the distinct mediators that are responsible for the vasodilator response to each test.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of ageing and fitness on skin-microvessel vasodilator function in humans

2010

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“…59,60 The study of post-occlusive hyperaemia is, therefore, of importance as it is mediated by two major mediators: sensory nerves and endothelium-derived hyperpolarizing factors. [62][63][64][65] This attenuation is thought to be the result of endothelial dysfunction. 61 Thus, the stratum corneum is generally accepted to maintain its thickness during aging.…”

Section: Resultsmentioning

confidence: 99%

Laser speckle contrast imaging: age-related changes in microvascular blood flow and correlation with pulse-wave velocity in healthy subjects

2014

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In the cardiovascular system, the macrocirculation and microcirculation—two subsystems—can be affected by aging. Laser speckle contrast imaging (LSCI) is an emerging noninvasive optical technique that allows the monitoring of microvascular function and can help, using specific data processing, to understand the relationship between the subsystems. Using LSCI, the goals of this study are: (i) to assess the aging effect over microvascular parameters (perfusion and moving blood cells velocity, MBCV) and macrocirculation parameters (pulse-wave velocity, PWV) and (ii) to study the relationship between these parameters. In 16 healthy subjects (20 to 62 years old), perfusion and MBCV computed from LSCI are studied in three physiological states: rest, vascular occlusion, and post-occlusive reactive hyperaemia (PORH). MBCV is computed from a model of velocity distribution. During PORH, the experimental results show a relationship between perfusion and age (R(2) = 0.67) and between MBCV and age (R(2) = 0.72), as well as between PWV and age at rest (R(2) = 0.91). A relationship is also found between perfusion and MBCV for all physiological states (R(2) = 0.98). Relationships between microcirculation and macrocirculation (perfusion-PWV or MBCV-PWV) are found only during PORH with R(2) = 0.76 and R(2) = 0.77, respectively. This approach may prove useful for investigating dysregulation in blood flow.

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“…Increasing age and advanced CKD are both associated with an attenuated vasodilator response of the skin microcirculation [8, 9, 10, 11, 12]. However, whether aging impairs endothelium-dependent vasoreactivity in CKD patients even further is presently unknown.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to CKD, aging is also associated with an attenuated vasodilator response of the microcirculation to a variety of stimuli [8, 9, 10, 11, 12] which is largely the result of endothelial dysfunction. Accelerated vascular aging, associated with Klotho deficiency, is a characteristic of subjects with CKD [13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

Premature Aging of the Microcirculation in Patients with Advanced Chronic Kidney Disease

Thang¹,

Serné²,

Grooteman³

et al. 2012

Nephron Extra

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Background: Increasing age and advanced chronic kidney disease (CKD) are both associated with an attenuated vasodilator response of the skin microcirculation. In the present study, we investigated the effect of aging on microvascular reactivity in patients with advanced CKD. Methods: Acetylcholine (ACh)-mediated endothelium-dependent vasodilation and sodium nitroprusside (SNP)-mediated endothelium-independent vasodilation were assessed by iontophoresis combined with laser Doppler flowmetry. Microvascular function was compared between 52 patients with advanced CKD (stage 4–5: n = 16; end-stage renal disease: n = 36) and 33 healthy control subjects. As aging has an important effect on microvascular function, both control subjects and CKD patients were divided in subgroups younger and older than 45 years. Linear regression analysis was applied to assess potential associations between microvascular function and various demographic and clinical parameters. Results: There were three main findings. (1) In young patients with advanced CKD, both ACh- and SNP-mediated vasodilations were impaired if compared to young healthy controls (p = 0.04 and p = 0.056, respectively). (2) In young patients with advanced CKD, microvascular function was similar to old healthy controls and elderly patients with advanced CKD. (3) Whereas age was inversely associated with microvascular function in healthy controls (log ACh-mediated vasodilation R = –0.41; p = 0.02 and log SNP-mediated vasodilation R = –0.38; p = 0.03), no such relation was found in patients with advanced CKD. Conclusions: Our results are consistent with premature aging of the microvascular vasodilatory capacity in patients with advanced CKD.

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Influence of age on postischaemic reactive hyperaemia

Cited by 23 publications

References 2 publications

Effects of ageing and fitness on skin-microvessel vasodilator function in humans

Effects of ageing and fitness on skin-microvessel vasodilator function in humans

Laser speckle contrast imaging: age-related changes in microvascular blood flow and correlation with pulse-wave velocity in healthy subjects

Premature Aging of the Microcirculation in Patients with Advanced Chronic Kidney Disease

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