Influence of Age of Rabbits on the Toxicity of Ouabain*,†

Chen, K.K.; Robbins, Edward

doi:10.1002/jps.3030330207

Cited by 11 publications

(2 citation statements)

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“…Wollenberger et al (119), however, found no change in the sensitivity of guinea‐pig myocardium to ouabain during adult life up to 5–6 1/2 year group; the lethal dose decreased from birth to maturity (5 1/2–7 1/2 months). On the other hand, Chen and Robbins (3, 120) observed that rabbits 3–5 years of age were more susceptible to ouabain, administered intravenously, than were animals 3 to 24 months of age; animals aged 1 1/2 months were the most tolerant.…”

Section: Drugs That Act Primarily On the Cardiovascular Renal Or Blmentioning

confidence: 99%

Pharmacologic Aspects of Aging: A Survey of the Effect of Increasing Age on Drug Activity in Adults

Bender

1964

J American Geriatrics Society

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Section: Drugs That Act Primarily On the Cardiovascular Renal Or Blmentioning

confidence: 99%

Pharmacologic Aspects of Aging: A Survey of the Effect of Increasing Age on Drug Activity in Adults

Bender

1964

J American Geriatrics Society

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“…Whilst patient error (Harman, 1971), multiple diseases inviting polypharmacy (Davison, 1971), increased tissue sensitivity (Hall, Ettinger & Banting, 1936), and a lowering of the threshold to activate receptors (Chen & Brown Robbins, 1943) may account for some of these adverse drug reactions, they are more likely to be due to an increase in the concentration of circulating drug. Such an increase could result from decreased efficiency of drug metabolizing enzymes.…”

Section: Introductionmentioning

confidence: 99%

The effect of age on plasma levels of propranolol and practolol in man.

Castleden¹,

Kaye²,

Parsons³

1975

Brit J Clinical Pharma

137

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1Plasma levels of propranolol and practolol were measured in groups of elderly and young subjects, after the oral administration of propranolol (40 mg) and practolol (200 mg) on separate occasions. 2 At all sampling times the mean plasma propranolol level in the group of elderly subjects was substantially greater than the corresponding level in the group of young subjects, there being a significant difference between the two, and a fourfold difference in the mean peak levels. 3 After practolol, there was no significant difference between the mean plasma concentrations of the drug in the two groups for the first 2 hours. Subsequently, the mean plasma levels in the group of elderly subjects were somewhat higher than the corresponding levels in the young group, the differences between the two reaching significance. 4 It is suggested that there is a need to substantially reduce the dose of propranolol given to elderly patients. With practolol, however, no reduction is necessary providing renal function is normal for the patient's age.

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Chairman's Introduction

Williams

1962

Ciba Foundation Symposium ‐ Enzymes and Drug Action

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Influence of Age of Rabbits on the Toxicity of Ouabain*,†

Cited by 11 publications

References 0 publications

Pharmacologic Aspects of Aging: A Survey of the Effect of Increasing Age on Drug Activity in Adults

Pharmacologic Aspects of Aging: A Survey of the Effect of Increasing Age on Drug Activity in Adults

The effect of age on plasma levels of propranolol and practolol in man.

Chairman's Introduction

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